INT81500

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Context Info
Confidence 0.66
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.12
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
cleavage 3
neurons 1
muscles 1
synapse 1
cortex 1
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neurotransmitter 15 99.68 Very High Very High Very High
addiction 1 99.00 Very High Very High Very High
bradykinin 3 98.28 Very High Very High Very High
Desipramine 7 97.84 Very High Very High Very High
qutenza 3 97.72 Very High Very High Very High
Glutamate 14 97.04 Very High Very High Very High
Hippocampus 7 96.16 Very High Very High Very High
tetrodotoxin 11 95.32 Very High Very High Very High
Kinase C 4 91.48 High High
Pain 4 87.52 High High
Disease Link Frequency Relevance Heat
Poisoning 3 88.64 High High
Pain 3 87.52 High High
Wrinkles 2 86.44 High High
Clostridium Infection 3 81.12 Quite High
Nociception 3 80.64 Quite High
Headache 1 78.52 Quite High
Inflammatory Pain 1 77.52 Quite High
Depression 6 52.52 Quite High
Affective Disorder 1 51.76 Quite High
Targeted Disruption 4 13.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cleaved SNAP-25 also appeared in the facial nucleus after injection of the toxin into rat whisker muscles.
Protein_catabolism (Cleaved) of SNAP-25 in muscles
1) Confidence 0.66 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18385327 Disease Relevance 0.14 Pain Relevance 0.15
SNAP-25 cleavage by BoNT/A was observed in the contralateral hemisphere after unilateral BoNT/A delivery to the hippocampus.
Protein_catabolism (cleavage) of SNAP-25 in hippocampus associated with hippocampus
2) Confidence 0.66 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18385327 Disease Relevance 0.17 Pain Relevance 0.17
This presynaptic modulation requires SNARE proteins because cleavage of SNAP-25 with the botulinum neurotoxin A strongly reduced the desipramine-induced glutamate release.
Protein_catabolism (cleavage) of SNAP-25 in cleavage associated with glutamate and desipramine
3) Confidence 0.63 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218774 Disease Relevance 0.10 Pain Relevance 0.98
Therefore, SNAP-25 cleavage in the visual cortex would persist for at least 1 week following BoNT/E injection.
Protein_catabolism (cleavage) of SNAP-25 in cortex
4) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0.09 Pain Relevance 0
BoNT/E is a metalloprotease that selectively cleaves the synaptic protein SNAP-25 and prevents transmitter release [12], [13].
Protein_catabolism (cleaves) of SNAP-25
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0 Pain Relevance 0
To estimate the duration of BoNT/E effects, we analyzed the time course of SNAP-25 cleavage after a single BoNT/E injection into the visual cortex.
Protein_catabolism (cleavage) of SNAP-25 in cleavage
6) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2614467 Disease Relevance 0 Pain Relevance 0.03
Botulinum neurotoxin (BoNT) type A cleaved SNAP25 and inhibited release triggered by K(+) > bradykinin >> capsaicin.
Protein_catabolism (cleaved) of SNAP25 associated with qutenza and bradykinin
7) Confidence 0.30 Published 2007 Journal J. Cell. Sci. Section Abstract Doc Link 17666428 Disease Relevance 0.23 Pain Relevance 0.49
Figure S2 shows that application of sphingosine to neurons impeded proteolysis of synaptobrevin and SNAP-25 by the neurotoxins demonstrating upregulation of SNARE assembly.


Protein_catabolism (proteolysis) of SNAP-25 in neurons
8) Confidence 0.25 Published 2009 Journal Neuron Section Body Doc Link PMC2697323 Disease Relevance 0 Pain Relevance 0
, TAX1BP1, drebrin, SNAP-25), which may modulate proteolysis in a synapse-specific manner. 14-3-3?
Protein_catabolism (proteolysis) of SNAP-25 in synapse
9) Confidence 0.15 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0 Pain Relevance 0
Furthermore, the dependence of inhibition of neurotransmitter release on the cleavage of SNAP-25 is demonstrated through the use of an endopeptidase-deficient LH(N)/A conjugate variant.
Protein_catabolism (cleavage) of SNAP-25 in cleavage associated with addiction and neurotransmitter
10) Confidence 0.11 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12105193 Disease Relevance 0.38 Pain Relevance 0.29

General Comments

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