INT81541

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Context Info
Confidence 0.51
First Reported 1999
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 5.73
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Anatomy Link Frequency
endothelial cells 1
spleen 1
astrocytes 1
nucleus 1
PBMC 1
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 7 99.84 Very High Very High Very High
Inflammation 26 99.18 Very High Very High Very High
Spinal cord 12 98.84 Very High Very High Very High
aspirin 29 98.34 Very High Very High Very High
dexamethasone 13 97.92 Very High Very High Very High
diclofenac 2 96.40 Very High Very High Very High
Inflammatory response 6 94.20 High High
intrathecal 8 93.84 High High
cytokine 33 90.28 High High
Sciatic nerve 2 84.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 40 99.18 Very High Very High Very High
Nociception 2 94.40 High High
Necrosis 7 91.00 High High
Cancer 10 90.64 High High
Pressure And Volume Under Development 1 87.36 High High
Neuropathic Pain 8 83.96 Quite High
Headache 5 81.52 Quite High
Pain 8 75.00 Quite High
Endotoxemia 2 70.88 Quite High
Adhesions 2 70.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPS stimulation of rat PBMC increased TNFalpha production and NFkappaB activation, with corresponding loss of IkappaBalpha.
Negative_regulation (loss) of IkappaBalpha in PBMC
1) Confidence 0.51 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 12175093 Disease Relevance 0.13 Pain Relevance 0.39
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Neg (No) Negative_regulation (levels) of IkappaBalpha mRNA in astrocytes associated with intrathecal and spinal cord
2) Confidence 0.35 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.79 Pain Relevance 1.26
RESULTS: After i.p. injection of LPS, the expression of NF-kappaB in the nuclear extracts was significantly increased and I kappaB alpha in the cytosol extracts was markedly decreased.
Negative_regulation (decreased) of I kappaB alpha
3) Confidence 0.16 Published 2008 Journal Pharmacology Section Body Doc Link 17785997 Disease Relevance 0.07 Pain Relevance 0
No or low levels of IkappaBalpha mRNA were detected in the lumbar spinal cord of vehicle-injected rats, whereas IkappaBalpha mRNA expression was markedly induced in the spinal cord following intrathecal gp120 in predominantly astrocytes and endothelial cells.
Neg (No) Negative_regulation (levels) of IkappaBalpha mRNA in endothelial cells associated with intrathecal and spinal cord
4) Confidence 0.12 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16262636 Disease Relevance 0.79 Pain Relevance 1.26
Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).
Negative_regulation (inhibitor) of kappa B-alpha in nucleus
5) Confidence 0.10 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.66 Pain Relevance 0.23
All drugs inhibited IkappaBalpha kinase and suppressed IkappaBalpha degradation and NF-kappaB-regulated reporter gene expression.
Negative_regulation (inhibited) of IkappaBalpha
6) Confidence 0.08 Published 2004 Journal Oncogene Section Abstract Doc Link 15489888 Disease Relevance 0.57 Pain Relevance 0.67
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Negative_regulation (decrease) of IkappaB-alpha
7) Confidence 0.05 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.36 Pain Relevance 0.70
L-N(6)-(1-iminoethyl)lysine, a selective iNOS inhibitor, attenuates the NO signal, emphasizing the importance of enzymatic activity to delayed NO production. iNOS expression is preceded by significant nuclear factor kappa B (NF-kappaB) activity, as reflected by a reduction in the inhibitory protein-kappa-Balpha (IkappaBalpha) and activation of NF-kappaB after GTN infusion.
Negative_regulation (reduction) of IkappaBalpha
8) Confidence 0.05 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.68 Pain Relevance 0.54
IL-1beta caused a rapid increase in phosphorylated IkappaB-alpha levels and subsequent transient decrease in IkappaB-alpha levels, an inhibitor of NF-kappaB, as revealed by Western blot analysis using specific antibodies for phosphorylated and nonphosphorylated IkappaB-alpha.
Negative_regulation (decrease) of IkappaB-alpha
9) Confidence 0.04 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.36 Pain Relevance 0.70
Concomitantly, ASA inhibited nuclear factor (NF)-kappaB activity, as well as the phosphorylation and breakdown of the inhibitory protein IkappaB-alpha.
Negative_regulation (breakdown) of IkappaB-alpha associated with aspirin
10) Confidence 0.00 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 15763541 Disease Relevance 0.51 Pain Relevance 0.67
In this study, we investigated the early signaling events responsible for modulating NF-kappaB activation using various parameters, such as the expression of pro-inflammatory genes and the phosphorylation levels of inhibitor of kappaB alpha (IkappaB alpha) and its upstream kinases.
Negative_regulation (inhibitor) of kappaB alpha associated with inflammation
11) Confidence 0.00 Published 2009 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 18775507 Disease Relevance 0.36 Pain Relevance 0.18
Distinct role of spleen tyrosine kinase in the early phosphorylation of inhibitor of kappaB alpha via activation of the phosphoinositide-3-kinase and Akt pathways.
Negative_regulation (inhibitor) of kappaB alpha in spleen
12) Confidence 0.00 Published 2009 Journal Int. J. Biochem. Cell Biol. Section Title Doc Link 18775507 Disease Relevance 0.33 Pain Relevance 0.17
Total levels of the NF-kappaB inhibitor Ikappa-Balpha were reduced during exposure to VP-16.
Negative_regulation (reduced) of Ikappa-Balpha
13) Confidence 0.00 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11322928 Disease Relevance 0.12 Pain Relevance 0.03

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