INT8157

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Context Info
Confidence 0.09
First Reported 1982
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 0.64
Pain Relevance 5.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
brain 3
cleavage 1
vesicle 1
dorsal horn 1
motoneuron 1
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 34 100.00 Very High Very High Very High
orphanin 12 100.00 Very High Very High Very High
Dorsal horn 4 99.84 Very High Very High Very High
Enkephalin 27 99.64 Very High Very High Very High
Opioid 7 99.36 Very High Very High Very High
opiate 3 97.52 Very High Very High Very High
Neurotransmitter 3 97.08 Very High Very High Very High
opioid receptor 1 96.40 Very High Very High Very High
Intracerebroventricular 2 93.64 High High
Thalamus 3 92.76 High High
Disease Link Frequency Relevance Heat
Stress 9 93.16 High High
Disease Susceptibility 1 85.48 High High
Disease 4 77.64 Quite High
Low Back Pain 2 73.72 Quite High
Shock 7 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The relevance of the single peptide replacement and of its association to acetylation or amino group elimination of Tyr, is discussed on the basis of a receptor model for mu and delta opioids.
Tyr Binding (association) of associated with opioid
1) Confidence 0.09 Published 1992 Journal Int. J. Pept. Protein Res. Section Abstract Doc Link 1362392 Disease Relevance 0 Pain Relevance 0.15
Free Tyr, furthermore, inhibits the association to cells of both labelled Tyr and leu-enkephalin.
Tyr Binding (association) of associated with enkephalin
2) Confidence 0.09 Published 1992 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 1521931 Disease Relevance 0 Pain Relevance 0.39
The effect of the association of Tyr-Phe-NHOH (0.17 mumol, 60 micrograms), bestatin (0.16 mumol, 50 micrograms) and thiorphan (0.20 mumol, 50 micrograms) is not statistically different from that produced by bestatin (0.16 mumol) plus thiorphan (0.20 mumol).
Tyr Binding (association) of
3) Confidence 0.07 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3531805 Disease Relevance 0 Pain Relevance 0.31
The phenotype of the calorie-independent IF-specific genes in the males contained the following GO term motifs: steroidal function (cholesterol metabolism); intracellular vesicle dynamics (intracellular transport, microtubule cytoskeleton organization, regulation of endocytosis); regulation of protein catabolism/degradation (proteolysis during cellular protein catabolism, ubiquitin-dependent protein catabolism, protein ubiquitination, ubiquitin cycle, small conjugating protein-specific protease activity, cysteine-type endopeptidase activity); cell signaling activity (signal transduction, amino acid phosphorylation, ATP binding, Ser/Thr kinase activity, Tyr kinase activity); transcriptional/translational regulation (RNA polymerase II activity, nuclear mRNA splicing, transcriptional coactivator activity, regulation of translation); stress management (response to stress).
Tyr kinase Binding (binding) of in vesicle associated with stress
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607546 Disease Relevance 0.19 Pain Relevance 0
It seems that the rigid structure of the N-terminal part of I-V results from the interaction of the Tyr(1) side chain and the tetrazole ring.
Tyr Binding (interaction) of
5) Confidence 0.06 Published 2006 Journal J. Pept. Sci. Section Abstract Doc Link 16180245 Disease Relevance 0 Pain Relevance 0.13
Met-enkephalin-Arg6-Phe7 (E7) is converted to Met-enkephalin by rat striatal membranes; in contrast, Leu-enkephalin (E5) is inactivated by cleavage at the Tyr-Gly (aminopeptidase) and Gly-Phe sites (metalloendopeptidase).
Tyr-Gly Binding (cleavage) of in cleavage associated with enkephalin
6) Confidence 0.03 Published 1982 Journal Life Sci. Section Abstract Doc Link 7154837 Disease Relevance 0 Pain Relevance 0.72
These results suggest that [125I][Tyr14] orphanin binding in rat brain occurs to the described ORL1 receptor.
Tyr14 Binding (binding) of in brain associated with orphanin
7) Confidence 0.03 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259475 Disease Relevance 0 Pain Relevance 0.57
[125I][Tyr14]Orphanin binding to rat brain: evidence for labelling the opioid-receptor-like 1 (ORL1).

[125I][Tyr14]Orphanin binds to a number of saturable non-interacting binding sites in rat brain cortical membrane preparations, with a density of 510 fmol/mg protein and affinity 0.9 nM.

Tyr14 Binding (binds) of in brain associated with orphanin and opioid
8) Confidence 0.03 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9259475 Disease Relevance 0 Pain Relevance 0.62
This high affinity, saturable [125I][Tyr14]orphanin binding was not inhibited by leu-enkephalin and by other ligands for opiate and neurotransmitter receptors both in membrane preparations and brain sections.
Tyr14 Binding (binding) of in brain associated with neurotransmitter, orphanin, opiate and enkephalin
9) Confidence 0.03 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259475 Disease Relevance 0 Pain Relevance 0.59
Loss of single acidic charges (D > S77, D > Y116) increased preference for C-terminal Leu and Phe, but allowed efficient binding of peptides with basic residues or Tyr.
Tyr Binding (binding) of
10) Confidence 0.03 Published 1996 Journal Tissue Antigens Section Abstract Doc Link 8988533 Disease Relevance 0.22 Pain Relevance 0.07
Thus, the main structural feature of peptides differentially bound to B*2704 was the presence of C-terminal Tyr or Arg, together with a strong preference for aliphatic/aromatic P3 residues.
Tyr Binding (bound) of
11) Confidence 0.03 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11875071 Disease Relevance 0.24 Pain Relevance 0.07
Further study indicated that the unfolded state of the peptide was not random in nature and consisted of one major unfolded backbone arrangement stabilized by a persistent hydrophobic interaction between the side chains of Tyr and Leu.
Tyr Binding (interaction) of
12) Confidence 0.02 Published 2002 Journal Biopolymers Section Abstract Doc Link 12115135 Disease Relevance 0 Pain Relevance 0.22
Within the superficial laminae of the dorsal horn, [125I-Tyr8]bradykinin binding was largely distributed over the neurophil with some perikarya showing concentrations of labelling.
Tyr8 Binding (binding) of in dorsal horn associated with dorsal horn and bradykinin
13) Confidence 0.01 Published 1995 Journal Neuroscience Section Abstract Doc Link 8577380 Disease Relevance 0 Pain Relevance 0.92
In contrast, the ventral horn showed a rather homogeneous distribution of [125I-Tyr8]bradykinin binding over the neuropil, with silver grain alignments surrounding motoneuron perikaryas and proximal processes.
Tyr8 Binding (binding) of in motoneuron associated with bradykinin
14) Confidence 0.01 Published 1995 Journal Neuroscience Section Abstract Doc Link 8577380 Disease Relevance 0 Pain Relevance 1.13

General Comments

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