INT81586

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Context Info
Confidence 0.57
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 6.55
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
spinal cord 2
spinal 1
glial cell 1
cleavage 1
skin 1
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 43 99.92 Very High Very High Very High
aspirin 27 99.70 Very High Very High Very High
cytokine 40 99.60 Very High Very High Very High
allodynia 5 99.16 Very High Very High Very High
intrathecal 5 98.76 Very High Very High Very High
Hyperalgesia 5 98.34 Very High Very High Very High
Spinal cord 17 97.68 Very High Very High Very High
Dorsal horn 9 97.48 Very High Very High Very High
Inflammation 83 96.80 Very High Very High Very High
cINOD 69 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 13 99.16 Very High Very High Very High
Hyperalgesia 6 98.34 Very High Very High Very High
INFLAMMATION 80 96.80 Very High Very High Very High
Apoptosis 14 96.64 Very High Very High Very High
Disease 16 96.28 Very High Very High Very High
Cv Unclassified Under Development 22 96.24 Very High Very High Very High
Necrosis 7 92.44 High High
Cancer 4 92.08 High High
Myelitis 9 91.88 High High
Toxicity 2 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
by inhibiting gastric caspase-1 activity [101].
Negative_regulation (inhibiting) of caspase-1
1) Confidence 0.57 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582806 Disease Relevance 0.39 Pain Relevance 1.20
Gastrointestinal safety of nitric oxide-derived aspirin is related to inhibition of ICE-like cysteine proteases in rats.
Negative_regulation (inhibition) of ICE associated with aspirin
2) Confidence 0.42 Published 1999 Journal Gastroenterology Section Title Doc Link 10220501 Disease Relevance 0.28 Pain Relevance 0.71
In behavioural studies, intrathecal injection of LPS in the lumbar spinal cord produced mechanical hyperalgesia in the rat hind-paws which was attenuated by concomitant injections of a p38 MAPK inhibitor, a caspase 1 inhibitor or the rat recombinant interleukin 1 receptor antagonist.
Negative_regulation (inhibitor) of caspase 1 in spinal cord associated with hyperalgesia, antagonist, spinal cord and intrathecal
3) Confidence 0.41 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.56 Pain Relevance 0.69
Following application of lipopolysaccharide (LPS) to an ex vivo dorsal horn slice preparation, we observed rapid secretion of IL-1beta which was prevented by inhibition of glial cell metabolism and by inhibitors of either p38 mitogen-activated protein kinase (MAPK) or caspase 1.
Negative_regulation (inhibitors) of caspase 1 in glial cell associated with dorsal horn
4) Confidence 0.41 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.66 Pain Relevance 0.51
Using this model we observed that: (1) inflammasome components and products NALP1, caspase-1, IL-1beta and IL-18 were present in low levels in normal skin, but expression of all these was strongly up-regulated after fracture, (2) NALP1, caspase-1 and IL-1beta were co-expressed in keratinocytes, and the number of NALP1, caspase-1, and IL-1beta positive cells dramatically increased at 4 weeks post-fracture, (3) LY303870, an NK1 receptor antagonist, effectively blocked fracture-induced up-regulation of activated inflammasome components and cytokines, (4) IL-1beta and IL-18 intraplantar injection induced mechanical allodynia in normal rats, and (5) both a selective caspase-1 inhibitor and an IL-1 receptor antagonist attenuated fracture-induced hindpaw mechanical allodynia.
Negative_regulation (inhibitor) of caspase-1 in skin associated with allodynia, antagonist and cytokine
5) Confidence 0.36 Published 2009 Journal Pain Section Abstract Doc Link 19853379 Disease Relevance 0.78 Pain Relevance 0.70
In behavioural studies, intrathecal injection of LPS in the lumbar spinal cord produced mechanical hyperalgesia in the rat hind-paws which was attenuated by concomitant injections of a p38 MAPK inhibitor, a caspase 1 inhibitor or the rat recombinant interleukin 1 receptor antagonist.
Negative_regulation (inhibitor) of caspase 1 in spinal cord associated with hyperalgesia, antagonist, spinal cord and intrathecal
6) Confidence 0.30 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.55 Pain Relevance 0.69
Immunoblot analysis demonstrated that Q-VD-OPh inhibits caspase 3 cleavage into its p17 active form and caspase 1 up-regulation and cleavage in vivo.
Negative_regulation (inhibits) of caspase 1 in cleavage
7) Confidence 0.19 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17166174 Disease Relevance 0.93 Pain Relevance 0.09
Reducing IL-1beta and IL-18 production by inhibition of IL-1beta converting enzyme (ICE, caspase-1) is one promising strategy because of the key roles of these cytokines in many inflammatory diseases.
Negative_regulation (inhibition) of caspase-1 associated with inflammation, disease and cytokine
8) Confidence 0.06 Published 2001 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11772244 Disease Relevance 0.50 Pain Relevance 0.49
In a series of elegant experiments, Boost and collaborators showed that a caspase-1 inhibitor administered by inhalation in endotoxemic rats decreased IL-1 and IL-18 levels in bronchoalveolar lavage fluid [18].
Negative_regulation (inhibitor) of caspase-1
9) Confidence 0.04 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.77 Pain Relevance 0.43
Inhibitors of caspase-1 and caspase-3 effectively block P2X7 receptor-mediated IL-1?
Negative_regulation (Inhibitors) of caspase-1
10) Confidence 0.03 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.18 Pain Relevance 0.07
In addition, the activation of spinal NF-kB following CFA injection was inhibited by intrathecal pretreatments with interleukin-1 beta receptor antagonist or caspase-1 inhibitor.
Negative_regulation (inhibitor) of caspase-1 in spinal associated with antagonist and intrathecal
11) Confidence 0.01 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15217394 Disease Relevance 0.95 Pain Relevance 0.88

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