INT81596

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 3.41
Pain Relevance 6.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npff) extracellular region (Npff)
Anatomy Link Frequency
spinal cord 6
area postrema 2
polymodal neuron 2
brain 2
brainstem 2
Npff (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 25 100.00 Very High Very High Very High
Morphine 10 99.92 Very High Very High Very High
Spinal cord 19 99.86 Very High Very High Very High
Lasting pain 3 99.84 Very High Very High Very High
Dorsal horn 1 99.68 Very High Very High Very High
Inflammation 27 99.64 Very High Very High Very High
medulla 4 99.52 Very High Very High Very High
Analgesic 4 99.12 Very High Very High Very High
intrathecal 1 97.88 Very High Very High Very High
Neuropathic pain 2 97.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 18 99.64 Very High Very High Very High
Pain 10 99.40 Very High Very High Very High
Neuropathic Pain 4 97.48 Very High Very High Very High
Inflammatory Pain 1 94.88 High High
Nociception 9 92.76 High High
Cv Unclassified Under Development 4 83.52 Quite High
Hyperalgesia 3 75.00 Quite High
Urological Neuroanatomy 1 63.36 Quite High
Acidosis 1 53.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Central administration of neuropeptide FF (NPFF) causes increased neuronal activation and up-regulation of NPFF gene expression in the rat brainstem.
Positive_regulation (up-regulation) of Gene_expression (expression) of NPFF gene in brainstem associated with medulla and neuropeptide
1) Confidence 0.69 Published 2002 Journal J. Comp. Neurol. Section Title Doc Link 11984823 Disease Relevance 0.15 Pain Relevance 0.33
NPFF mRNA expression is upregulated in the dorsal horn of the spinal cord after carrageenan-induced inflammation in the hind paw of the rat, but not in the neuropathic pain model induced by ligation of the spinal roots.
Positive_regulation (upregulated) of Gene_expression (expression) of NPFF in dorsal horn associated with inflammation, neuropathic pain, dorsal horn and spinal cord
2) Confidence 0.50 Published 1999 Journal Brain Res. Section Abstract Doc Link 10612711 Disease Relevance 0.58 Pain Relevance 1.18
In the rat spinal cord, gene expression of NPFF but not that of NPVF was up-regulated by persistent pain induced by carrageenan inflammation.
Positive_regulation (up-regulated) of Gene_expression (expression) of NPFF in spinal cord associated with pain, inflammation, lasting pain and spinal cord
3) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.65 Pain Relevance 0.85
In rats with carrageenan inflammation of the hind paw, expression of both NPFF and NPFF receptor 2 genes was up-regulated in the spinal cord, while expression of NPVF and NPFF receptor 1 genes was not affected.
Positive_regulation (up-regulated) of Gene_expression (expression) of NPFF in spinal cord associated with inflammation and spinal cord
4) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.66 Pain Relevance 1.19
In rats with carrageenan inflammation of the hind paw, expression of both NPFF and NPFF receptor 2 genes was up-regulated in the spinal cord, while expression of NPVF and NPFF receptor 1 genes was not affected.
Positive_regulation (up-regulated) of Gene_expression (expression) of NPFF in spinal cord associated with inflammation and spinal cord
5) Confidence 0.50 Published 2003 Journal Neuroscience Section Abstract Doc Link 12676148 Disease Relevance 0.66 Pain Relevance 1.19
Significantly greater numbers of activated neurons expressing the NPFF gene (double labeled) were observed in the NTS at the level of the area postrema in animals receiving i.c.v.
Positive_regulation (activated) of Gene_expression (expressing) of NPFF gene in area postrema
6) Confidence 0.50 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11984823 Disease Relevance 0.08 Pain Relevance 0.11
Our results confirm the evolutionary conservation of NPFF, NPAF, and NPSF neuropeptide expression in mammalian brain.
Positive_regulation (conservation) of Gene_expression (expression) of NPFF in brain associated with neuropeptide
7) Confidence 0.49 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220558 Disease Relevance 0.43 Pain Relevance 0.92
ASIC3-mediated sustained depolarisation, and its regulation by neuropeptides, could thus be important in regulating polymodal neuron excitability particularly under inflammatory conditions where the expression levels of both NPFF precursor and ASIC3 are increased.
Positive_regulation (increased) of Gene_expression (expression) of NPFF in polymodal neuron associated with inflammation and neuropeptide
8) Confidence 0.09 Published 2003 Journal Neuropharmacology Section Abstract Doc Link 12668052 Disease Relevance 0.20 Pain Relevance 0.35

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