INT8160

Context Info Confidence 0.67 First Reported 1980 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 20 Total Number 20 Disease Relevance 4.83 Pain Relevance 8.17

peptidase activity (Prss12)

Anatomy Link Frequency ACe 2 nucleus accumbens 2 CER 1 ventricular system 1 central nervous system 1 Prss12 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Enkephalin 17 100.00 Nucleus accumbens 7 100.00 Dynorphin 6 100.00 Neurotransmitter 8 99.98 antinociception 19 99.96 Somatostatin 4 99.88 substance P 26 99.80 opioid receptor 2 99.76 Central nervous system 1 99.68 analgesia 7 98.68

Disease Link Frequency Relevance Heat Hypothermia 24 99.96 Fever 4 99.96 Stress 16 99.56 Nociception 20 98.92 Heat Stress Disorders 4 91.60 Pain 1 89.68 Lung Cancer 1 88.04 Targeted Disruption 4 77.04 Pulmonary Disease 1 74.84 Sprains And Strains 3 72.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, intense stress results in increased NT expression in several hypothalamic nuclei that have been implicated in stress-induced antinociception (SIAN); however, there is little direct evidence that endogenous NT is required for SIAN.

Gene_expression (expression) of NT associated with stress and antinociception

1) Confidence 0.67 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207335 Disease Relevance 1.10 Pain Relevance 0.70

Neurotensin (NT) produces behavioral and physiological effects, including analgesia and hypotheria, when administered into the CNS.

Gene_expression (produces) of NT associated with analgesia

2) Confidence 0.54 Published 2003 Journal Peptides Section Abstract Doc Link 14612190 Disease Relevance 0.34 Pain Relevance 0.32

However, higher doses of NT produce a mu-opioid receptor-independent analgesia, similar to that resulting from various intense stressors.

Gene_expression (produce) of NT associated with opioid receptor and analgesia

3) Confidence 0.52 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207335 Disease Relevance 0.89 Pain Relevance 0.61

When administered into the cerebroventricular system of the rat, neurotensin (NT) produces a variety of effects, including a decrease in colonic temperature and an increase in nociceptive threshold.

Gene_expression (produces) of NT associated with nociception

4) Confidence 0.51 Published 1982 Journal J. Comp. Neurol. Section Abstract Doc Link 7142439 Disease Relevance 0.17 Pain Relevance 0.07

In comparison, NT produces hypothermia in the posterior hypothalamus whatever the dose, and NT has analgesic effects in the preoptic area only at high doses.

Gene_expression (produces) of NT in preoptic area associated with hypothermia and analgesic

5) Confidence 0.47 Published 1996 Journal Brain Res. Bull. Section Abstract Doc Link 8705314 Disease Relevance 0.50 Pain Relevance 0.43

Injection of NT into the cerebral ventricular system of rodents produces antinociception in a variety of analgesia tests.

Gene_expression (produces) of NT in ventricular system associated with antinociception and analgesia

6) Confidence 0.47 Published 1982 Journal Brain Res. Section Abstract Doc Link 7104740 Disease Relevance 0.09 Pain Relevance 0.62

PL-017 induced dose-dependent hyperthermia; NT, DY and U50 produced dose-related hypothermia.

Gene_expression (produced) of NT associated with hypothermia and fever

7) Confidence 0.40 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7616410 Disease Relevance 0.61 Pain Relevance 0.23

Leu-enkephalin and calcitonin-gene-related-peptide (CGRP, 10(-7) M) produced a small rise in portal NT-LI, while Met-enkephalin, dynorphin, vasoactive intestinal peptide (VIP), galanin, neuropeptide Y (NPY), peptide histidine isoleucine (PHI), neuromedin U and thyrotropin releasing hormone (TRH) had no stimulatory effect.

Gene_expression (produced) of NT associated with dynorphin, neuropeptide and enkephalin

8) Confidence 0.26 Published 1991 Journal Regul. Pept. Section Abstract Doc Link 1674614 Disease Relevance 0 Pain Relevance 0.79

Neurotensin (NT), an endogenous tridecapeptide, produces significant hypothermia after intracisternal (i.c.) or intracerebroventricular (i.c.v.) administration in microgram quantities in a variety of laboratory animals.

