INT81578

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Context Info
Confidence 0.72
First Reported 1994
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 25
Total Number 25
Disease Relevance 9.75
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoclasts 4
histiocyte 2
foreign body giant cells 2
mandible 1
platelet 1
TRAP (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 6 99.68 Very High Very High Very High
rheumatoid arthritis 21 98.30 Very High Very High Very High
Arthritis 182 97.78 Very High Very High Very High
Analgesic 9 96.28 Very High Very High Very High
headache 3 96.26 Very High Very High Very High
Pain 52 95.66 Very High Very High Very High
anesthesia 2 95.60 Very High Very High Very High
Paresthesia 4 94.72 High High
Cannabinoid 2 94.24 High High
palliative 2 89.04 High High
Disease Link Frequency Relevance Heat
Adhesions 5 100.00 Very High Very High Very High
Necrosis 31 99.82 Very High Very High Very High
Rabies Virus Infection 27 99.76 Very High Very High Very High
Cancer 87 99.64 Very High Very High Very High
Pox Virus Infection 6 99.44 Very High Very High Very High
Foreign Bodies 6 99.36 Very High Very High Very High
Carcinoma 18 99.08 Very High Very High Very High
Sprains And Strains 23 98.92 Very High Very High Very High
Fowlpox 5 98.78 Very High Very High Very High
Rheumatoid Arthritis 21 98.30 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although it often causes irregular destruction of the adjacent bone, immunohistochemical expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor has not previously been described in this carcinoma.
Gene_expression (expression) of TRAP associated with carcinoma
1) Confidence 0.72 Published 2008 Journal J Craniomaxillofac Surg Section Abstract Doc Link 18674923 Disease Relevance 0.45 Pain Relevance 0.14
TRAP and vitronectin receptor were detected in the ghost cells, but they were not expressed in the tumour cells.
Gene_expression (detected) of TRAP
2) Confidence 0.72 Published 2008 Journal J Craniomaxillofac Surg Section Body Doc Link 18674923 Disease Relevance 0.08 Pain Relevance 0
Cytological features including the immunohistochemical expression of TRAP and vitronectin receptor were studied.
Gene_expression (expression) of TRAP
3) Confidence 0.72 Published 2008 Journal J Craniomaxillofac Surg Section Body Doc Link 18674923 Disease Relevance 0.09 Pain Relevance 0
Ghost cell odontogenic carcinoma of the mandible: a case report demonstrating expression of tartrate-resistant acid phosphatase (TRAP) and vitronectin receptor.
Gene_expression (expression) of TRAP in mandible associated with carcinoma
4) Confidence 0.72 Published 2008 Journal J Craniomaxillofac Surg Section Title Doc Link 18674923 Disease Relevance 0.39 Pain Relevance 0.14
Splenectomy and age at diagnosis affected TRAP levels, with the former influencing the decrease rate (slope) and the latter the baseline concentration (Figure 2e).
Gene_expression (levels) of TRAP
5) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.07 Pain Relevance 0
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Gene_expression (levels) of TRAP in platelet
6) Confidence 0.50 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
OPN was localized in two distinct cell types, i.e., fibroblast-like cells negative for CD68 and tartrate-resistant acid phosphatase (TRAP) and multinucleated macrophages positive for CD68 and TRAP.
Neg (negative) Gene_expression (negative) of TRAP in macrophages
7) Confidence 0.46 Published 2001 Journal Virchows Arch. Section Abstract Doc Link 11469694 Disease Relevance 0.39 Pain Relevance 0.14
Serum levels of OC, BAP, ACP, and TRAP were measured in blood samples drawn on Days 0, 4, 5, 6, and 14.
Gene_expression (levels) of TRAP in blood
8) Confidence 0.44 Published 1999 Journal Transfusion Section Body Doc Link 10220269 Disease Relevance 0.08 Pain Relevance 0
These multinucleated giant cells were positive for tartrate-resistant acid phosphatase (TRAP) and had the ability to absorb bone.
