INT81535

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.44
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 5.74
Pain Relevance 5.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
endothelial cells 7
mast cells 2
leukocytes 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 46 99.42 Very High Very High Very High
cytokine 17 98.44 Very High Very High Very High
Inflammation 31 98.22 Very High Very High Very High
cINOD 21 98.16 Very High Very High Very High
dexamethasone 5 96.22 Very High Very High Very High
pain pelvic 1 77.84 Quite High
endometriosis 2 77.08 Quite High
opiate 2 75.00 Quite High
Morphine 2 73.52 Quite High
Opioid 1 72.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 38 98.22 Very High Very High Very High
Adhesions 18 92.44 High High
Myocardial Infarction 4 91.76 High High
Injury 6 85.48 High High
Necrosis 7 84.96 Quite High
Cancer 7 84.60 Quite High
Endometriosis 4 83.48 Quite High
Coronary Heart Disease 2 79.60 Quite High
Reprotox - General 3 2 78.48 Quite High
Sprains And Strains 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of IkappaBalpha associated with aspirin
1) Confidence 0.44 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.56 Pain Relevance 0.58
In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and IkappaBalpha, as well as the nuclear translocation of NF-kappaB primed by LPS.
Negative_regulation (attenuated) of Phosphorylation (phosphorylation) of IkappaBalpha
2) Confidence 0.30 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.31 Pain Relevance 0.19
Piperine blocks the phosphorylation and degradation of IkappaBalpha by attenuating TNF-alpha induced IkappaB kinase activity.
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of IkappaBalpha
3) Confidence 0.08 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.70 Pain Relevance 0.20
We observed that pretreatment of endothelial cells with piperine blocks the nuclear translocation and activation of NF-kappaB via blocking the phosphorylation and degradation of its inhibitory protein, IkappaBalpha.
Negative_regulation (blocks) of Phosphorylation (phosphorylation) of IkappaBalpha in endothelial cells
4) Confidence 0.08 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.75 Pain Relevance 0.20
NF-kappaB is activated by IkappaBalpha, its inhibitor, which is phosphorylated and proteolytically degraded.
Negative_regulation (inhibitor) of Phosphorylation (phosphorylated) of IkappaBalpha
5) Confidence 0.07 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790762 Disease Relevance 0.10 Pain Relevance 0.45
Our results indicate that CPDHC inhibits the NF-kappaB pathway by preventing the phosphorylation and proteolytic degradation of the IkappaBalpha protein.
Negative_regulation (preventing) of Phosphorylation (phosphorylation) of IkappaBalpha
6) Confidence 0.06 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.07 Pain Relevance 0.09
We observed that pretreatment of endothelial cells with piperine blocks the nuclear translocation and activation of NF-kappaB via blocking the phosphorylation and degradation of its inhibitory protein, IkappaBalpha.
Negative_regulation (blocking) of Phosphorylation (phosphorylation) of IkappaBalpha in endothelial cells
7) Confidence 0.06 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.73 Pain Relevance 0.20
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of IkappaB-alpha associated with aspirin, dexamethasone and cytokine
8) Confidence 0.05 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.71
NSAIDs inhibited the activity of purified RSK2 kinase in vitro and of RSK2 in mammalian cells and suppressed the phosphorylation of RSK2 substrates cAMP response element binding protein (CREB) and I-kappa B alpha in vivo.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of I-kappa B alpha associated with cinod
9) Confidence 0.04 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10553090 Disease Relevance 0.14 Pain Relevance 0.60
By transfection of TAK1 siRNA, TNFalpha-induced phosphorylation of IkappaBalpha, JNK1/2, and p38MAPK, as well as IL-6 or IL-8 expression, were repressed.
Negative_regulation (repressed) of Phosphorylation (phosphorylation) of IkappaBalpha
10) Confidence 0.04 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 19410630 Disease Relevance 0.39 Pain Relevance 0.19
Additionally, NaSal inhibited the phosphorylation by RSK2 of CREB and I-kappa B alpha on residues crucial for their transcriptional activity in vivo and thus repressed CREB and NF-kappa B-dependent transcription.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of I-kappa B alpha
11) Confidence 0.04 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10553090 Disease Relevance 0.13 Pain Relevance 0.58
Western blot analyses showed that both L-lactic acid and LcS culture supernatants suppressed phosphorylation and degradation of I-kappaB-alpha induced by LPS without affecting expression of TLR4.
Negative_regulation (suppressed) of Phosphorylation (phosphorylation) of I-kappaB-alpha
12) Confidence 0.02 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19589943 Disease Relevance 0.77 Pain Relevance 0.03
We thus propose that the anti-inflammatory effects of ASA in mast cells are due to suppression of IkappaB kinase activity, thereby inhibiting subsequent phosphorylation and degradation of IkappaB-alpha, activation of NF-kappaB, and transcription of proinflammatory cytokines.
Negative_regulation (inhibiting) of Phosphorylation (phosphorylation) of IkappaB-alpha in mast cells associated with aspirin, inflammation and cytokine
13) Confidence 0.01 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763541 Disease Relevance 0.48 Pain Relevance 0.67
Acetylsalicylic acid (ASA) blocks NF-kappaB-dependent gene activation in leukocytes and endothelial cells through preventing phosphorylation and subsequent degradation of the inhibitor IkappaB-alpha.
Negative_regulation (preventing) of Phosphorylation (phosphorylation) of IkappaB-alpha in endothelial cells associated with aspirin
14) Confidence 0.00 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16116334 Disease Relevance 0.30 Pain Relevance 0.25
Acetylsalicylic acid (ASA) blocks NF-kappaB-dependent gene activation in leukocytes and endothelial cells through preventing phosphorylation and subsequent degradation of the inhibitor IkappaB-alpha.
Negative_regulation (preventing) of in leukocytes Phosphorylation (phosphorylation) of IkappaB-alpha in endothelial cells associated with aspirin
15) Confidence 0.00 Published 2005 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16116334 Disease Relevance 0.30 Pain Relevance 0.25

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox