INT81501

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Context Info
Confidence 0.30
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.10
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
cleavage 2
Snap25 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Desipramine 7 99.80 Very High Very High Very High
Glutamate 3 99.00 Very High Very High Very High
tetrodotoxin 2 95.32 Very High Very High Very High
Kinase C 4 91.48 High High
Neurotransmitter 1 91.44 High High
tricyclic antidepressant 3 83.60 Quite High
Hippocampus 1 75.00 Quite High
noradrenaline 1 56.80 Quite High
Serotonin 1 56.08 Quite High
monoamine 1 55.68 Quite High
Disease Link Frequency Relevance Heat
Depression 1 52.52 Quite High
Affective Disorder 1 51.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This presynaptic modulation requires SNARE proteins because cleavage of SNAP-25 with the botulinum neurotoxin A strongly reduced the desipramine-induced glutamate release.
Negative_regulation (reduced) of Protein_catabolism (cleavage) of SNAP-25 in cleavage associated with glutamate and desipramine
1) Confidence 0.30 Published 1999 Journal Neuroscience Section Abstract Doc Link 10218774 Disease Relevance 0.10 Pain Relevance 0.99

General Comments

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