Gene_expression (positive) of TRAP in multinucleated giant cells
9) Confidence 0.42 Published 2007 Journal Osteoarthr. Cartil. Section Body Doc Link 16979913 Disease Relevance 0 Pain Relevance 0
Phenotypic resemblance of OGCs to the osteoclasts in the bone was confirmed with expression of MMP9, TRAP, and cathepsin K.
Gene_expression (expression) of TRAP in osteoclasts
10) Confidence 0.39 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.86 Pain Relevance 0.18
The OGCs expressed bone-osteoclast markers (MMP9, TRAP, cathepsin K) and a histiocyte marker (CD68), but not an MHC class II antigen, HLA-DR.
Neg (not) Gene_expression (expressed) of TRAP in histiocyte
11) Confidence 0.39 Published 2010 Journal Diagn Pathol Section Abstract Doc Link PMC2936386 Disease Relevance 0.77 Pain Relevance 0.08
Consistently, biomolecular and functional experiments showed that resiniferatoxin (RTX), a selective TRPV1 receptor agonist, increased the expression and the activity of TRAP and cathepsin K, two specific osteoclast biomarkers.
Gene_expression (expression) of TRAP in osteoclast associated with agonist
12) Confidence 0.35 Published 2009 Journal Bone Section Abstract Doc Link 19059369 Disease Relevance 0.07 Pain Relevance 0.32
Our results did not show any statistically significant difference in baseline serum TRAP levels in the two groups.
Gene_expression (levels) of TRAP
13) Confidence 0.33 Published 2002 Journal Int. J. Biol. Markers Section Abstract Doc Link 12521129 Disease Relevance 0.47 Pain Relevance 0.50
In four cases of TRAP sequence presenting at 17, 20, 26 and 28 weeks' gestation, respectively, an endoscope was introduced into the uterus under local anesthesia and a Nd-YAG laser was used to coagulate the umbilical cord vessels of the acardiac twin.
Gene_expression (presenting) of TRAP in vessels associated with anesthesia
14) Confidence 0.32 Published 1994 Journal Ultrasound Obstet Gynecol Section Abstract Doc Link 12797148 Disease Relevance 0.10 Pain Relevance 0.10
Unexpectedly, foreign body giant cells were also strongly positive for TRAP (Figure 3L), although they were negative for cathepsin K (Figure 3P).
Gene_expression (positive) of TRAP in foreign body giant cells associated with foreign bodies
15) Confidence 0.29 Published 2010 Journal Diagn Pathol Section Body Doc Link PMC2936386 Disease Relevance 0.82 Pain Relevance 0.06
A novel immunoassay specific for the osteoclast-produced TRAP isoform 5b has been developed recently.
Gene_expression (osteoclast-produced) of TRAP in osteoclast
16) Confidence 0.29 Published 2002 Journal Int. J. Biol. Markers Section Abstract Doc Link 12521129 Disease Relevance 0.45 Pain Relevance 0.24
OC culture and TRAP staining
Gene_expression (staining) of TRAP
17) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0 Pain Relevance 0
During ERT, clinical abnormality rates decreased (except for neurological involvement) and the biological data improved overall during ERT (increased hemoglobin, leukocyte and platelet levels; decreased chitotriosidase, ACE, TRAP, ferritin and gammaglobulin levels).
Gene_expression (levels) of TRAP in leukocyte
18) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.28 Pain Relevance 0
Injection site pain, limited arm motion, headache, and malaise in the first 24 h after vaccination (mild to moderate in intensity, i.e., not preventing activities of daily living, in all but one volunteer) were more common after MVA ME-TRAP vaccination than rabies vaccination (Table 2).
Gene_expression (vaccination) of TRAP in arm associated with pain, rabies virus infection and headache
19) Confidence 0.15 Published 2004 Journal PLoS Medicine Section Body Doc Link PMC524376 Disease Relevance 0.90 Pain Relevance 0.27
Cultured osteoclasts are multinucleated, express tartrate resistant acid phosphatase (TRAP), form F-actin rings and resorb bone.
Gene_expression (express) of TRAP in osteoclasts
20) Confidence 0.13 Published 2002 Journal Res. Vet. Sci. Section Abstract Doc Link 12443687 Disease Relevance 0.32 Pain Relevance 0.08

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