INT81495

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 14.62
Pain Relevance 14.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CNR2) signal transducer activity (CNR2)
Anatomy Link Frequency
blood 1
immune cell 1
liver 1
spinal cord 1
stellate cells 1
CNR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Cannabinoid 372 100.00 Very High Very High Very High
Cannabinoid receptor 157 100.00 Very High Very High Very High
Analgesic 41 100.00 Very High Very High Very High
agonist 171 99.96 Very High Very High Very High
Endocannabinoid 240 99.86 Very High Very High Very High
allodynia 9 99.82 Very High Very High Very High
Neuronal excitability 1 99.80 Very High Very High Very High
dorsal root ganglion 3 99.56 Very High Very High Very High
vincristine 2 99.46 Very High Very High Very High
fibrosis 24 99.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nicotine Addiction 20 99.98 Very High Very High Very High
Inflammatory Bowel Disease 109 99.84 Very High Very High Very High
Neuropathic Pain 53 99.82 Very High Very High Very High
Cirrhosis 30 99.82 Very High Very High Very High
Cancer 203 99.78 Very High Very High Very High
Ganglion Cysts 31 99.56 Very High Very High Very High
Fibrosis 23 99.40 Very High Very High Very High
Apoptosis 44 98.92 Very High Very High Very High
Injury 3 98.24 Very High Very High Very High
Neuroma 1 97.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cannabinoid drugs exert their effects primarily through activation of cannabinoid CB1 and CB2 receptors.
Positive_regulation (activation) of CB2 associated with cannabinoid
1) Confidence 0.67 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2923338 Disease Relevance 1.65 Pain Relevance 0.52
We recently found that N-alkyl amides from purple coneflower (Echinacea spp.) constitute a new class of cannabinomimetics, which specifically engage and activate the cannabinoid type-2 (CB2) receptors.
Positive_regulation (activate) of CB2 associated with cannabinoid
2) Confidence 0.64 Published 2006 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 17118807 Disease Relevance 0.14 Pain Relevance 0.46
We recently found that N-alkyl amides from purple coneflower (Echinacea spp.) constitute a new class of cannabinomimetics, which specifically engage and activate the cannabinoid type-2 (CB2) receptors.
Positive_regulation (activate) of cannabinoid type-2 associated with cannabinoid
3) Confidence 0.56 Published 2006 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 17118807 Disease Relevance 0.14 Pain Relevance 0.46
Interestingly, severe clinic score patients showed no significant increase in CB2 receptors, and this fact correlates with a lack of increased 2-AG turnover (no increases of synthesizing- and degrading enzymes), thus suggesting a diminished ECS response to the inflammatory insult.
Neg (no) Positive_regulation (increase) of CB2 associated with inflammation
4) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.65 Pain Relevance 0.15
In addition, it has been shown that chronic marijuana smoking increases CB1R and CB2R mRNA in peripheral blood mononuclear cells [8].
Positive_regulation (increases) of CB2R in blood associated with nicotine addiction
5) Confidence 0.53 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.10 Pain Relevance 0.23
In contrast to these results, Julien et al.[33] have found in experimentally induced liver cirrhosis that an activation of the CB2 receptor on hepatic stellate cells leads to apoptosis and attenuated liver fibrosis progression.
Positive_regulation (activation) of CB2 in liver associated with fibrosis, cirrhosis and apoptosis
6) Confidence 0.52 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 1.41 Pain Relevance 0.55
Activation of CB1 receptors is associated predominantly with a dampening down of neuronal excitability, whereas activation of CB2 receptors is associated with decreases in immune cell function, including attenuated cytokine release [9,17].
Positive_regulation (activation) of CB2 in immune cell associated with neuronal excitability and cytokine
7) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.69 Pain Relevance 0.74
This effect was antagonized by SR 141716A, suggesting the involvement of the CB1 receptor, although the participation of CB2 receptors cannot be excluded from this study.
Positive_regulation (participation) of CB2
8) Confidence 0.49 Published 2005 Journal Pain Section Abstract Doc Link 16213089 Disease Relevance 0.61 Pain Relevance 0.71
Based on the finding that certain endocannabinoid-like fatty acid N-alkylamides from purple coneflower ( ECHINACEA spp.) potently activate CB2 cannabinoid receptors we have focused our interest on plant fatty acid amides (FAAs) and their overall cannabinomodulatory effects.
