INT81497

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Context Info
Confidence 0.63
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.00
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
coronary artery 2
monocyte 2
dorsal root ganglion 2
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 8 99.80 Very High Very High Very High
dorsal root ganglion 4 99.54 Very High Very High Very High
Inflammation 34 99.40 Very High Very High Very High
Cannabinoid receptor 7 97.28 Very High Very High Very High
chemokine 13 90.44 High High
Cannabinoid 4 88.76 High High
antagonist 1 78.08 Quite High
Inflammatory response 1 61.76 Quite High
Action potential 1 56.40 Quite High
Angina 1 34.00 Quite Low
Disease Link Frequency Relevance Heat
Injury 1 99.88 Very High Very High Very High
Ganglion Cysts 5 99.54 Very High Very High Very High
INFLAMMATION 36 99.40 Very High Very High Very High
Bordatella Infection 1 98.40 Very High Very High Very High
Nociception 3 97.78 Very High Very High Very High
Atherosclerosis 2 96.96 Very High Very High Very High
Asthma 69 95.72 Very High Very High Very High
Coronary Artery Disease 8 93.04 High High
Death 1 35.48 Quite Low
Cv General 3 Under Development 1 34.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The enhancement of IL-8 and MCP-1 gene transcription and protein production was shown to be pertussis toxin sensitive attesting that this phenomenon was a Gi protein-coupled receptor-mediated process as expected for cannabinoid receptors.
Positive_regulation (enhancement) of Transcription (transcription) of MCP-1 associated with bordatella infection and cannabinoid receptor
1) Confidence 0.63 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0.10 Pain Relevance 0.67
Previous experimental results from our laboratory demonstrated that monocyte chemoattractant protein-1 (MCP-1) depolarizes or increases the excitability of nociceptive neurons in the intact dorsal root ganglion (DRG) after a chronic compression of the DRG (CCD), an injury that upregulates neuronal expression of both MCP-1 and mRNA for its receptor CCR2.
Positive_regulation (upregulates) of in dorsal root ganglion Transcription (expression) of MCP-1 in DRG associated with ganglion cysts, nociception, dorsal root ganglion and injury
2) Confidence 0.44 Published 2006 Journal J. Neurophysiol. Section Abstract Doc Link 16775210 Disease Relevance 0.81 Pain Relevance 0.22
We evaluated mRNA expression and protein production of CCL2, CXCL8, CXCL9, CXCL10, IFN-gamma and IL-10 in vitro as well as the expression of the CCR2 and CXCR3 receptors in peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease (CAD) and healthy controls in the presence or absence of oxidized LDL (oxLDL).
Positive_regulation (evaluated) of Transcription (expression) of CCL2 in coronary artery associated with coronary artery disease
3) Confidence 0.17 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18617279 Disease Relevance 0.69 Pain Relevance 0.26
Recently, increased expression of eotaxin and monocyte chemotactic protein-4 mRNA has been reported in the epithelial cell layer (Fig. 5) and in the airway wall of small airways of asthmatic persons as compared with nonasthmatic control individuals [6].
Positive_regulation (increased) of Transcription (expression) of monocyte chemotactic protein in monocyte associated with asthma
4) Confidence 0.04 Published 2001 Journal Respir Res Section Body Doc Link PMC64806 Disease Relevance 0.41 Pain Relevance 0.10

General Comments

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