INT81542

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 1999
Last Reported 2003
Negated 1
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkbia) plasma membrane (Nfkbia) nucleus (Nfkbia)
enzyme binding (Nfkbia) protein complex (Nfkbia) cytoplasm (Nfkbia)
Nfkbia (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 9 99.08 Very High Very High Very High
COX2 1 99.08 Very High Very High Very High
cytokine 6 98.36 Very High Very High Very High
dexamethasone 5 96.52 Very High Very High Very High
cINOD 4 95.60 Very High Very High Very High
Inflammation 4 88.00 High High
COX-2 inhibitor 2 82.92 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 3 98.64 Very High Very High Very High
INFLAMMATION 6 95.40 Very High Very High Very High
Necrosis 1 45.88 Quite Low
Cancer 1 45.52 Quite Low
Immune System Diseases 1 30.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study demonstrates that 1) inhibitory effect of dexamethasone on cytokine-induced iNOS expression and NO production in rat VSMCs, although potentially acting at multiple levels, is partly mediated by inhibition of NF-kappaB activation resulting from decreased phosphorylation and degradation of IkappaB-alpha, 2) both salicylate and aspirin inhibit cytokine-stimulated NO production at translational and/or posttranslational levels without affecting NF-kappaB- mediated iNOS gene expression, and 3) aspirin directly inhibits iNOS enzyme activity.
Regulation (resulting) of Protein_catabolism (degradation) of IkappaB-alpha associated with aspirin, dexamethasone and cytokine
1) Confidence 0.04 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0 Pain Relevance 0.71
Suppression of RelA/p65 nuclear translocation independent of IkappaB-alpha degradation by cyclooxygenase-2 inhibitor in gastric cancer.
Neg (independent) Regulation (independent) of Protein_catabolism (degradation) of IkappaB-alpha associated with aspirin and stomach cancer
2) Confidence 0.00 Published 2003 Journal Oncogene Section Title Doc Link 12606945 Disease Relevance 0.43 Pain Relevance 0.31

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox