INT81575

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Context Info
Confidence 0.25
First Reported 1999
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 19.76
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (SIL1) protein folding (SIL1) endoplasmic reticulum (SIL1)
Anatomy Link Frequency
brain 4
plasma 3
lung 3
blood 1
A549 1
SIL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 259 99.16 Very High Very High Very High
cytokine 10 81.88 Quite High
aspirin 5 75.00 Quite High
analgesia 5 71.24 Quite High
Arthritis 5 70.96 Quite High
Analgesic 3 64.80 Quite High
rheumatoid arthritis 15 64.00 Quite High
Inflammatory response 44 54.80 Quite High
Inflammatory stimuli 5 53.52 Quite High
Pain 10 50.00 Quite Low
Disease Link Frequency Relevance Heat
Stress 1303 100.00 Very High Very High Very High
Cancer 765 100.00 Very High Very High Very High
Syndrome 54 100.00 Very High Very High Very High
Insulin Resistance 30 100.00 Very High Very High Very High
Hyperlipidemia 2 99.80 Very High Very High Very High
Hypoxia 228 99.58 Very High Very High Very High
Lung Cancer 893 99.28 Very High Very High Very High
INFLAMMATION 332 99.16 Very High Very High Very High
Periodontitis 95 98.26 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

6 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Salicylates inhibited ATPase activity stimulated by this specific heptapeptide but did not block ATP binding or induce BiP expression.
Gene_expression (expression) of BiP
1) Confidence 0.25 Published 2001 Journal FASEB J. Section Abstract Doc Link 11689471 Disease Relevance 0.12 Pain Relevance 0.27
Effect of CS exposure on the expression of BiP in human lung cells
Gene_expression (expression) of BiP in lung
2) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.29 Pain Relevance 0
In addition, hypoxia can also induce the expression of BiP [155].
Gene_expression (expression) of BiP associated with hypoxia
3) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.64 Pain Relevance 0
We speculated that this apparent discrepancy in BiP expression could be due to the fact that we exposed short-term cultures of untransformed NHBE cells (as opposed to rodent cells or virally-transformed bronchial cells).
Gene_expression (expression) of BiP
4) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.24 Pain Relevance 0
A recent lung cancer study by Wang et al. [148], though finding no correlation of increased expression of BiP with pathologic tumor type, did relate augmented expression in less differentiated tumors and in more advanced stage III tumors, both aspects predicting a poorer prognosis.
Gene_expression (expression) of BiP in lung associated with lung cancer and cancer
5) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.17 Pain Relevance 0
Uramoto et al. [149] similarly found no significant difference between BiP expression and any clinicopathological parameter.
Gene_expression (expression) of BiP
6) Confidence 0.18 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.20 Pain Relevance 0
, BiP, and Lamin A/C, 1:200 dilution for ATF3 and ATF4, 1:500 for ATF6, 1:2000 for ?
Gene_expression (1:500) of BiP
7) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
Consequently, these data, while agreeing with previous reports showing that BiP expression is induced by CS [30,31], clearly show that BiP induction can be modulated depending on level and duration of stress-inducing conditions.
Gene_expression (expression) of BiP associated with stress
8) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.47 Pain Relevance 0
and BiP (and possibly eIF2?)
Gene_expression (possibly) of BiP
9) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.25 Pain Relevance 0
Identical TMAs were immunostained with one of the following antibodies: a) a rabbit monoclonal anti-BiP antibody (Cell Signaling Technology, Danvers MA, cat. # 3177) recognizing BiP (C50B12) from rabbits immunized with a synthetic peptide derived from the sequence around Gly584 of human BiP (used at 1:200 dilution and a concentration of 1 ?
Gene_expression (antibody) of BiP
10) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.27 Pain Relevance 0
However, Uramoto et al. [149] found increased expression of BiP in a majority of lung cancers but these patients had a better prognosis than those with BiP-negative cancers.
Gene_expression (expression) of BiP in lung associated with lung cancer and cancer
11) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.02 Pain Relevance 0
In contrast to these studies, our results show that when A549 cells (Figure 6, Panel A) or NHBE cells (data not shown) were briefly exposed to freshly generated whole CS for 20 min, Western blot analysis showed no increase of BiP protein levels up to 72 h post-exposure.
Gene_expression (levels) of BiP protein in A549
12) Confidence 0.16 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.26 Pain Relevance 0
Serum levels of OC, BAP, ACP, and TRAP were measured in blood samples drawn on Days 0, 4, 5, 6, and 14.
Gene_expression (levels) of BAP in blood
13) Confidence 0.15 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.08 Pain Relevance 0
Evidence to support this idea comes from numerous studies showing the increased expression of one or more UPR-relevant proteins in multiple tumors including those of the breast (i.e., BiP [144]), liver (ATF6, XBP1 and BiP [145]), stomach (BiP [146]), brain (BiP [143]), esophagus (Grp94 [147]), and lung (BiP and Grp94 [148,149]).
Gene_expression (expression) of BiP in brain associated with cancer
14) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.04 Pain Relevance 0
We further found a significant increase in expression of BiP in a majority of cases of NSCLCs (87.5%; p = < 0.0001) and MCs (100%; p = < 0.0001), but not in SCLCs.
Gene_expression (expression) of BiP
15) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.98 Pain Relevance 0
M thapsigargin continuously for 72 h, BiP expression is still only seen after 24 hours post-treatment, indicating that BiP induction is a much later consequence of ER stress than is eIF2?
Gene_expression (expression) of BiP associated with stress
16) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.39 Pain Relevance 0
Of the 95 assessable cases of NSCLCs, 83 (87.3%) showed a significant increase in expression of BiP with an ISI between > 1–12.
Gene_expression (expression) of BiP
17) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.20 Pain Relevance 0
Evidence to support this idea comes from numerous studies showing the increased expression of one or more UPR-relevant proteins in multiple tumors including those of the breast (i.e., BiP [144]), liver (ATF6, XBP1 and BiP [145]), stomach (BiP [146]), brain (BiP [143]), esophagus (Grp94 [147]), and lung (BiP and Grp94 [148,149]).
Gene_expression (expression) of BiP in brain associated with cancer
18) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 1.06 Pain Relevance 0
cat#3597, BiP cat#3183, Lamin A/C cat#2032 & ?
Gene_expression (cat) of BiP
19) Confidence 0.14 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
Levels of BAP were increased (p<0.05) over baseline on Days 4, 5, and 6, while those of OC decreased on Days 4, 5, and 6 (p<0.05).
Gene_expression (Levels) of BAP
20) Confidence 0.13 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.07 Pain Relevance 0

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