INT81604

Context Info Confidence 0.63 First Reported 1999 Last Reported 2000 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.67 Pain Relevance 0.78

transmembrane transporter activity (SLC22A6) plasma membrane (SLC22A6) protein complex (SLC22A6) transmembrane transport (SLC22A6)

Anatomy Link Frequency renal proximal tubules 1 tubule 1 SLC22A6 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 13 92.08 Potency 3 72.80 Paracetamol 2 58.56

Disease Link Frequency Relevance Heat Nephrotoxicity 2 93.00 INFLAMMATION 4 90.64 Acquired Immune Deficiency Syndrome Or Hiv Infection 4 89.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

It has been recently shown that adefovir is efficiently transported by the human renal organic anion transporter 1 (hOAT1), a membrane transport protein localized in the kidney, that presumably mediates the accumulation of adefovir in renal proximal tubules.

Transcription (transported) of hOAT1 in renal proximal tubules

1) Confidence 0.63 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10991954 Disease Relevance 0.51 Pain Relevance 0.23

Organic anion transporter 1 (OAT1) is the para-aminohippurate (PAH) transporter in the basolateral membrane of the proximal tubule.

Transcription (transporter) of para-aminohippurate in tubule

2) Confidence 0.02 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220563 Disease Relevance 0.17 Pain Relevance 0.55

General Comments

This test has worked.