INT81538

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Context Info
Confidence 0.62
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 27
Total Number 27
Disease Relevance 8.86
Pain Relevance 10.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
endothelial cells 2
leukocytes 1
spleen 1
nucleus 1
mast cells 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 16 99.54 Very High Very High Very High
aspirin 80 99.42 Very High Very High Very High
Endep 11 99.36 Very High Very High Very High
cytokine 43 98.44 Very High Very High Very High
Inflammation 55 98.08 Very High Very High Very High
cINOD 34 97.86 Very High Very High Very High
dexamethasone 20 96.02 Very High Very High Very High
Inflammatory response 5 94.20 High High
intrathecal 4 93.68 High High
Antinociceptive 2 89.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 70 98.08 Very High Very High Very High
Stomach Cancer 3 93.32 High High
Stress 2 93.04 High High
Necrosis 13 91.80 High High
Myocardial Infarction 4 91.76 High High
Cancer 15 91.44 High High
Adhesions 12 89.32 High High
Injury 9 85.04 High High
Endometriosis 4 83.48 Quite High
Infection 1 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data also showed that NF-kappaB activation and its associated gene expressions, such as COX-2, iNOS, VCAM-1 and ICAM-1, were all suppressed by the low dose aspirin supplementation through the inhibition of phosphorylation and degradation of IkappaBalpha via the NIK/IKK pathway.
Phosphorylation (phosphorylation) of IkappaBalpha associated with aspirin
1) Confidence 0.62 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16310244 Disease Relevance 0.56 Pain Relevance 0.58
Moreover, amitriptyline/morphine co-infusion increased IkappaBalpha phosphorylation and the translocation of NF-kappaB p65 from the cytosol to the nucleus.
Phosphorylation (phosphorylation) of IkappaBalpha in nucleus associated with endep and morphine
2) Confidence 0.61 Published 2008 Journal Neuroscience Section Abstract Doc Link 18400403 Disease Relevance 0 Pain Relevance 1.83
In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and IkappaBalpha, as well as the nuclear translocation of NF-kappaB primed by LPS.
Phosphorylation (phosphorylation) of IkappaBalpha
3) Confidence 0.58 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.31 Pain Relevance 0.19
NF-kappaB is activated by IkappaBalpha, its inhibitor, which is phosphorylated and proteolytically degraded.
Phosphorylation (phosphorylated) of IkappaBalpha
4) Confidence 0.14 Published 2000 Journal Med. Hypotheses Section Abstract Doc Link 10790762 Disease Relevance 0.10 Pain Relevance 0.45
We observed that pretreatment of endothelial cells with piperine blocks the nuclear translocation and activation of NF-kappaB via blocking the phosphorylation and degradation of its inhibitory protein, IkappaBalpha.
Phosphorylation (phosphorylation) of IkappaBalpha in endothelial cells
5) Confidence 0.11 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.73 Pain Relevance 0.20
Piperine blocks the phosphorylation and degradation of IkappaBalpha by attenuating TNF-alpha induced IkappaB kinase activity.
Phosphorylation (phosphorylation) of IkappaBalpha
6) Confidence 0.11 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.69 Pain Relevance 0.19
Our results indicate that CPDHC inhibits the NF-kappaB pathway by preventing the phosphorylation and proteolytic degradation of the IkappaBalpha protein.
Phosphorylation (phosphorylation) of IkappaBalpha
7) Confidence 0.08 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11027495 Disease Relevance 0.07 Pain Relevance 0.09
NSAIDs inhibited the activity of purified RSK2 kinase in vitro and of RSK2 in mammalian cells and suppressed the phosphorylation of RSK2 substrates cAMP response element binding protein (CREB) and I-kappa B alpha in vivo.
Phosphorylation (phosphorylation) of I-kappa B alpha associated with cinod
8) Confidence 0.08 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10553090 Disease Relevance 0.14 Pain Relevance 0.59
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Phosphorylation (phosphorylated) of IkappaB-alpha
9) Confidence 0.08 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.18 Pain Relevance 0.69
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Phosphorylation (phosphorylated) of IkappaB-alpha
10) Confidence 0.08 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.37 Pain Relevance 0.70
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Phosphorylation (phosphorylation) of IkappaB-alpha associated with aspirin, dexamethasone and cytokine
11) Confidence 0.08 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.70
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Phosphorylation (phosphorylated) of IkappaB-alpha
12) Confidence 0.07 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.18 Pain Relevance 0.69
By transfection of TAK1 siRNA, TNFalpha-induced phosphorylation of IkappaBalpha, JNK1/2, and p38MAPK, as well as IL-6 or IL-8 expression, were repressed.
Phosphorylation (phosphorylation) of IkappaBalpha
13) Confidence 0.07 Published 2009 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 19410630 Disease Relevance 0.39 Pain Relevance 0.19
Additionally, NaSal inhibited the phosphorylation by RSK2 of CREB and I-kappa B alpha on residues crucial for their transcriptional activity in vivo and thus repressed CREB and NF-kappa B-dependent transcription.
Phosphorylation (phosphorylation) of I-kappa B alpha
14) Confidence 0.07 Published 1999 Journal J. Immunol. Section Abstract Doc Link 10553090 Disease Relevance 0.13 Pain Relevance 0.57
Western blot analyses showed that both L-lactic acid and LcS culture supernatants suppressed phosphorylation and degradation of I-kappaB-alpha induced by LPS without affecting expression of TLR4.
Phosphorylation (phosphorylation) of I-kappaB-alpha
15) Confidence 0.03 Published 2009 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 19589943 Disease Relevance 0.77 Pain Relevance 0.03
Phosphorylation of IkappaB through IkappaB kinase (IKK) is the first step in nuclear factor kappaB (NF-kappaB) activation and upregulation of NF-kappaB-responsive genes.
Phosphorylation (Phosphorylation) of IkappaB
16) Confidence 0.03 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14973242 Disease Relevance 0.62 Pain Relevance 0.26
Although IkappaB inhibitor suppressed the TNF-alpha-induced IL-6 release, the Rho-kinase inhibitors did not affect the TNF-alpha-induced IkappaB phosphorylation.
Phosphorylation (phosphorylation) of IkappaB
17) Confidence 0.02 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19427347 Disease Relevance 0.54 Pain Relevance 0.03
Because LPS is known to stimulate inhibitor kappaB (IkappaB) kinase (IKK)-mediated phosphorylation of IkappaB followed by its degradation, which in turn induces nuclear factor (NF)-kappaB nuclear translocation leading to transcriptional activation of COX-2 gene, the effect of gamma-mangostin on the IKK/IkappaB cascade controlling the NF-kappaB activation was examined.
Phosphorylation (phosphorylation) of IkappaB
18) Confidence 0.02 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.15 Pain Relevance 0
Consistently gamma-mangostin was also observed to decrease the LPS-induced IkappaB degradation and phosphorylation in a concentration-dependent manner, as assayed by immunoblotting.
Phosphorylation (phosphorylation) of IkappaB
19) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.20 Pain Relevance 0.06
Because LPS is known to stimulate inhibitor kappaB (IkappaB) kinase (IKK)-mediated phosphorylation of IkappaB followed by its degradation, which in turn induces nuclear factor (NF)-kappaB nuclear translocation leading to transcriptional activation of COX-2 gene, the effect of gamma-mangostin on the IKK/IkappaB cascade controlling the NF-kappaB activation was examined.
Phosphorylation (phosphorylation) of IkappaB
20) Confidence 0.01 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.15 Pain Relevance 0

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