INT81498

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 10
Speculated 3
Reported most in Body
Documents 107
Total Number 110
Disease Relevance 53.89
Pain Relevance 45.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CCL2) extracellular space (CCL2) aging (CCL2)
extracellular region (CCL2) cell adhesion (CCL2) cytoskeleton organization (CCL2)
Anatomy Link Frequency
monocyte 40
plasma 12
neurons 12
astrocytes 12
endothelial cells 10
CCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1381 100.00 Very High Very High Very High
cytokine 823 100.00 Very High Very High Very High
chemokine 736 100.00 Very High Very High Very High
Morphine 1011 99.98 Very High Very High Very High
opioid receptor 301 99.98 Very High Very High Very High
Angina 28 99.92 Very High Very High Very High
Cannabinoid receptor 49 99.90 Very High Very High Very High
lidocaine 24 99.90 Very High Very High Very High
Chronic pancreatitis 66 99.86 Very High Very High Very High
Fibrositis 291 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1551 100.00 Very High Very High Very High
Adhesions 198 100.00 Very High Very High Very High
Viral Meningitis 81 100.00 Very High Very High Very High
Renal Disease 129 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 168 99.92 Very High Very High Very High
Cv General 3 Under Development 34 99.92 Very High Very High Very High
Pancreatitis 67 99.86 Very High Very High Very High
Fibromyalgia 291 99.84 Very High Very High Very High
Primary Sclerosing Cholangitis 154 99.84 Very High Very High Very High
Breast Cancer 5 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine inhibited lipopolysaccharide-induced MCP-1 production as well as messenger RNA expression in a dose-dependent manner.
Positive_regulation (induced) of Gene_expression (production) of MCP-1 associated with lidocaine
1) Confidence 0.70 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.40 Pain Relevance 0.71
Lidocaine may modulate MCP-1-induced monocyte response, as reflected by chemotaxis, cytosolic-free calcium, and lipopolysaccharide-induced MCP-1 production by human monocytic THP-1 cells.
Positive_regulation (induced) of Gene_expression (production) of MCP-1 in THP-1 associated with lidocaine
2) Confidence 0.70 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.39 Pain Relevance 0.68
However, this study demonstrated for the first time that morphine can stimulate production of CCL2 by human neurons.
Positive_regulation (stimulate) of Gene_expression (production) of CCL2 in neurons associated with morphine
3) Confidence 0.70 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.08 Pain Relevance 1.00
Taken together, the findings in this study support the hypothesis that morphine stimulates CCL2 expression by human neurons and add another mechanism to a growing repertoire whereby opiates could alter the neuroinflammatory process.