Gene_expression (produces) of NT associated with hypothermia and intracerebroventricular

9) Confidence 0.25 Published 1980 Journal Brain Res. Section Abstract Doc Link 6446951 Disease Relevance 0.23 Pain Relevance 0.24

Neurotensin (NT), an endogenous tridecapeptide, is heterogeneously distributed in the central nervous system.

Gene_expression (distributed) of NT in central nervous system associated with central nervous system

10) Confidence 0.22 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6811728 Disease Relevance 0 Pain Relevance 0.24

In the present study, we report that VIP is significantly increased in the lungs and BAL fluids of rats exposed to asbestos while no significant change in the levels of Leu-Enk, Dyn, NT and SP is observed.

Gene_expression (levels) of NT in lungs associated with dynorphin and substance p

11) Confidence 0.18 Published 1983 Journal Life Sci. Section Abstract Doc Link 6196589 Disease Relevance 0.16 Pain Relevance 0.24

Combined infusion of SP, B and MC produced the largest output of NT.

Gene_expression (produced) of NT associated with substance p

12) Confidence 0.17 Published 1992 Journal Regul. Pept. Section Abstract Doc Link 1371613 Disease Relevance 0 Pain Relevance 0.77

Administration of monosodium glutamate (MSG) during the neonatal period in rats produced differential effects on the contents of various neuropeptides in the hypothalamus: beta-endorphin (beta-E) level was reduced by 70% while substance P (SP), neurotensin (NT) and Met5-enkephalin (ME) levels were not significantly changed (ME content of male rats was slightly reduced).

Gene_expression (levels) of NT in hypothalamus associated with glutamate, neuropeptide, enkephalin and substance p

13) Confidence 0.15 Published 1981 Journal Regul. Pept. Section Abstract Doc Link 6171018 Disease Relevance 0 Pain Relevance 0.98

Subsequently, Fos may regulate the expression of the NT, ENK, SOM and CRF genes and thus affect the peptidergic efferents from the ACe.

Gene_expression (expression) of NT in ACe

14) Confidence 0.14 Published 1992 Journal Brain Res. Section Abstract Doc Link 1362516 Disease Relevance 0.31 Pain Relevance 0.13

These results provide final evidence that subpopulations of parvocellular PVN neurons can synthesize not only CRH and ENK, but also NT and VIP, in agreement with earlier immunohistochemical results.

Gene_expression (synthesize) of NT in neurons associated with enkephalin

15) Confidence 0.12 Published 1991 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1850078 Disease Relevance 0 Pain Relevance 0.41

Significant elevation in blood CS, ACTH, beta-EP, and NT in the hypothalamus and significant reductions in splenic NKCA and NT in the nucleus accumbens were produced by heat.

Gene_expression (produced) of NT in nucleus accumbens associated with nucleus accumbens

16) Confidence 0.11 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9299063 Disease Relevance 0.16 Pain Relevance 0.13

The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal microdialysis.

Gene_expression (effects) of NT in cortex associated with glutamate and gaba

17) Confidence 0.09 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18721670 Disease Relevance 0 Pain Relevance 0.31

Significant elevation in blood CS, ACTH, beta-EP, and NT in the hypothalamus and significant reductions in splenic NKCA and NT in the nucleus accumbens were produced by heat.

Gene_expression (produced) of NT in nucleus accumbens associated with nucleus accumbens

18) Confidence 0.05 Published 1997 Journal Brain Behav. Immun. Section Abstract Doc Link 9299063 Disease Relevance 0.16 Pain Relevance 0.13

These results suggest that the glucocorticoids may modulate directly the neurotransmitter synthesis of the CRF-, met-ENK, NT-, SOM- and SP-IR cells in the ACe.

Gene_expression (synthesis) of NT in ACe associated with neurotransmitter, somatostatin and substance p

19) Confidence 0.03 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1373477 Disease Relevance 0 Pain Relevance 0.58

The isolated, spontaneously active portal vein of guinea pig was stimulated by the following compounds (the pD2 is given in parentheses): caerulein (CER, 8.02), cholecystokinin octapeptide (CCK-8, 7.59), substance P (SP, 4.68), and carbachol (5.37), whereas neurotensin (NT) was ineffective and angiotensin II (AII) produced inhibition.

Gene_expression (produced) of NT in CER associated with cholecystokinin and substance p

20) Confidence 0.02 Published 1987 Journal Pharmacology Section Abstract Doc Link 2437599 Disease Relevance 0 Pain Relevance 0.26

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