INT81537

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 10
Total Number 13
Disease Relevance 7.09
Pain Relevance 7.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nfkb1) DNA binding (Nfkb1) protein complex (Nfkb1)
cytoplasm (Nfkb1) cytosol (Nfkb1) signal transduction (Nfkb1)
Anatomy Link Frequency
spinal nerve 2
brain 2
PBMC 2
Nfkb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 66 100.00 Very High Very High Very High
cytokine 38 100.00 Very High Very High Very High
Pain 34 100.00 Very High Very High Very High
Neuropathic pain 20 100.00 Very High Very High Very High
ketamine 7 100.00 Very High Very High Very High
Analgesic 4 99.84 Very High Very High Very High
aspirin 7 99.64 Very High Very High Very High
corticosteroid 8 99.40 Very High Very High Very High
Hippocampus 4 98.16 Very High Very High Very High
Freund adjuvant 8 98.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 100.00 Very High Very High Very High
Neuropathic Pain 30 100.00 Very High Very High Very High
Periodontitis 30 100.00 Very High Very High Very High
Adhesions 7 100.00 Very High Very High Very High
Necrosis 7 99.12 Very High Very High Very High
Endotoxemia 1 98.96 Very High Very High Very High
Cancer 7 98.94 Very High Very High Very High
Apoptosis 8 98.72 Very High Very High Very High
Pain 20 98.60 Very High Very High Very High
Hyperalgesia 14 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of topical betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines were studied in a rat model of L5 spinal nerve transaction.
Regulation (effects) of Gene_expression (expression) of NF-kappaB in spinal nerve associated with neuropathic pain and cytokine
1) Confidence 0.57 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.61 Pain Relevance 0.57
Betamethasone affects cerebral expressions of NF-kappaB and cytokines that correlate with pain behavior in a rat model of neuropathy.
Regulation (affects) of Gene_expression (expressions) of NF-kappaB associated with pain, neuropathic pain and cytokine
2) Confidence 0.57 Published 2006 Journal Ann. Clin. Lab. Sci. Section Title Doc Link 16501235 Disease Relevance 0.76 Pain Relevance 0.84
Effect of betamethasone on neuropathic pain and cerebral expression of NF-kappaB and cytokines.
Regulation (Effect) of Gene_expression (expression) of NF-kappaB associated with neuropathic pain and cytokine
3) Confidence 0.56 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16253423 Disease Relevance 0.98 Pain Relevance 1.26
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Neg (without) Regulation (affecting) of Gene_expression (expression) of NF-kappaB associated with aspirin, dexamethasone and cytokine
4) Confidence 0.51 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.69
Betamethasone may act by regulating the expression of NF-kappaB, TNFalpha, IL-1beta and IL-10 in the brain.
Regulation (regulating) of Gene_expression (expression) of NF-kappaB in brain
5) Confidence 0.42 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.84 Pain Relevance 0.88
Hypericum treatment significantly prevented the periodontitis-mediated NF-kB p65 expression (Figure 3b, b1).
Regulation (periodontitis) of Gene_expression (expression) of NF-kB associated with periodontitis
6) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.39 Pain Relevance 0
Kainic acid up-regulated the expression of the inflammatory cytokines IL-1beta and TNF-alpha, the neurotrophic factor IGF-1, and the transcription factor NF-kappaB.
Regulation (regulated) of Gene_expression (expression) of NF-kappaB associated with inflammation and cytokine
7) Confidence 0.29 Published 2008 Journal Nutr Neurosci Section Abstract Doc Link 18681986 Disease Relevance 0.70 Pain Relevance 0.53
In this paper, we attempted to investigate whether the transcription factors regulating the gene expression of c-fos and nNOS, including activator protein-1 (AP-1), nuclear factor kappa B (NF-kappa B), and octamer factors (Oct), are activated by CFA during the development of hyperalgesia.
Spec (whether) Regulation (regulating) of Gene_expression (expression) of NF-kappa B associated with hyperalgesia and freund adjuvant
8) Confidence 0.27 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940358 Disease Relevance 0.27 Pain Relevance 0.60
NF-kappaB DNA-binding activity was analyzed by electromobility shift assay, and changes in the expression of the p50 NF-kappaB subunit and the proinflammatory neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) were detected by immunohistochemistry.
Regulation (changes) of Gene_expression (expression) of NF-kappaB
9) Confidence 0.25 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506183 Disease Relevance 0.09 Pain Relevance 0
The objective of this study was to investigate whether corticosteroids modulate neuropathic pain by altering cerebral expression of nuclear factor-kappa B (NF-kappaB) and specific cytokines.
Spec (whether) Regulation (altering) of Gene_expression (expression) of NF-kappaB associated with corticosteroid, neuropathic pain and cytokine
10) Confidence 0.25 Published 2006 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 16501235 Disease Relevance 0.47 Pain Relevance 0.45
The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?
Regulation (source) of Gene_expression (pathway) of NF-kappaB associated with pain and analgesic
11) Confidence 0.16 Published 2008 Journal FASEB J. Section Title Doc Link 18559989 Disease Relevance 0.96 Pain Relevance 1.01
This study examined the effect of ketamine on NFkappaB activation and TNFalpha production in rat peripheral blood mononuclear cells (PBMC).
Spec (examined) Regulation (effect) of Gene_expression (production) of NFkappaB in PBMC associated with ketamine
12) Confidence 0.14 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 12175093 Disease Relevance 0.18 Pain Relevance 0.35
A triple function of PLA2-derived lipid mediators has been suggested: causing immediate inflammatory signs, involvement in secondary processes, e.g., superoxide free radical (O2) generation, apoptosis, or tumour necrosis factor-alpha (TNF-alpha)-cytotoxicity, and controlling the expression and activation of pivotal proteins implicated in inflammation and cell development, e.g., cytokines, adhesion proteins, proteinases, NF-kappaB, fos/jun/AP-1, c-Myc, or p21ras.
Regulation (controlling) of Gene_expression (expression) of NF-kappaB associated with necrosis, inflammation, cancer, apoptosis, adhesions and cytokine
13) Confidence 0.02 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15989628 Disease Relevance 0.84 Pain Relevance 0.31

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