INT8152

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Context Info
Confidence 0.58
First Reported 1992
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 40
Total Number 57
Disease Relevance 19.90
Pain Relevance 46.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Vta1)
Anatomy Link Frequency
neurons 8
dopamine neurons 4
brain 3
DA neurons 2
neuronal 2
Vta1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 2520 100.00 Very High Very High Very High
Dopamine 1870 100.00 Very High Very High Very High
depression 1636 100.00 Very High Very High Very High
Cannabinoid 972 100.00 Very High Very High Very High
gABA 306 100.00 Very High Very High Very High
Nucleus accumbens 292 100.00 Very High Very High Very High
midbrain 168 100.00 Very High Very High Very High
Glutamate 144 100.00 Very High Very High Very High
Thalamus 42 100.00 Very High Very High Very High
long-term potentiation 480 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 1649 100.00 Very High Very High Very High
Cold Sores 8 100.00 Very High Very High Very High
Stress 62 99.96 Very High Very High Very High
Parkinson's Disease 55 99.72 Very High Very High Very High
Herpes Simplex Virus 6 99.36 Very High Very High Very High
Li-fraumeni Syndrome 288 99.32 Very High Very High Very High
Urological Neuroanatomy 13 99.28 Very High Very High Very High
Disease 174 99.14 Very High Very High Very High
Syndrome 8 97.84 Very High Very High Very High
Sprains And Strains 26 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ingestion of amniotic fluid (and therefore POEF) facilitated the onset of maternal behavior in rats receiving an intra-VTA microinjection of an otherwise subthreshold dose of morphine (0.01 microg).
Gene_expression (microinjection) of VTA in amniotic fluid associated with ventral tegmentum and morphine
1) Confidence 0.58 Published 2009 Journal Brain Res. Section Abstract Doc Link 19401160 Disease Relevance 0.10 Pain Relevance 0.81
In contrast, microinjections of the kappa agonist U50,488H and the dynorphin derivative E-2078 into the VTA produced place aversions.
Gene_expression (produced) of VTA associated with ventral tegmentum, dynorphin and agonist
2) Confidence 0.52 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8093731 Disease Relevance 0 Pain Relevance 0.81
Identifying precisely how these lesions influence the dynamics of neuronal interactions in the VTA—do they affect a direct nicotinic activation of DA neurons or is the effect mediated through GABA?
Gene_expression (do) of VTA in DA neurons associated with ventral tegmentum, gaba and dopamine
3) Confidence 0.48 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.54
It has been proposed that the primary effect of nicotine in the VTA is on GABA and glutamate containing terminals, with a direct action on DA neurons themselves being of lesser importance (Mansvelder et al. 2002).
Gene_expression (is) of VTA in DA neurons associated with ventral tegmentum, dopamine, glutamate, gaba and nicotine
4) Confidence 0.48 Published 2008 Journal Brain Struct Funct Section Body Doc Link PMC2522332 Disease Relevance 0 Pain Relevance 0.87
All three MPD doses attenuated the amplitude of the field potential components (P2, N2, and P3) as compared to those of baseline in the VTA, NAc, and PFC neurons.
Gene_expression (neurons) of VTA in neurons associated with nucleus accumbens and ventral tegmentum
5) Confidence 0.45 Published 2006 Journal Behav Brain Funct Section Body Doc Link PMC1360669 Disease Relevance 0 Pain Relevance 0.32
In addition, in vivo microdialysis studies have demonstrated that intra-VTA administration of the GABAB receptor agonist baclofen decreases extracellular dopamine levels in both the somatodendritic [32,33] and the axon-terminal regions of the mesocorticolimbic system [15,16].
Gene_expression (administration) of VTA associated with ventral tegmentum, dopamine and agonist
6) Confidence 0.38 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 1.03
Immunohistochemistry was performed on naïve rat brain during preliminary experiments aimed at characterising the exact orientation of the cutting for the dissection of the VTA (Figure 1).
Gene_expression (dissection) of VTA in brain associated with ventral tegmentum
7) Confidence 0.38 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0.10 Pain Relevance 0.14
The procedure used for the dissection of the VTA is illustrated in Figure 1, which shows a photomicrogaph of a representative coronal slice immunohistochemically stained for tyrosine hydroxylase.
