INT81493

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Context Info
Confidence 0.65
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 13.63
Pain Relevance 6.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 2
cerebrospinal fluid 1
fibroblasts 1
eosinophils 1
blood 1
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 241 100.00 Very High Very High Very High
cytokine 109 100.00 Very High Very High Very High
chemokine 84 100.00 Very High Very High Very High
Multiple sclerosis 12 99.80 Very High Very High Very High
Neuritis 2 99.66 Very High Very High Very High
orphanin 7 99.56 Very High Very High Very High
dorsal root ganglion 4 99.12 Very High Very High Very High
ischemia 8 98.74 Very High Very High Very High
Cannabinoid receptor 7 96.32 Very High Very High Very High
dexamethasone 43 94.12 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 256 100.00 Very High Very High Very High
Demyelinating Disease 12 99.80 Very High Very High Very High
Primary Sclerosing Cholangitis 31 99.76 Very High Very High Very High
Optic Neuritis 2 99.66 Very High Very High Very High
Injury 13 99.46 Very High Very High Very High
Coronary Artery Disease 32 99.44 Very High Very High Very High
Ganglion Cysts 5 99.12 Very High Very High Very High
Hypoxia 1 98.92 Very High Very High Very High
Cv Unclassified Under Development 8 98.74 Very High Very High Very High
Occupational Lung Diseases 24 98.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhancement of IL-8 and MCP-1 gene transcription and protein production was shown to be pertussis toxin sensitive attesting that this phenomenon was a Gi protein-coupled receptor-mediated process as expected for cannabinoid receptors.
Transcription (transcription) of MCP-1 associated with bordatella infection and cannabinoid receptor
1) Confidence 0.65 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.10 Pain Relevance 0.66
Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both MCP-1 and mRNA for its receptor CCR2.
Transcription (expression) of MCP-1 in DRG associated with ganglion cysts, nociception, dorsal root ganglion and injury
2) Confidence 0.61 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775210 Disease Relevance 0.81 Pain Relevance 0.22
In line with the microarray data compared to their average expressions in PSC, VCAM1 and CCL2 mRNA expressions were 5.66-fold (p = 0.0016) and 2.28-fold (p = 0.0020) higher in HSC as determined by qRT-PCR, respectively (Figure 7A & Figure 8D).
Transcription (expressions) of CCL2 associated with cirrhosis and primary sclerosing cholangitis
3) Confidence 0.51 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2876060 Disease Relevance 1.29 Pain Relevance 0.05
At these concentrations, LY29, but not WM, significantly inhibited constitutive and IL-1beta-induced MCP-1 expression at both protein and mRNA levels.
Transcription (levels) of MCP-1
4) Confidence 0.47 Published 2004 Journal FEBS Lett. Section Abstract Doc Link 14960322 Disease Relevance 0 Pain Relevance 0.07
We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients.
Transcription (concentration) of CCL2 in cerebrospinal fluid associated with multiple sclerosis, optic neuritis and neuritis
5) Confidence 0.33 Published 2004 Journal Eur. J. Neurol. Section Abstract Doc Link 15257681 Disease Relevance 0.82 Pain Relevance 0.57
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CCL2 associated with coronary artery disease
6) Confidence 0.25 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.95 Pain Relevance 0.30
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CCL2 associated with coronary artery disease
7) Confidence 0.24 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.98 Pain Relevance 0.36
Patients with CAD showed higher constitutive expression of CCL2, CXCL8, CXCL9, CXCL10 and IFN-gamma mRNA and, after stimulation with oxLDL, higher expression of CCL2 and CXCL8 mRNA than the control group.
Transcription (expression) of CCL2 associated with coronary artery disease
8) Confidence 0.24 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.97 Pain Relevance 0.36
We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-gamma and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL).
Transcription (expression) of CCL2 in coronary artery associated with coronary artery disease
9) Confidence 0.24 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.68 Pain Relevance 0.26
In this study, we show that human cere-bromicrovascular endothelial cells (HCEC) subjected to a 4 h in vitro ischemia (hypoxia + glucose deprivation) followed by a 4-24 h recovery express elevated levels of ICAM-1, IL-8, and MCP-1 mRNAs (semi-quantitative RT-PCR) and secrete increased amounts of the immunoreactive chemokines IL-8 and MCP-1 (ELISA).
Transcription (express) of MCP-1 in HCEC associated with chemokine, hypoxia and ischemia
10) Confidence 0.19 Published 2000 Journal Acta Neurochir. Suppl. Section Abstract Doc Link 11450070 Disease Relevance 0.97 Pain Relevance 0.43
We studied the expression of CCR2 on leukocytes in blood and cerebrospinal fluid (CSF) from patients with monosymptomatic optic neuritis and MS, and the concentration of CCL2 in the CSF from these patients.
