INT8154

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Context Info
Confidence 0.54
First Reported 1981
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 13
Total Number 14
Disease Relevance 6.59
Pain Relevance 3.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
plasma 4
D cells 2
gastric juice 2
parietal cell 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 59 99.80 Very High Very High Very High
Acupuncture 4 99.28 Very High Very High Very High
gABA 9 96.80 Very High Very High Very High
tetrodotoxin 3 96.80 Very High Very High Very High
Cholecystokinin 10 96.60 Very High Very High Very High
Calcitonin gene-related peptide 13 92.56 High High
peptic ulcer disease 8 88.96 High High
agonist 8 84.56 Quite High
antagonist 4 72.96 Quite High
anesthesia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Achlorhydria 2 99.98 Very High Very High Very High
Duodenal Ulcer 18 99.14 Very High Very High Very High
Gastrinoma 3 97.80 Very High Very High Very High
Hyperplasia 2 93.60 High High
Infection 4 93.08 High High
Ulcers 20 90.96 High High
Duodenitis 3 90.96 High High
Gastritis 5 90.36 High High
Carcinoid 1 89.20 High High
Disease 8 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gastric acid production is mainly controlled by the hormone gastrin through a negative feedback in which hypochlorhydria induces an increase in serum gastrin.
Positive_regulation (induces) of Positive_regulation (increase) of gastrin associated with achlorhydria
1) Confidence 0.54 Published 2008 Journal Rev Prat Section Abstract Doc Link 18924330 Disease Relevance 1.02 Pain Relevance 0.09
Cholinergic mediation of gamma-aminobutyric acid-induced gastrin and somatostatin release from rat antrum.
Positive_regulation (mediation) of Positive_regulation (acid-induced) of gastrin associated with somatostatin
2) Confidence 0.48 Published 1986 Journal Gastroenterology Section Title Doc Link 2875917 Disease Relevance 0 Pain Relevance 0.59
Circumstantial evidence suggests that the abnormal gastrin release could also explain the upregulation of the parietal cell to the acid stimulatory effect and the consequent increase in gastrin sensitivity in patients suffering from duodenal ulcer disease.
Positive_regulation (upregulation) of Positive_regulation (increase) of gastrin in parietal cell associated with duodenal ulcer
3) Confidence 0.46 Published 1991 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 1940201 Disease Relevance 0.93 Pain Relevance 0.12
Field stimulation at 30 V, 10 Hz, 4 ms caused a sixfold increase in gastrin and a twofold increase in somatostatin secretion that were nearly abolished by tetrodotoxin (85-89% inhibition).
Positive_regulation (caused) of Positive_regulation (increase) of gastrin associated with tetrodotoxin and somatostatin
4) Confidence 0.46 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.41
Field stimulation caused an increase in gastrin and somatostatin secretion that was dependent on the strength of the stimulus (10-30 V).
Positive_regulation (caused) of Positive_regulation (increase) of gastrin associated with somatostatin
5) Confidence 0.46 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.35
Eradication of H. pylori decreases IL-1beta induction, resulting in an increase in gastric juice acidity and normalization of serum gastrin levels.
Positive_regulation (resulting) of Positive_regulation (increase) of gastrin in gastric juice
6) Confidence 0.46 Published 1999 Journal J. Gastroenterol. Section Abstract Doc Link 10616759 Disease Relevance 0.46 Pain Relevance 0.07
All three stimuli, i.e. electro-acupuncture, vibration and thermal stimulation caused significant elevations of gastrin (103 +/- 11-151 +/- 16 pM, 105 +/- 8-140 +/- 12 pM and 105 +/- 14-162 +/- 4 pM) and cholecystokinin (9 +/- 0.8-15 +/- 2.8 pM, 8 +/- 0.5-10 +/- 1.5 pM and 8.0 +/- 0.5-10.5 +/- 1.5).
Positive_regulation (caused) of Positive_regulation (elevations) of gastrin associated with acupuncture and cholecystokinin
7) Confidence 0.43 Published 1992 Journal Acta Physiol. Scand. Section Abstract Doc Link 1362318 Disease Relevance 0 Pain Relevance 0.58
The decrease in antral plasma gastrin release was significantly lower after acid instillation and the increase was significantly higher after alkali instillation in duodenal ulcer patients compared with those of controls, indicating an abnormal gastrin response to intragastric pH changes in duodenal ulcer patients, which was again not found to be coupled to any significant difference in antral somatostatin release.
Positive_regulation (abnormal) of Positive_regulation (response) of gastrin in plasma associated with duodenal ulcer and somatostatin
8) Confidence 0.40 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7924733 Disease Relevance 0.43 Pain Relevance 0.24
The decrease in antral plasma gastrin release was significantly lower after acid instillation and the increase was significantly higher after alkali instillation in duodenal ulcer patients compared with those of controls, indicating an abnormal gastrin response to intragastric pH changes in duodenal ulcer patients, which was again not found to be coupled to any significant difference in antral somatostatin release.
Positive_regulation (indicating) of Positive_regulation (response) of gastrin in plasma associated with duodenal ulcer and somatostatin
9) Confidence 0.40 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7924733 Disease Relevance 0.43 Pain Relevance 0.25
The same combination of results, except for negative response to secretin and marked stimulation of gastrin by food, is found in patients with antral gastrin cell hyperfunction.
Positive_regulation (response) of Neg (except) Positive_regulation (stimulation) of gastrin
10) Confidence 0.27 Published 1981 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7320472 Disease Relevance 0.73 Pain Relevance 0.08
The most diagnostic combination of tests comprises markedly increased fasting serum gastrin, positive serum gastrin response to secretin challenge, and increased levels of basal acid secretion and serum pepsinogen I found in patients with gastrinoma.
Positive_regulation (increased) of Positive_regulation (increased) of gastrin associated with gastrinoma
11) Confidence 0.27 Published 1981 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7320472 Disease Relevance 0.63 Pain Relevance 0.09
The most diagnostic combination of tests comprises markedly increased fasting serum gastrin, positive serum gastrin response to secretin challenge, and increased levels of basal acid secretion and serum pepsinogen I found in patients with gastrinoma.
Positive_regulation (increased) of Positive_regulation (response) of gastrin associated with gastrinoma
12) Confidence 0.27 Published 1981 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 7320472 Disease Relevance 0.69 Pain Relevance 0.09
In light of prior known actions of CaSR activation increasing gastrin and acid secretion, the net effect of CaSR ligands may depend on its relative expression in each cell type, whether stimulatory G cells or inhibitory D cells, and whether the endocrine cells are of the closed or open type.
Positive_regulation (increasing) of Positive_regulation (activation) of gastrin in D cells
13) Confidence 0.21 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.16
In the patients with duodenal ulcer, low antral somatostatin concentrations with high antral gastrin/somatostatin ratio may cause increased serum gastrin levels and increased gastric acid secretion.
Spec (may) Positive_regulation (cause) of Positive_regulation (increased) of gastrin associated with duodenal ulcer and somatostatin
14) Confidence 0.16 Published 1981 Journal Peptides Section Abstract Doc Link 6123990 Disease Relevance 0.99 Pain Relevance 0.37

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