INT81550

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Context Info
Confidence 0.35
First Reported 1999
Last Reported 2001
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.20
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pmp22) cell cycle (Pmp22)
Pmp22 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 10 97.92 Very High Very High Very High
Endogenous opioid 2 95.24 Very High Very High Very High
Pain 2 65.52 Quite High
Disease Link Frequency Relevance Heat
Paralysis 8 100.00 Very High Very High Very High
Neuropathy 18 99.92 Very High Very High Very High
Demyelinating Disease 8 99.48 Very High Very High Very High
Syndrome 4 87.60 High High
Disease 5 81.52 Quite High
Peripheral Neuropathy 2 79.20 Quite High
Neuroblastoma 2 75.04 Quite High
Brachial Plexus Neuritis 2 73.60 Quite High
Charcot Marie Tooth Disease 12 72.76 Quite High
Brachial Plexus Neuropathies 2 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous reports have suggested that this 22-kDa (125)I-beta-endorphin cross-linked protein could be the degradative product from a higher molecular mass species, i.e., a fragment of the receptor.
22-kDa Binding (cross-linked) of
1) Confidence 0.35 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10854259 Disease Relevance 0.08 Pain Relevance 0.20
Although neither the carboxyl terminus mu-opioid receptor-specific antibodies nor the antibodies against the epitope at the amino terminus of the receptor could recognize the 22-kDa protein, this (125)I-beta-endorphin cross-linked species could be coimmunoprecipitated with the receptor antibodies or could be isolated with a nickel resin affinity chromatography.
22-kDa Neg (neither) Binding (recognize) of associated with opioid receptor
2) Confidence 0.35 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10854259 Disease Relevance 0.07 Pain Relevance 0.16
HNPP is associated with a 1.5-Mb deletion in chromosome 17p11.2-12 and results from reduced expression of the PMP22 gene.
HNPP Binding (associated) of associated with paralysis
3) Confidence 0.03 Published 1999 Journal Brain Pathol. Section Abstract Doc Link 10219749 Disease Relevance 2.07 Pain Relevance 0.07
HNPP is associated with a 1.5-Mb deletion in chromosome 17p11.2-12 and results from reduced expression of the PMP22 gene.
HNPP Binding (associated) of associated with paralysis
4) Confidence 0.03 Published 2001 Journal Phys Med Rehabil Clin N Am Section Abstract Doc Link 11345007 Disease Relevance 1.99 Pain Relevance 0.07

General Comments

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