INT81545

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Context Info
Confidence 0.03
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tnf, Gtf3a) DNA binding (Gtf3a) extracellular matrix organization (Tnf)
extracellular space (Tnf) signal transduction (Tnf) extracellular region (Tnf)
Tnf (Rattus norvegicus)
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 10 99.96 Very High Very High Very High
Inflammation 14 98.92 Very High Very High Very High
dexamethasone 5 94.40 High High
aspirin 7 92.00 High High
cINOD 3 85.08 High High
Sciatic nerve 9 78.68 Quite High
Peripheral nerve injury 6 35.28 Quite Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Neuropathic pain 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
INFLAMMATION 19 98.92 Very High Very High Very High
Nervous System Injury 9 98.76 Very High Very High Very High
Neurological Disease 1 92.04 High High
Immune System Diseases 1 75.76 Quite High
Injury 8 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Neuritis 1 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One of these cytokines, Tumor necrosis factor alpha (TNF-alpha), is known to induce nuclear factor kappab (NF-kappab) activation, a transcription factor that promotes further pro-inflammatory cytokine production in inflammatory cells [19].
Tumor necrosis factor alpha Positive_regulation (induce) of factor associated with necrosis, inflammation, cancer and cytokine
1) Confidence 0.03 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2607269 Disease Relevance 0.93 Pain Relevance 0.45
Both IL-1beta and TNF-alpha activated nuclear factor (NF)-kappaB as demonstrated by electrophoretic mobility shift assay.
TNF-alpha Positive_regulation (activated) of factor
2) Confidence 0.02 Published 1999 Journal Endocrinology Section Abstract Doc Link 10218970 Disease Relevance 0.49 Pain Relevance 0.57

General Comments

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