INT81530

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 1
Speculated 4
Reported most in Abstract
Documents 93
Total Number 97
Disease Relevance 48.58
Pain Relevance 32.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
brain 3
spinal nerve 2
spinal 2
blood 2
neutrophil 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 412 100.00 Very High Very High Very High
cytokine 274 100.00 Very High Very High Very High
Inflammatory response 45 100.00 Very High Very High Very High
Pain 75 99.98 Very High Very High Very High
neuralgia 12 99.98 Very High Very High Very High
Inflammatory mediators 9 99.96 Very High Very High Very High
glial activation 2 99.96 Very High Very High Very High
ketamine 11 99.92 Very High Very High Very High
Analgesic 8 99.84 Very High Very High Very High
antidepressant 11 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 471 100.00 Very High Very High Very High
Adhesions 50 100.00 Very High Very High Very High
Rectal Cancer 138 99.92 Very High Very High Very High
Injury 70 99.88 Very High Very High Very High
Necrosis 31 99.84 Very High Very High Very High
Experimental Autoimmune Neuritis 8 99.84 Very High Very High Very High
Periodontitis 60 99.80 Very High Very High Very High
Pressure And Volume Under Development 10 99.76 Very High Very High Very High
Neuropathic Pain 97 99.72 Very High Very High Very High
Cancer 94 99.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated expression and activation of NF-kappaB in experimental autoimmune neuritis (EAN) in rat sciatic nerves removed after 7, 14 and 21 days after immunization.
Gene_expression (expression) of NF-kappaB in sciatic nerves associated with experimental autoimmune neuritis, immunization, sciatic nerve and neuritis
1) Confidence 0.78 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16516982 Disease Relevance 0.53 Pain Relevance 0.48
We examined NF-kappaB expression in rat TMJs with synovitis induced by condyle hypermobility.
Spec (examined) Gene_expression (expression) of NF-kappaB in condyle associated with synovitis
2) Confidence 0.78 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12598546 Disease Relevance 0.65 Pain Relevance 0.29
Southwestern histochemistry, a new method for detecting transcription factors, showed greater NF-kappaB expression in the nucleus of the synovial lining cells in the hypertrophic synovium than in control synovium.
Gene_expression (expression) of NF-kappaB in lining cells
3) Confidence 0.78 Published 2003 Journal J. Dent. Res. Section Abstract Doc Link 12598546 Disease Relevance 0.66 Pain Relevance 0.41
[Expression of NF-kappaB and TNF-alpha in spinal dorsal horn in a rat model of neuropathic pain].
Gene_expression (Expression) of NF-kappaB in spinal associated with neuralgia, spinal dorsal horn and neuropathic pain
4) Confidence 0.77 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Title Doc Link 20646530 Disease Relevance 0.10 Pain Relevance 0.49
OBJECTIVE: To investigate the expressions of NF-kappaB and TNF-alpha in lumbar spinal cord in a rat model of chronic constrictive injury (CCI).
Spec (investigate) Gene_expression (expressions) of NF-kappaB in spinal cord associated with injury and spinal cord
5) Confidence 0.77 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 20646530 Disease Relevance 0.17 Pain Relevance 0.16
As compared with contralateral side and sham group, the expressions of NF-kappaB and TNF-alpha mRNA increased significantly in ipsilateral spinal dorsal horn.
Gene_expression (expressions) of NF-kappaB in spinal
6) Confidence 0.77 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646530 Disease Relevance 0.06 Pain Relevance 0
The expressions of NF-kappaB and TNF-alpha in spinal cord were examined by real-time PCR and double-immunofluorescence histochemical technique.
Spec (examined) Gene_expression (expressions) of NF-kappaB in spinal cord
7) Confidence 0.77 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646530 Disease Relevance 0.07 Pain Relevance 0
RESULTS: CCI induced mechanical allodynia and thermal hyperalgesia and significantly increased NF-kappaB p65 protein expression.
Gene_expression (expression) of NF-kappaB
8) Confidence 0.77 Published 2006 Journal Br J Anaesth Section Body Doc Link 16885169 Disease Relevance 0.23 Pain Relevance 0
Intrathecal injection of antisense ODN markedly suppressed the expression of NF-kappaB p65 protein and significantly attenuated CCI-induced mechanical allodynia and thermal hyperalgesia.
Gene_expression (expression) of NF-kappaB
9) Confidence 0.77 Published 2006 Journal Br J Anaesth Section Body Doc Link 16885169 Disease Relevance 0.21 Pain Relevance 0
The inflammatory cytokines production such as TNFalpha, IL-1beta, IL-10 and nuclear factor kappa B (NF-kappaB) activity in brain was quantified using enzyme-linked immunosorbent assay (ELISA) and electrophoretic mobility shift assay (EMSA).
Gene_expression (production) of NF-kappaB in brain associated with inflammation and cytokine
10) Confidence 0.74 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18248895 Disease Relevance 0.81 Pain Relevance 1.10
RESULTS: After i.p. injection of LPS, the expression of NF-kappaB in the nuclear extracts was significantly increased and I kappaB alpha in the cytosol extracts was markedly decreased.
Gene_expression (expression) of NF-kappaB
11) Confidence 0.74 Published 2008 Journal Pharmacology Section Body Doc Link 17785997 Disease Relevance 0.07 Pain Relevance 0
To investigate the activation of NF-kappaB, the expression of NF-kappaB in the nuclear and I kappaB alpha in the cytosol extracts were analyzed by Western blot.
Gene_expression (expression) of NF-kappaB
12) Confidence 0.74 Published 2008 Journal Pharmacology Section Body Doc Link 17785997 Disease Relevance 0.08 Pain Relevance 0
NF-kappaB DNA-binding activity was analyzed by electromobility shift assay, and changes in the expression of the p50 NF-kappaB subunit and the proinflammatory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) were detected by immunohistochemistry.
Gene_expression (expression) of NF-kappaB
13) Confidence 0.73 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506183 Disease Relevance 0.08 Pain Relevance 0
Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy.
Gene_expression (expressions) of NF-kappaB associated with pain, neuropathic pain and cytokine
14) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 16501235 Disease Relevance 0.76 Pain Relevance 0.84
The effects of topical betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines were studied in a rat model of L5 spinal nerve transaction.
Gene_expression (expression) of NF-kappaB in spinal nerve associated with neuropathic pain and cytokine
15) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.61 Pain Relevance 0.56
The objective of this study was to investigate whether corticosteroids modulate neuropathic pain by altering cerebral expression of nuclear factor-kappa B (NF-kappaB) and specific cytokines.
Gene_expression (expression) of NF-kappaB associated with corticosteroid, neuropathic pain and cytokine
16) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.47 Pain Relevance 0.45
Betamethasone may act by regulating the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Gene_expression (expression) of NF-kappaB in brain
17) Confidence 0.72 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.84 Pain Relevance 0.85
Effect of betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines.
Gene_expression (expression) of NF-kappaB associated with neuropathic pain and cytokine
18) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16253423 Disease Relevance 0.98 Pain Relevance 1.26
Cerebral expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 was quantified using electrophoretic mobility shift assay (EMSA) or enzyme-linked immunosorbent assay (ELISA).
Gene_expression (expression) of NF-kappaB
19) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16253423 Disease Relevance 1.08 Pain Relevance 1.06
We found that spinal nerve injury caused long-lasting mechanical and thermal hyperalgesia in the hind paw and stimulated the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Gene_expression (expression) of NF-kappaB in spinal nerve associated with nervous system injury and thermal hyperalgesia
20) Confidence 0.70 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16253423 Disease Relevance 1.41 Pain Relevance 1.22

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