INT81494

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 11
Disease Relevance 1.54
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR2) signal transducer activity (CNR2)
Anatomy Link Frequency
monocyte 4
brain 2
RBL-2H3 2
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid receptor 66 100.00 Very High Very High Very High
chemokine 13 100.00 Very High Very High Very High
Cannabinoid 88 99.98 Very High Very High Very High
Inflammation 119 99.84 Very High Very High Very High
Endocannabinoid 136 97.48 Very High Very High Very High
corticosteroid 35 96.52 Very High Very High Very High
imagery 8 95.40 Very High Very High Very High
Analgesic 8 94.76 High High
antagonist 20 85.60 High High
analgesia 2 66.08 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 115 99.84 Very High Very High Very High
Bordatella Infection 5 87.52 High High
Colitis 50 80.48 Quite High
Inflammatory Bowel Disease 135 75.68 Quite High
Ganglion Cysts 35 70.32 Quite High
Hypothermia 1 67.12 Quite High
Frailty 90 50.00 Quite Low
Rheumatoid Arthritis 99 5.00 Very Low Very Low Very Low
Disease 48 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These upregulations initially observed in transfected HL60 cells overexpressing CB2 receptors, also occurred in normal non-transfected HL60 cells.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of CB2 associated with cannabinoid receptor
1) Confidence 0.62 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.09 Pain Relevance 0.65
In fact, PEA does not bind to CB1 and CB2 receptors transfected into host cells, but might be a ligand for a putative CBn receptor present in the RBL-2H3 cell line.
Positive_regulation (transfected) of Gene_expression (transfected) of CB2 in RBL-2H3
2) Confidence 0.49 Published 1999 Journal Curr. Med. Chem. Section Abstract Doc Link 10469890 Disease Relevance 0.10 Pain Relevance 0.36
Using the recently developed methodology of nucleic acid microarrays spotted with specific cDNAs probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand CP-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (IL-8) and the beta-chemokine monocyte chemotactic protein-1 (MCP-1), in the promyelocytic cell line HL60 transfected with peripheral cannabinoid receptors (CB2).
Positive_regulation (transfected) of Gene_expression (transfected) of CB2 in monocyte associated with chemokine, cannabinoid receptor and cannabinoid
3) Confidence 0.45 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.05 Pain Relevance 0.45
Using the recently developed methodology of nucleic acid microarrays spotted with specific cDNAs probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand CP-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (IL-8) and the beta-chemokine monocyte chemotactic protein-1 (MCP-1), in the promyelocytic cell line HL60 transfected with peripheral cannabinoid receptors (CB2).
Positive_regulation (upregulated) of Gene_expression (transfected) of CB2 in monocyte associated with chemokine, cannabinoid receptor and cannabinoid
4) Confidence 0.45 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.05 Pain Relevance 0.45
We detected an increase of CB2 expression in acute group comparing with the control one [61.09±2.54 vs 53.30±1.27 (×103); p<0.01].
Positive_regulation (increase) of Gene_expression (expression) of CB2
5) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.20 Pain Relevance 0.04
In contrast, increased CB2 expression was reversed in quiescent group [61.09±2.54 vs 55.15±1.69 (×103); p<0.01].
Positive_regulation (increased) of Gene_expression (expression) of CB2
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.21 Pain Relevance 0.04
Although cannabinoid CB2 receptor expression is increased in inflammatory disorders, the presence and function of the remaining proteins of the endocannabinoid system in the colonic tissue is not well characterized.


Positive_regulation (increased) of Gene_expression (expression) of CB2 associated with endocannabinoid, inflammation and cannabinoid
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731878 Disease Relevance 0.27 Pain Relevance 0.41
By contrast, CB2 and MAGL expression increased in 5-ASA-treated patients but not after the remaining treatments [57.20±1.87 vs 53.29±1.52 (×103) for CB2; 68.78±1.78 vs 60.03±0.72 (×103) for MAGL; p<0.05].
Neg (not) Positive_regulation (increased) of Gene_expression (expression) of CB2
8) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.27 Pain Relevance 0.14
These data may indicate an overexpression of CB2 receptor during the acute inflammation but, once controlled by the treatment, restored to basal levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CB2 associated with inflammation
9) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.23 Pain Relevance 0.05
Reverse transcription-polymerase chain reaction for CB1 and CB2 receptors
Positive_regulation (reaction) of Gene_expression (receptors) of CB2
10) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0 Pain Relevance 0.09
SR147778 is able to block the mitogen-activated protein kinase activity induced by CP 55,940 in the CHO cell line expressing human brain cannabinoid receptor (IC50 = 9.6 nM) but was inactive in cells expressing hCB2.
Positive_regulation (induced) of Gene_expression (expressing) of cannabinoid receptor in brain associated with cannabinoid receptor
11) Confidence 0.05 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15131245 Disease Relevance 0.07 Pain Relevance 0.27

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