INT8153

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Context Info
Confidence 0.62
First Reported 1982
Last Reported 2010
Negated 11
Speculated 10
Reported most in Abstract
Documents 52
Total Number 61
Disease Relevance 11.22
Pain Relevance 54.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cck) extracellular region (Cck)
Anatomy Link Frequency
ACC 10
spinal 8
vagal nerves 4
dorsal horn 4
hypothalamus 3
Cck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Cholecystokinin 432 100.00 Very High Very High Very High
Morphine 110 100.00 Very High Very High Very High
narcan 69 100.00 Very High Very High Very High
Opioid 45 100.00 Very High Very High Very High
opiate 33 100.00 Very High Very High Very High
Dopamine 24 100.00 Very High Very High Very High
Somatostatin 23 100.00 Very High Very High Very High
Pain 21 100.00 Very High Very High Very High
anesthesia 20 100.00 Very High Very High Very High
substance P 19 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 29 100.00 Very High Very High Very High
Pain 21 100.00 Very High Very High Very High
Hypersensitivity 4 100.00 Very High Very High Very High
Neuropathic Pain 10 99.68 Very High Very High Very High
Ganglion Cysts 3 99.68 Very High Very High Very High
Pancreatitis 41 99.40 Very High Very High Very High
Arthritis 14 99.24 Very High Very High Very High
Bardet-biedl Syndrome 4 99.04 Very High Very High Very High
Inflammatory Pain 1 98.66 Very High Very High Very High
Fistula 2 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of cholecystokinin release from rat caudatoputamen in vitro.
Regulation (regulation) of Localization (release) of cholecystokinin associated with cholecystokinin
1) Confidence 0.62 Published 1987 Journal Brain Res. Section Title Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.85
The present study has examined the influence of other neuroactive substances on the release of CCK.
Spec (examined) Regulation (influence) of Localization (release) of CCK associated with cholecystokinin
2) Confidence 0.62 Published 1987 Journal Brain Res. Section Abstract Doc Link 2884011 Disease Relevance 0 Pain Relevance 0.82
The effect of morphine-pellet implantation on basal and K+-induced release of CCK-like immunoreactivity (CCK-LI) in the rat dorsal horn were monitored with in vivo microdialysis 96 h after implantation of morphine or placebo pellets, when rats showed tolerance and dependence.
Regulation (effect) of Localization (release) of CCK in dorsal horn associated with addiction, tolerance, dorsal horn and morphine
3) Confidence 0.62 Published 1999 Journal Brain Res. Section Abstract Doc Link 10064790 Disease Relevance 0 Pain Relevance 1.56
Perifusion of dispersed mucosal cells constitutes a reproducible model to investigate hormonal and peptidergic regulation of CCK release in vitro.
Spec (investigate) Regulation (regulation) of Localization (release) of CCK associated with cholecystokinin
4) Confidence 0.62 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8338159 Disease Relevance 0 Pain Relevance 0.45
These studies indicate a regional specificity for the effect of opiates on CCK release, and may provide evidence for a cellular mechanism by which endogenous opiates modulate feeding behavior.
Regulation (effect) of Localization (release) of CCK associated with opiate and cholecystokinin
5) Confidence 0.62 Published 1985 Journal Brain Res. Section Abstract Doc Link 3896389 Disease Relevance 0.42 Pain Relevance 1.01
Given a hypothesised role for CCK in the anterior cingulate cortex (ACC) for the sensation of pain, the aim of the present study was to investigate whether the increased CCK release could be affected by two different analgesic drugs, morphine and the non-selective cyclooxygenase inhibitor diclofenac.
Regulation (affected) of Localization (release) of CCK in cingulate cortex associated with pain, analgesic, diclofenac, anterior cingulate cortex and morphine
6) Confidence 0.62 Published 2007 Journal Brain Res. Section Abstract Doc Link 17229410 Disease Relevance 0.32 Pain Relevance 1.02
Neither diclofenac (25 mg/kg i.m.) nor morphine (5 or 10 mg/kg s.c.) affected the CCK-LI release in the ACC in non-arthritic rats.
Neg (Neither) Regulation (affected) of Localization (release) of CCK in ACC associated with anterior cingulate cortex, diclofenac, arthritis and morphine
7) Confidence 0.62 Published 2007 Journal Brain Res. Section Abstract Doc Link 17229410 Disease Relevance 0.55 Pain Relevance 1.66
[The role of opioid peptides in regulation of cholecystokinin-stimulated bile secretion].
