INT81531

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 27
Total Number 29
Disease Relevance 13.90
Pain Relevance 11.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
blood 4
spinal nerve 2
nucleus 2
intestine 2
spinal 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 107 100.00 Very High Very High Very High
Inflammatory response 25 100.00 Very High Very High Very High
antidepressant 10 100.00 Very High Very High Very High
Inflammatory mediators 7 100.00 Very High Very High Very High
Inflammation 160 99.92 Very High Very High Very High
ketamine 4 99.76 Very High Very High Very High
tricyclic antidepressant 2 99.76 Very High Very High Very High
aspirin 7 99.64 Very High Very High Very High
Endep 6 99.60 Very High Very High Very High
Thermal hyperalgesia 3 99.58 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 188 100.00 Very High Very High Very High
Adhesions 23 100.00 Very High Very High Very High
Periodontitis 60 99.98 Very High Very High Very High
Death 12 99.98 Very High Very High Very High
Pneumonia 4 99.92 Very High Very High Very High
Experimental Autoimmune Neuritis 5 99.84 Very High Very High Very High
Hyperalgesia 18 99.58 Very High Very High Very High
Pancreatic Cancer 7 99.56 Very High Very High Very High
Breast Cancer 3 99.48 Very High Very High Very High
Peripheral Neuropathy 1 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: CCI induced mechanical allodynia and thermal hyperalgesia and significantly increased NF-kappaB p65 protein expression.
Positive_regulation (increased) of Gene_expression (expression) of NF-kappaB
1) Confidence 0.69 Published 2006 Journal Br J Anaesth Section Body Doc Link 16885169 Disease Relevance 0.23 Pain Relevance 0
RESULTS: After i.p. injection of LPS, the expression of NF-kappaB in the nuclear extracts was significantly increased and I kappaB alpha in the cytosol extracts was markedly decreased.
Positive_regulation (increased) of Gene_expression (expression) of NF-kappaB
2) Confidence 0.66 Published 2008 Journal Pharmacology Section Body Doc Link 17785997 Disease Relevance 0.07 Pain Relevance 0
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Positive_regulation (mediated) of Gene_expression (expression) of NF-kappaB associated with aspirin, dexamethasone and cytokine
3) Confidence 0.57 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.68
We investigated expression and activation of NF-kappaB in experimental autoimmune neuritis (EAN) in rat sciatic nerves removed after 7, 14 and 21 days after immunization.
Spec (investigated) Positive_regulation (activation) of Gene_expression (expression) of NF-kappaB in sciatic nerves associated with experimental autoimmune neuritis, immunization, sciatic nerve and neuritis
4) Confidence 0.50 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16516982 Disease Relevance 0.53 Pain Relevance 0.48
A significant increase in nuclear content of p65, an indicator of NF-kappaB activation, was detected in trigeminal nucleus caudalis in rats following injection with nitroglycerin.
Positive_regulation (increase) of Gene_expression (activation) of NF-kappaB in nucleus
5) Confidence 0.50 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19733216 Disease Relevance 0.34 Pain Relevance 0.33
As compared with contralateral side and sham group, the expressions of NF-kappaB and TNF-alpha mRNA increased significantly in ipsilateral spinal dorsal horn.
Positive_regulation (increased) of Gene_expression (expressions) of NF-kappaB in spinal
6) Confidence 0.50 Published 2010 Journal Zhonghua Yi Xue Za Zhi Section Body Doc Link 20646530 Disease Relevance 0.06 Pain Relevance 0
Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-kappaB activation, and overexpression of tubulointerstitial angiotensin II.
Positive_regulation (overexpression) of Gene_expression (overexpression) of NF-kappaB in immune cells associated with inflammation
7) Confidence 0.48 Published 2005 Journal Antioxid. Redox Signal. Section Title Doc Link 16115032 Disease Relevance 0.33 Pain Relevance 0.19
In addition, periodontitis caused a significant increase in the NF-kB p65 levels in the nuclear fractions from of gingivomucosal tissues from operated rats (Figure 3b, b1) compared to the of gingivomucosal tissues from the contralateral side (Figure 3b, b1).
Positive_regulation (increase) of Gene_expression (levels) of NF-kB associated with periodontitis
8) Confidence 0.47 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.43 Pain Relevance 0
Expression of NF-kappaB and its mRNA and intercellular adhesion molecule-1 mRNA was significantly increased in the CAO group compared with the sham group and was significantly decreased in the T + CAO animals.
