INT81532

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Context Info
Confidence 0.54
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 21
Total Number 21
Disease Relevance 8.92
Pain Relevance 7.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
endothelial cells 5
nucleus 4
astrocytes 2
mast cells 2
leukocytes 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 48 100.00 Very High Very High Very High
COX2 4 100.00 Very High Very High Very High
cytokine 17 98.44 Very High Very High Very High
Inflammation 49 98.22 Very High Very High Very High
dexamethasone 8 96.56 Very High Very High Very High
cINOD 18 96.36 Very High Very High Very High
Migraine 7 96.08 Very High Very High Very High
diclofenac 2 95.04 Very High Very High Very High
Analgesic 14 94.72 High High
Central nervous system 6 89.44 High High
Disease Link Frequency Relevance Heat
Stomach Cancer 3 98.64 Very High Very High Very High
INFLAMMATION 56 98.22 Very High Very High Very High
Headache 7 96.08 Very High Very High Very High
Nociception 4 94.40 High High
Myocardial Infarction 4 91.76 High High
Adhesions 12 89.84 High High
Pressure And Volume Under Development 3 87.36 High High
Demyelinating Disease 4 86.84 High High
Injury 6 85.48 High High
Necrosis 8 83.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.
Negative_regulation (inhibits) of Protein_catabolism (degradation) of IkBalpha
1) Confidence 0.54 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12417429 Disease Relevance 0.34 Pain Relevance 0.30
The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of IkappaBalpha associated with aspirin
2) Confidence 0.44 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.56 Pain Relevance 0.58
Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.
Negative_regulation (inhibits) of Protein_catabolism (degradation) of IkappaBalpha
3) Confidence 0.34 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12417429 Disease Relevance 0.34 Pain Relevance 0.30
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (blocking) of Protein_catabolism (degradation) of kappa B-alpha in nucleus
4) Confidence 0.10 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.66 Pain Relevance 0.23
We observed that pretreatment of endothelial cells with piperine blocks the nuclear translocation and activation of NF-kappaB via blocking the phosphorylation and degradation of its inhibitory protein, IkappaBalpha.
Negative_regulation (blocking) of Protein_catabolism (degradation) of IkappaBalpha in endothelial cells
5) Confidence 0.08 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.73 Pain Relevance 0.20
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (blocking) of Protein_catabolism (degradation) of kappa B-alpha in nucleus
6) Confidence 0.07 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.66 Pain Relevance 0.23
NF-kappaB is activated by IkappaBalpha, its inhibitor, which is phosphorylated and proteolytically degraded.
Negative_regulation (inhibitor) of Protein_catabolism (degraded) of IkappaBalpha
7) Confidence 0.07 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790762 Disease Relevance 0.10 Pain Relevance 0.46
NF-kappaB is activated by IkappaBalpha, its inhibitor, which is phosphorylated and proteolytically degraded.
Negative_regulation (inhibitor) of Protein_catabolism (degraded) of IkappaBalpha
8) Confidence 0.07 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790762 Disease Relevance 0.10 Pain Relevance 0.46
Our results indicate that CPDHC inhibits the NF-kappaB pathway by preventing the phosphorylation and proteolytic degradation of the IkappaBalpha protein.
Negative_regulation (preventing) of Protein_catabolism (degradation) of IkappaBalpha
9) Confidence 0.06 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.07 Pain Relevance 0.09
Piperine blocks the phosphorylation and degradation of IkappaBalpha by attenuating TNF-alpha induced IkappaB kinase activity.
Negative_regulation (blocks) of Protein_catabolism (degradation) of IkappaBalpha
10) Confidence 0.06 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.70 Pain Relevance 0.20
All drugs inhibited IkappaBalpha kinase and suppressed IkappaBalpha degradation and NF-kappaB-regulated reporter gene expression.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of IkappaBalpha
11) Confidence 0.06 Published 2004 Journal Oncogene Section Abstract Doc Link 15489888 Disease Relevance 0.57 Pain Relevance 0.67
IkappaBalpha degradation, NF-kappaB activation, and iNOS expression were attenuated by parthenolide (3mg/kg), the active constituent of feverfew, an anti-inflammatory drug used for migraine treatment.
Negative_regulation (attenuated) of Protein_catabolism (degradation) of IkappaBalpha associated with inflammation and migraine
12) Confidence 0.05 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.71 Pain Relevance 0.58
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Negative_regulation (decreased) of Protein_catabolism (degradation) of IkappaB-alpha associated with aspirin, dexamethasone and cytokine
13) Confidence 0.04 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.71
Western blot analyses showed that both L-lactic acid and LcS culture supernatants suppressed phosphorylation and degradation of I-kappaB-alpha induced by LPS without affecting expression of TLR4.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of I-kappaB-alpha
14) Confidence 0.02 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19589943 Disease Relevance 0.77 Pain Relevance 0.03
We show that inhibition of NF-kappaB activation by tepoxalin is mediated by preventing IkappaB-alpha degradation.
Negative_regulation (preventing) of Protein_catabolism (degradation) of IkappaB-alpha
15) Confidence 0.02 Published 1999 Journal Neuropharmacology Section Abstract Doc Link 10471086 Disease Relevance 0.40 Pain Relevance 0.39
The non-steroidal anti-inflammatory drug tepoxalin inhibits interleukin-6 and alpha1-anti-chymotrypsin synthesis in astrocytes by preventing degradation of IkappaB-alpha.
Negative_regulation (preventing) of Protein_catabolism (degradation) of IkappaB-alpha in astrocytes associated with inflammation
16) Confidence 0.02 Published 1999 Journal Neuropharmacology Section Title Doc Link 10471086 Disease Relevance 0.51 Pain Relevance 0.42
Consistently gamma-mangostin was also observed to decrease the LPS-induced IkappaB degradation and phosphorylation in a concentration-dependent manner, as assayed by immunoblotting.
Negative_regulation (decrease) of Protein_catabolism (degradation) of IkappaB
17) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.20 Pain Relevance 0.06
We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkappaB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkappaB-alpha, activation of NF-kappaB, and transcription of proinflammatory cytokines.
Negative_regulation (inhibiting) of Protein_catabolism (degradation) of IkappaB-alpha in mast cells associated with aspirin, inflammation and cytokine
18) Confidence 0.01 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763541 Disease Relevance 0.48 Pain Relevance 0.67
Acetylsalicylic acid (ASA) blocks NF-kappaB-dependent gene activation in leukocytes and endothelial cells through preventing phosphorylation and subsequent degradation of the inhibitor IkappaB-alpha.
Negative_regulation (preventing) of Protein_catabolism (degradation) of IkappaB-alpha in endothelial cells associated with aspirin
19) Confidence 0.00 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16116334 Disease Relevance 0.30 Pain Relevance 0.25
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Negative_regulation (Suppression) of Protein_catabolism (degradation) of IkappaB-alpha associated with aspirin and stomach cancer
20) Confidence 0.00 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.43 Pain Relevance 0.31

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