INT81540

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Context Info
Confidence 0.22
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.37
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 7 96.80 Very High Very High Very High
cytokine 26 93.20 High High
dexamethasone 5 92.44 High High
Inflammation 26 87.80 High High
cINOD 6 66.76 Quite High
Inflammatory response 9 30.84 Quite Low
COX2 2 25.00 Low Low
Central nervous system 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 3 94.96 High High
Lung Injury 13 89.72 High High
Cancer 5 89.04 High High
Necrosis 5 88.56 High High
INFLAMMATION 37 87.80 High High
Neuroblastoma 3 75.00 Quite High
Reprotox - General 1 1 75.00 Quite High
Repression 2 68.04 Quite High
Stress 7 60.24 Quite High
Immune System Diseases 1 57.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
 : inhibitory kappa B alpha; IL-6: interleukin-6; MV: mechanical ventilation; NF-?
Positive_regulation (ventilation) of inhibitory kappa B alpha
1) Confidence 0.22 Published 2010 Journal Respir Res Section Body Doc Link PMC2841148 Disease Relevance 0.71 Pain Relevance 0.22
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Positive_regulation (increase) of IkappaB-alpha
2) Confidence 0.06 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.38 Pain Relevance 0.71
We verified gene induction by omega-6 fatty acid, including COX-2, IkappaBalpha, NF-kappaB, GM-CSF, IL-1beta, CXCL-1, TNF-alpha, IL-6, LTA, IL-8, PPARgamma, and ICAM-1, using quantitative reverse transcription-PCR.
Positive_regulation (induction) of IkappaBalpha
3) Confidence 0.04 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16452198 Disease Relevance 0.14 Pain Relevance 0
Based on RT-PCR, mefloquine upregulated cJun, IkappaB and GADD153.
Positive_regulation (upregulated) of IkappaB
4) Confidence 0.02 Published 2003 Journal Malar J Section Abstract Doc Link PMC152658 Disease Relevance 0.15 Pain Relevance 0

General Comments

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