Positive_regulation (increased) of Gene_expression (Expression) of NF-kappaB
9) Confidence 0.46 Published 2009 Journal Eur J Anaesthesiol Section Body Doc Link 19829116 Disease Relevance 0.05 Pain Relevance 0
We found that spinal nerve injury caused long-lasting mechanical and thermal hyperalgesia in the hind paw and stimulated the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Positive_regulation (stimulated) of Gene_expression (expression) of NF-kappaB in spinal nerve associated with nervous system injury and thermal hyperalgesia
10) Confidence 0.45 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16253423 Disease Relevance 1.41 Pain Relevance 1.22
Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes.
Positive_regulation (induced) of Gene_expression (production) of NF-kappaB in astrocytes associated with diclofenac and cytokine
11) Confidence 0.43 Published 2009 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 19393675 Disease Relevance 0.70 Pain Relevance 0.46
Ketamine suppresses endotoxin-induced NF-kappaB activation and cytokines production in the intestine.
Positive_regulation (endotoxin-induced) of Gene_expression (production) of NF-kappaB in intestine associated with ketamine and cytokine
12) Confidence 0.41 Published 2004 Journal Acta Anaesthesiol Scand Section Title Doc Link 14982564 Disease Relevance 0.27 Pain Relevance 0.38
The activation of NF-kappaB might trigger a cascade of pathophysiological processes to occur: 1) The expression of NF-kappaB-related inflammatory mediators would be increased to exert their inflammatory component in the model of neuropathic pain; 2) Among the inflammatory mediators expressed, tumor necrosis factor-alpha (TNF-?)
Positive_regulation (increased) of Gene_expression (expression) of NF-kappaB-related associated with necrosis, inflammatory mediators, inflammation, cancer and neuropathic pain
13) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.14 Pain Relevance 1.06
Blueberry and piroxicam supplementations were found to attenuate the kainic acid-induced increase in the expression of IL-1beta, TNF-alpha, and NF-kappaB, while only blueberry was able to augment the increased IGF-1 expression.
Positive_regulation (increase) of Gene_expression (expression) of NF-kappaB
14) Confidence 0.37 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.54 Pain Relevance 0.44
Hypericum treatment significantly prevented the periodontitis-mediated NF-kB p65 expression (Figure 3b, b1).
Positive_regulation (mediated) of Gene_expression (expression) of NF-kB associated with periodontitis
15) Confidence 0.34 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.34 Pain Relevance 0
A relatively small number of inducible transcription factors, particularly NF-kappaB, AP-1, NFATs and STATs, are responsible for the expression of a wide variety of inflammatory phenotypic characteristics and therefore play a central role in the pathogenesis of rheumatic diseases.
Positive_regulation (responsible) of Gene_expression (expression) of NF-kappaB associated with inflammation and rheumatic diseases
16) Confidence 0.32 Published 2001 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 11812014 Disease Relevance 0.46 Pain Relevance 0.23
Cells were transiently transfected with a NF-kappaB reporter gene and changes in luciferase activity were detected by bioluminescence.
Positive_regulation (transfected) of Gene_expression (transfected) of NF-kappaB
17) Confidence 0.32 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14501032 Disease Relevance 0 Pain Relevance 0.73
The activation of NF-kappaB might trigger a cascade of pathophysiological processes to occur: 1) The expression of NF-kappaB-related inflammatory mediators would be increased to exert their inflammatory component in the model of neuropathic pain; 2) Among the inflammatory mediators expressed, tumor necrosis factor-alpha (TNF-?)
Positive_regulation (mediators) of Gene_expression (expression) of NF-kappaB-related associated with necrosis, inflammatory mediators, inflammation, cancer and neuropathic pain
18) Confidence 0.29 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.13 Pain Relevance 1.06
The endotoxemia that occurs after strenuous exercise results in increased circulating LPS and may be another mechanism underlying the elevation in TLR-4 and NF-kBp65 protein expression [21].
Positive_regulation (elevation) of Gene_expression (expression) of NF-kBp65 associated with endotoxemia
19) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.50 Pain Relevance 0.12
Taken together, our results suggest that the increase in cytokine concentration and augmented TLR-4 and NF-kBp65 protein expression induced by overtraining in the epidydymal adipose tissue may lead to a shift toward increased inflammation.
Positive_regulation (augmented) of Gene_expression (expression) of NF-kBp65 in adipose tissue associated with inflammation, obesity and cytokine
20) Confidence 0.27 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.78 Pain Relevance 0.18

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