Gene_expression (dissection) of VTA associated with ventral tegmentum
8) Confidence 0.38 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0.06 Pain Relevance 0.24
In contrast, intra-mPfc TTX decreased local GABA (-33+6%) while VTA GABA levels were not affected.
Gene_expression (levels) of VTA associated with ventral tegmentum and gaba
9) Confidence 0.36 Published 2002 Journal J. Neurosci. Methods Section Abstract Doc Link 12323414 Disease Relevance 0 Pain Relevance 1.13
These regions, which are closely connected with both the SuM and VTA and expressed picrotoxin-induced c-Fos, have been previously implicated in positive motivational processes.
Gene_expression (connected) of VTA associated with ventral tegmentum
10) Confidence 0.32 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.66
Because the preoptic nuclei are closely connected with the SuM, VTA and the above-mentioned regions that showed significant c-Fos expression, these nuclei could play an important role in motivational processes initiated through the SuM.
Gene_expression (expression) of VTA associated with ventral tegmentum
11) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.49
We now report that in rats given HSV-GluR1 directly into the VTA, morphine is most rewarding when maximal transgene expression is in the rostral VTA, whereas morphine is aversive when maximal transgene expression is in the caudal VTA.
Gene_expression (expression) of VTA associated with ventral tegmentum, cold sores and morphine
12) Confidence 0.28 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.50 Pain Relevance 1.16
Microinjections of a herpes simplex virus (HSV) vector that causes local overexpression of GluR1 (HSV-GluR1) into the VTA can enhance the ability of morphine to establish conditioned place preferences, suggesting that altered GluR1 expression in this region is directly associated with changes in the rewarding efficacy of morphine.
Gene_expression (overexpression) of VTA associated with ventral tegmentum, cold sores, herpes simplex virus and morphine
13) Confidence 0.28 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10684909 Disease Relevance 0.45 Pain Relevance 1.01
Captopril (30 mug) and Ang II (0.25 nmol) were injected into the VTA in the corresponding groups before each session.
Gene_expression (injected) of VTA
14) Confidence 0.28 Published 2009 Journal Acta. Biol. Hung. Section Abstract Doc Link 19700383 Disease Relevance 0 Pain Relevance 0.64
We observed the pattern of c-Fos expression in the VTA and the ventral striatum paralleled with the connectivity between the VTA and ventral striatum.
Gene_expression (expression) of VTA in striatum associated with ventral tegmentum
15) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.38
In addition to the medial mesolimbic dopamine system, we observed increased expression of c-Fos in other regions that are closely connected with both the SuM and VTA.
Gene_expression (connected) of VTA in medial associated with ventral tegmentum and dopamine
16) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.48
The posterior VTA has been shown to predominantly project to the medial part of the ventral striatum, including the medial shell, while the anterolateral VTA largely projects to the lateral part of the ventral striatum, including the core [17].
Gene_expression (project) of VTA in shell associated with ventral tegmentum
17) Confidence 0.28 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2930627 Disease Relevance 0 Pain Relevance 0.47
In contrast to NFs, no P-NP line differences were found in VTA levels of tyrosine hydroxylase, which is also regulated by chronic morphine and cocaine treatments in Sprague-Dawley rats and shows prominent Lewis-Fischer strain differences, specifically in this brain region.
Gene_expression (levels) of VTA in brain associated with ventral tegmentum, sprains and strains, cocaine and morphine
18) Confidence 0.28 Published 1993 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 8101433 Disease Relevance 0.25 Pain Relevance 1.02
Unlike cocaine, morphine, and stress, repeated treatment with other psychotropic drugs (haloperidol, raclopride, sertraline, and desipramine) that lack reinforcing or sensitizing properties did not regulate GluR1 or NMDAR1 subunit levels in the VTA.
Gene_expression (levels) of VTA associated with stress, ventral tegmentum, desipramine, morphine and cocaine
19) Confidence 0.25 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.40 Pain Relevance 1.00
Increased glutamate receptor subunit expression in the VTA may represent an important molecular mechanism by which drugs of abuse and stress exert common, long-term effects on mesolimbic DA function.
Gene_expression (expression) of VTA associated with stress, ventral tegmentum, dopamine and glutamate receptor
20) Confidence 0.25 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8613793 Disease Relevance 0.48 Pain Relevance 0.93

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