Transcription (concentration) of CCL2 in blood associated with multiple sclerosis, optic neuritis and neuritis
11) Confidence 0.11 Published 2004 Journal Eur. J. Neurol. Section Abstract Doc Link 15257681 Disease Relevance 0.82 Pain Relevance 0.57
When stimulated by TLR ligands, human melanocytes can: (1) release IL-6 and IL-8 cytokines, (2) enhance chemokine (CCL2, CCL3, and CCL5) mRNA production, (3) upregulate phosphorylated I?
Transcription (production) of CCL2 in melanocytes associated with chemokine and cytokine
12) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.59 Pain Relevance 0.17
In synoviocytes, BEB3-crosslinked hTWEAK increased the mRNA level of IL-8, MCP-1, RANTES, IP-10 and MIP-1?.
Transcription (level) of MCP-1
13) Confidence 0.08 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.23 Pain Relevance 0.13
In dermal fibroblasts, BEB3-crosslinked hTWEAK was shown to increase the mRNA level of three chemokines of the CXC or CC families, IL-8, MCP-1 and RANTES.
Transcription (level) of MCP-1 in fibroblasts associated with chemokine
14) Confidence 0.08 Published 2002 Journal Arthritis Res Section Body Doc Link PMC83846 Disease Relevance 0.21 Pain Relevance 0.13
It was demonstrated that urinary mRNA expression of MCP-1 and other chemokines correlated significantly with SLE disease activity scores and anti-dsDNA titers during the course of immunosuppressive treatment.
Transcription (expression) of MCP-1 associated with chemokine, disease and systemic lupus erythematosus
15) Confidence 0.08 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2857808 Disease Relevance 0.80 Pain Relevance 0.13
Furthermore, simultaneous in situ hybridization and immunocytochemistry has demonstrated 85% of the IL-5 mRNA-positive cells in the distal airways to be CD3+ T cells, similar to the proportion found in the large airways (81%).[12] In addition, we have recently shown increased eotaxin and monocyte chemotactic protein -4 mRNA expression in the distal airway epithelium of asthmatics compared to non-asthmatics and the number of chemokine positive cells in the distal airways of these patients to correlate with the number of MBP + eosinophils at this same site.[13]
Transcription (expression) of monocyte chemotactic protein in eosinophils associated with chemokine and occupational lung diseases
16) Confidence 0.07 Published 2007 Journal Annals of Thoracic Medicine Section Body Doc Link PMC2732069 Disease Relevance 0.55 Pain Relevance 0.08
Although the glucocorticoid action in inflammatory diseases is not fully understood, it is well documented that glucocorticoids inhibit the transcription of the majority of inflammatory cytokines and chemokines involved in the inflammatory process, including eotaxin, GM-CSF, IL-1ß, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, IL-11, MCP-1, MIP-1, MIP-3, MIP-4, MIP-1?
Transcription (transcription) of MCP-1 associated with chemokine, inflammation, disease and cytokine
17) Confidence 0.07 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790480 Disease Relevance 1.30 Pain Relevance 0.56
However, nociceptin does not appear to regulate the expression of these chemokines at the level of transcription, as CCL2/MCP-1 and CCL5/RANTES mRNA levels following nociceptin treatment of monocytes were essentially normal.
Transcription (levels) of CCL2/MCP-1 in monocytes associated with chemokine and orphanin
18) Confidence 0.06 Published 2008 Journal J Neuroimmune Pharmacol Section Abstract Doc Link 18247127 Disease Relevance 0.16 Pain Relevance 0.91
Recently, increased expression of eotaxin and monocyte chemotactic protein-4 mRNA has been reported in the epithelial cell layer (Fig. 5) and in the airway wall of small airways of asthmatic persons as compared with nonasthmatic control individuals [6].
Transcription (expression) of monocyte chemotactic protein in monocyte associated with asthma
19) Confidence 0.05 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.41 Pain Relevance 0.10
It is proposed that the major mechanism by these anti-inflammatory agents is a shared pathway dependent on the suppression of NF-kappaB activity, which may subsequently decrease transcription of growth factors, chemokines and proteases such as COX-2, VEGF, IL-8/CXCL8, MCP-1/CCL-2, MIP1alpha/CCL-3, tPA and uPA, which are shown to be elevated in ovarian carcinoma, and which play diverse roles such as inducing angiogenesis, invasion, autocrine growth loops and resistance to apoptosis.
Transcription (transcription) of CCL-2 associated with chemokine, inflammation, ovarian cancer and apoptosis
20) Confidence 0.03 Published 2004 Journal Neoplasma Section Abstract Doc Link 15254653 Disease Relevance 0.99 Pain Relevance 0.71

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