INT81486

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Context Info
Confidence 0.81
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 38
Disease Relevance 12.94
Pain Relevance 15.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP3) extracellular space (MMP3) extracellular region (MMP3)
proteinaceous extracellular matrix (MMP3) nucleus (MMP3) protein complex (MMP3)
Anatomy Link Frequency
fibroblasts 11
chondrocytes 2
temporomandibular joint 2
synovium 2
plasma 1
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 1389 100.00 Very High Very High Very High
Snapping jaw 8 99.64 Very High Very High Very High
cytokine 169 99.46 Very High Very High Very High
Inflammation 260 99.26 Very High Very High Very High
Osteoarthritis 655 98.04 Very High Very High Very High
pulpitis 12 97.88 Very High Very High Very High
Infliximab 198 95.48 Very High Very High Very High
Pain 305 94.64 High High
cva 1 89.28 High High
Inflammatory mediators 12 83.52 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 8 99.64 Very High Very High Very High
INFLAMMATION 291 99.26 Very High Very High Very High
Osteoarthritis 526 98.04 Very High Very High Very High
Pulpitis 12 97.88 Very High Very High Very High
Disease 137 96.32 Very High Very High Very High
Pain 381 94.64 High High
Stroke 6 93.36 High High
Injury 90 91.84 High High
Pressure And Volume Under Development 24 89.84 High High
Arthropathy 12 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The localization of matrix metalloproteinase-3 and tenascin in synovial membrane of the temporomandibular joint with internal derangement.
Localization (localization) of matrix metalloproteinase-3 in temporomandibular joint associated with snapping jaw and metalloproteinase
1) Confidence 0.81 Published 1999 Journal Oral Dis Section Title Doc Link 10218042 Disease Relevance 0.10 Pain Relevance 0.24
CONCLUSION: Comparative localization of MMP-3 and tenascin revealed intense staining for both in the synovial membrane presenting inflammation, proliferation and hypertrophy.
Localization (localization) of MMP-3
2) Confidence 0.81 Published 1999 Journal Oral Dis Section Body Doc Link 10218042 Disease Relevance 0.06 Pain Relevance 0
OBJECTIVES: The aim of this investigation was to study the immunohistochemical localization of MMP-3 and tenascin in the temporomandibular joint and to compare it with control specimens.
Localization (localization) of MMP-3 in temporomandibular joint associated with snapping jaw
3) Confidence 0.81 Published 1999 Journal Oral Dis Section Abstract Doc Link 10218042 Disease Relevance 0.17 Pain Relevance 0.21
Primers for the genes encoding a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS)-5 (aggrecanase-2), matrix metalloproteinase (MMP)-3 (stromelysin), osteocalcin, alkaline phosphatase and type I collagen ?
Localization (alkaline phosphatase) of stromelysin associated with metalloproteinase
4) Confidence 0.73 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860078 Disease Relevance 0.06 Pain Relevance 0.15
One interesting finding of this study is that preterm and term cervical fibroblasts show different secretion patterns of IL-8, MMP-1 and MMP-3, where IL-8 and MMP-1 are secreted at higher levels in preterm and MMP-3 in term cervical fibroblasts.
Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
5) Confidence 0.70 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.44
The clinical significance of different secretion patterns of IL-8, MMP-1 and MMP3 in preterm and term cervical fibroblasts still needs to be elucidated.
Localization (secretion) of MMP3 in fibroblasts associated with metalloproteinase
6) Confidence 0.70 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.61
It has been shown in vitro that stromelysin, or MMP-3,15 is able to cleave HbEGF at the juxtamembrane site, releasing the mature, soluble form of the growth factor to signal in a paracrine or juxtacrine fashion.
Localization (releasing) of stromelysin
7) Confidence 0.68 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501117 Disease Relevance 0.45 Pain Relevance 0.04
Immunohistochemically, MMP-1 and MMP-3 were localized in the infiltrating neutrophils, macrophages, and extracellular matrix of the acute pulpitis group.
Localization (localized) of MMP-3 in extracellular matrix associated with pulpitis and metalloproteinase
8) Confidence 0.67 Published 2002 Journal J Endod Section Abstract Doc Link 12043871 Disease Relevance 0.38 Pain Relevance 0.76
Aflapin inhibits secretion of MMP-3 in TNF?
Localization (secretion) of MMP-3
9) Confidence 0.65 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.73 Pain Relevance 0.55
g/ml) in inhibiting MMP-3 secretion from TNF?
Localization (secretion) of MMP-3
10) Confidence 0.65 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.85 Pain Relevance 0.44
-induced chondrocytes and dose-dependent inhibition of MMP-3 secretion in 5-Loxin and Aflapin treated cultures.
Localization (secretion) of MMP-3 in chondrocytes
11) Confidence 0.65 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.84 Pain Relevance 0.46
The results on the secretion of MMP-1 and MMP-3 from cervical fibroblasts contradict the findings by Li and Challis (2005).
Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
12) Confidence 0.65 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.38
Furthermore, preterm and term cervical fibroblasts showed different secretion patterns of IL-8, MMP-1 and MMP-3.
Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
13) Confidence 0.65 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.74
RPN 2610, RPN 2617, RPN 2613, RPN 2614, RPN 2611, RPN 2618, RPN 2612) for the determination of MMP1, MMP2, MMP3, MMP9, TIMP1, TIMP2, and MTC1 concentrations in the blood plasma of the patients and the control group.
Localization (concentrations) of MMP3 in plasma
14) Confidence 0.64 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.12 Pain Relevance 0.05
However, different secretion patterns of IL-8, MMP-1 and MMP-3 in preterm and term cervical fibroblasts indicate that they might have different phenotypes.
Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
15) Confidence 0.61 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0 Pain Relevance 0.25
Therefore, our present aim was to determine if CRH has an effect on the secretion of IL-8, MMP-1 and MMP-3 in both preterm and term cervical fibroblasts.
Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
16) Confidence 0.61 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.27 Pain Relevance 0.36
We have shown that CRH increased the secretion of IL-8 in both preterm and term cervical fibroblasts, but did not affect the secretion of MMP-1 and MMP-3.
Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
17) Confidence 0.61 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.08 Pain Relevance 0.42
However, preterm and term cervical fibroblasts might have different phenotypes based on different secretion patterns of IL-8, MMP-1 and MMP-3.



Localization (secretion) of MMP-3 in fibroblasts associated with metalloproteinase
18) Confidence 0.61 Published 2008 Journal Molecular Human Reproduction Section Abstract Doc Link PMC2639405 Disease Relevance 0.15 Pain Relevance 0.37
Under the influence of pro-inflammatory cytokines, increased production and secretion of collagenases such as MMP-3, MMP-13 is the crucial event for enhanced collagen degradation in OA 39.
Localization (secretion) of MMP-3 associated with inflammation, osteoarthritis and cytokine
19) Confidence 0.61 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.75 Pain Relevance 0.56
Effect on secretion of MMP3 in TNF?
Localization (secretion) of MMP3
20) Confidence 0.61 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2974165 Disease Relevance 0.09 Pain Relevance 0

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