Positive_regulation (stimulates) of Gene_expression (expression) of CCL2 in neurons associated with opiate and morphine
4) Confidence 0.70 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.47 Pain Relevance 0.73
Since accelerated atherosclerosis is the main complication of diabetes and both diseases encompass an inflammatory reaction, we hypothesized that the anti-inflammatory drugs, aspirin and peroxisome proliferator-activated receptor (PPAR-alpha) activators (fenofibrate and clofibrate), could have an effect on the high glucose-induced MCP-1 expression in endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of MCP-1 in endothelial cells associated with aspirin, inflammation, diabetes mellitus, cinod, disease and increased venous pressure under development
5) Confidence 0.67 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.56 Pain Relevance 0.34
Using the recently developed methodology of nucleic acid microarrays spotted with specific cDNAs probes belonging to different gene families, we showed for the first time that nanomolar concentrations of the cannabinoid ligand CP-55940 upregulated the expression of two different members of the chemokine gene family: the alpha-chemokine interleukin-8 (IL-8) and the beta-chemokine monocyte chemotactic protein-1 (MCP-1), in the promyelocytic cell line HL60 transfected with peripheral cannabinoid receptors (CB2).
Positive_regulation (upregulated) of Gene_expression (expression) of beta-chemokine monocyte chemotactic protein-1 in monocyte associated with chemokine, cannabinoid receptor and cannabinoid
6) Confidence 0.63 Published 1999 Journal FEBS Lett. Section Abstract Doc Link 10218491 Disease Relevance 0 Pain Relevance 0.44
Increased plasma antigen levels of monocyte chemoattractant protein-1 in patients with restenosis after percutaneous transluminal coronary angioplasty.
Positive_regulation (Increased) of Gene_expression (levels) of monocyte chemoattractant protein-1 in plasma associated with cardiovascular disease and percutaneous transluminal coronary angioplasty
7) Confidence 0.59 Published 2000 Journal Jpn. Circ. J. Section Title Doc Link 11110426 Disease Relevance 0.72 Pain Relevance 0.38
Aspirin and PPAR-alpha activators inhibit monocyte chemoattractant protein-1 expression induced by high glucose concentration in human endothelial cells.
Positive_regulation (induced) of Gene_expression (expression) of chemoattractant protein-1 in endothelial cells associated with aspirin
8) Confidence 0.58 Published 2006 Journal Vascul. Pharmacol. Section Title Doc Link 16600694 Disease Relevance 0.52 Pain Relevance 0.37
On the other hand, canine cardiovascular conditions are associated with overexpression of CCL2 and CXCL8.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CCL2 associated with viral meningitis
9) Confidence 0.55 Published 2002 Journal Vet. Immunol. Immunopathol. Section Abstract Doc Link 12007879 Disease Relevance 1.13 Pain Relevance 0.69
These results suggest that lidocaine may modulate MCP-1 production and MCP-1-induced activation in inflammatory cells.
Spec (may) Positive_regulation (modulate) of Gene_expression (production) of MCP-1 associated with inflammation and lidocaine
10) Confidence 0.50 Published 2003 Journal Anesth. Analg. Section Abstract Doc Link 14570645 Disease Relevance 0.42 Pain Relevance 0.74
In the course of testing the hypothesis that morphine would stimulate CCL2 production by neurons, three observations were made: 1) CCL2, which was the only chemokine examined that was constitutively expressed by neurons under our experimental conditions, was significantly upregulated in neurons by exposure to morphine; 2) morphine's enhancement of CCL2 was specific for neurons, as witnessed by a lack of response of astrocytes and microglia to morphine under our experimental conditions; and 3) morphine's potentiation of neuronal CCL2 production involves the MOR.
Positive_regulation (stimulate) of Gene_expression (production) of CCL2 in astrocytes associated with chemokine, opioid receptor and morphine
11) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0 Pain Relevance 1.31
In the course of testing the hypothesis that morphine would stimulate CCL2 production by neurons, three observations were made: 1) CCL2, which was the only chemokine examined that was constitutively expressed by neurons under our experimental conditions, was significantly upregulated in neurons by exposure to morphine; 2) morphine's enhancement of CCL2 was specific for neurons, as witnessed by a lack of response of astrocytes and microglia to morphine under our experimental conditions; and 3) morphine's potentiation of neuronal CCL2 production involves the MOR.
Positive_regulation (potentiation) of Gene_expression (production) of CCL2 in astrocytes associated with chemokine, opioid receptor and morphine
12) Confidence 0.50 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1712222 Disease Relevance 0.05 Pain Relevance 1.09
not prove to have a significant effect on circulating MCP-1 concentrations in
Positive_regulation (circulating) of Gene_expression (concentrations) of MCP-1
13) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.06 Pain Relevance 0
Relatively, a recent report documented significantly higher MCP-1
Positive_regulation (higher) of Gene_expression (higher) of MCP-1
14) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.05 Pain Relevance 0
Relatively, a recent report documented significantly higher MCP-1
Positive_regulation (documented) of Gene_expression (higher) of MCP-1
15) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.05 Pain Relevance 0
demonstrated significantly elevated MCP-1 concentrations in preeclamptic
Positive_regulation (elevated) of Gene_expression (concentrations) of MCP-1
16) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.42 Pain Relevance 0
based on the hypothesis that circulating concentrations of MCP-1 might differ
Positive_regulation (concentrations) of Gene_expression (concentrations) of MCP-1
17) Confidence 0.50 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2234089 Disease Relevance 0.19 Pain Relevance 0.13
These data suggest that the MCP-1 production and macrophage accumulation in the balloon-injured site is partially associated with restenosis after PTCA.
Positive_regulation (accumulation) of Gene_expression (production) of MCP-1 in macrophage associated with cardiovascular disease and percutaneous transluminal coronary angioplasty
18) Confidence 0.49 Published 2000 Journal Jpn. Circ. J. Section Abstract Doc Link 11110426 Disease Relevance 0.76 Pain Relevance 0.44
Production of MCP-1 and macrophage accumulation are also observed after coronary angioplasty or grafting, indicating that MCP-1 expression may be related not only to instability of atheromatous plaques, but also to the formation of restenotic lesions.
Positive_regulation (accumulation) of Gene_expression (Production) of MCP-1 in macrophage associated with atherosclerotic plaque
19) Confidence 0.49 Published 2002 Journal Clin Cardiol Section Abstract Doc Link 12000070 Disease Relevance 0.78 Pain Relevance 0.24
Together, the findings indicate that in endothelial cells aspirin and PPAR-alpha activators reduce the high glucose-increased expression of MCP-1 by a mechanism that includes the inhibition of reactive oxygen species, and decrease of AP-1 and NF-kB activation.
Positive_regulation (glucose-increased) of Gene_expression (expression) of MCP-1 in endothelial cells associated with aspirin
20) Confidence 0.48 Published 2006 Journal Vascul. Pharmacol. Section Abstract Doc Link 16600694 Disease Relevance 0.10 Pain Relevance 0.27

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