Regulation (regulation) of Localization (secretion) of cholecystokinin in bile associated with bile, cholecystokinin and opioid
8) Confidence 0.62 Published 2006 Journal Ross Fiziol Zh Im I M Sechenova Section Title Doc Link 17385430 Disease Relevance 0 Pain Relevance 0.58
In conclusion: alterations in CCK secretion are observed in patients with chronic pancreatitis and after pancreatic surgery.
Regulation (alterations) of Localization (secretion) of CCK associated with chronic pancreatitis and cholecystokinin
9) Confidence 0.61 Published 1999 Journal Pancreas Section Abstract Doc Link 10438157 Disease Relevance 0.30 Pain Relevance 0.79
Cholecystokinin (CCK) secretion may be affected in patients with chronic pancreatitis (CP), but little is known on the effect of pancreatic surgery on CCK secretion.
Regulation (affected) of Localization (secretion) of Cholecystokinin associated with chronic pancreatitis and cholecystokinin
10) Confidence 0.61 Published 1999 Journal Pancreas Section Abstract Doc Link 10438157 Disease Relevance 0.34 Pain Relevance 0.61
It is unclear whether CCK hypersecretion or hypersensitivity to CCK is responsible for symptoms in dyspeptic patients.
Spec (whether) Regulation (responsible) of Localization (hypersecretion) of CCK associated with hypersensitivity and cholecystokinin
11) Confidence 0.61 Published 2010 Journal Am. J. Gastroenterol. Section Abstract Doc Link 20234343 Disease Relevance 0.34 Pain Relevance 0.56
There is also the potential for local neural mechanisms to regulate CCK release and thereby reduce afferent activation indirectly.
Regulation (regulate) of Localization (release) of CCK in neural
12) Confidence 0.61 Published 2001 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 11123197 Disease Relevance 0.24 Pain Relevance 0.04
These results suggest that the release of CCK in PAG is modulated by opioid systems.
Regulation (modulated) of Localization (release) of CCK associated with periaqueductal grey, opioid and cholecystokinin
13) Confidence 0.61 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3683773 Disease Relevance 0.59 Pain Relevance 1.64
Effect of alcohol on the release of cholecystokinin and pancreatic enzyme secretion.
Regulation (Effect) of Localization (release) of cholecystokinin associated with cholecystokinin and alcohol
14) Confidence 0.60 Published 1984 Journal Am. J. Surg. Section Title Doc Link 6691552 Disease Relevance 0.40 Pain Relevance 0.40
Regulation of cholecystokinin octapeptide secretion by rat cerebral cortical cells in primary culture.
Regulation (Regulation) of Localization (secretion) of cholecystokinin associated with cholecystokinin
15) Confidence 0.60 Published 1991 Journal Endocrinology Section Title Doc Link 1683280 Disease Relevance 0 Pain Relevance 0.38
The effect of the antibodies on CCK-8-stimulated (0.25-2.50 nmol/kg/h) pancreatic amylase secretion was also tested.
Regulation (effect) of Localization (secretion) of CCK
16) Confidence 0.60 Published 1997 Journal J. Physiol. Paris Section Abstract Doc Link 9403799 Disease Relevance 0 Pain Relevance 0.61
The regulation of cholecystokinin octapeptide (CCK-8) secretion was studied using a fetal cerebral cortical cell culture system.
Regulation (regulation) of Localization (secretion) of cholecystokinin associated with cholecystokinin
17) Confidence 0.60 Published 1991 Journal Endocrinology Section Abstract Doc Link 1683280 Disease Relevance 0 Pain Relevance 0.15
Thus, the present study does not support the hypothesis that trypsin is involved in the regulation of CCK release.
Regulation (regulation) of Localization (release) of CCK associated with cholecystokinin
18) Confidence 0.58 Published 1986 Journal Pancreas Section Abstract Doc Link 3562443 Disease Relevance 0.19 Pain Relevance 0.50
These results suggest that the release of accumbal DA and CCK-8 can be differentially regulated by drug treatment.
Regulation (regulated) of Localization (release) of CCK-8 associated with dopamine
19) Confidence 0.54 Published 2000 Journal Synapse Section Abstract Doc Link 11020226 Disease Relevance 0 Pain Relevance 0.63
We have examined the effects of morphine on the potassium-stimulated, calcium-dependent release of SP, CCK and NT from cat hypothalamic slices.
Spec (examined) Regulation (effects) of Localization (release) of CCK associated with cholecystokinin, substance p and morphine
20) Confidence 0.46 Published 1982 Journal Brain Res. Section Abstract Doc Link 6184121 Disease Relevance 0 Pain Relevance 1.13

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