Positive_regulation (activate) of CB2 associated with endocannabinoid and cannabinoid receptor
9) Confidence 0.49 Published 2008 Journal Planta Med. Section Abstract Doc Link 18275004 Disease Relevance 0.25 Pain Relevance 0.60
It has been reported that cannabinoids can inhibit the release of CGRP by stimulation of CB1 and CB2 cannabinoid receptors.
Positive_regulation (stimulation) of CB2 associated with cannabinoid receptor and cannabinoid
10) Confidence 0.49 Published 2001 Journal Farmaco Section Abstract Doc Link 11482756 Disease Relevance 0.23 Pain Relevance 0.61
Regarding the cannabinoid receptors in treated UC, the acute CB2 increase in UC patients is reverted in the chronic state, irrespective of the treatment.
Positive_regulation (increase) of CB2 associated with inflammatory bowel disease and cannabinoid receptor
11) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.79 Pain Relevance 0.24
Here, we demonstrate colocalisation of CB2 with CB1 and the capsaicin receptor TRPV1 in human dorsal root ganglion (DRG) sensory neurons and increased levels of CB2 receptors in human peripheral nerves after injury, particularly painful neuromas.
Positive_regulation (increased) of CB2 in DRG associated with ganglion cysts, pain, dorsal root ganglion, qutenza, injury and neuroma
12) Confidence 0.46 Published 2008 Journal Pain Section Abstract Doc Link 18692962 Disease Relevance 0.72 Pain Relevance 1.17
Stimulation of peripheral cannabinoid receptor CB2 induces MCP-1 and IL-8 gene expression in human promyelocytic cell line HL60.
Positive_regulation (Stimulation) of CB2 associated with cannabinoid receptor and analgesic
13) Confidence 0.45 Published 1999 Journal FEBS Lett. Section Title Doc Link 10218491 Disease Relevance 0.05 Pain Relevance 0.49
Consistently, in vivo studies have shown that cannabinoids reduce gastrointestinal transit in rodents through activation of CB1, but not CB2, receptors.
Positive_regulation (activation) of CB2 associated with cannabinoid
14) Confidence 0.43 Published 2008 Journal Eur Rev Med Pharmacol Sci Section Abstract Doc Link 18924447 Disease Relevance 0.51 Pain Relevance 0.57
However, there is little direct structural information pertaining to either GPCR or CB2-receptor ligand recognition and activation.
Positive_regulation (activation) of CB2
15) Confidence 0.41 Published 2008 Journal Chem. Biol. Section Abstract Doc Link 19022181 Disease Relevance 0.29 Pain Relevance 0.23
As shown in Fig. 2A, upon polyclonal stimulation with anti-CD3 and anti-CD28, T-lymphocytes showed a significant increase in CB1R and CB2R, with the levels of the latter being significantly higher than those of CB1R.
Positive_regulation (increase) of CB2R in T-lymphocytes
16) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.12
Quantification of epithelial immunoreactivity showed an increase of CB2 receptor, DAGL?
Positive_regulation (increase) of CB2
17) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2731878 Disease Relevance 0.25 Pain Relevance 0.42
However, the increased ratio in acute samples was due to an increase of CB2 receptors [1.22±0.04 vs 1.06±0.02; p<0.01] whereas in quiescent samples it was derived from a downregulation of CB1 receptors [1.23±0.039 vs 1.06±0.02; p<0.001].
Positive_regulation (increase) of CB2
18) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.23 Pain Relevance 0.05
AEA exerts its action through binding and activation of cannabinoid receptors, CB1R and CB2R [3].
Positive_regulation (activation) of CB2R associated with cannabinoid receptor
19) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0 Pain Relevance 0.22
For liver cirrhosis it has recently been shown that CB2-receptor activation mediated anti-fibrosis by apoptosis induction and growth inhibition of hepatic stellate cells [33].
Positive_regulation (activation) of CB2-receptor in stellate cells associated with fibrosis, cirrhosis and apoptosis
20) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 1.50 Pain Relevance 1.17

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