INT81608

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Context Info
Confidence 0.15
First Reported 1999
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 13
Total Number 13
Disease Relevance 1.58
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Col11a1) cell adhesion (Col11a1) proteinaceous extracellular matrix (Col11a1)
structural molecule activity (Col11a1) molecular_function (Col11a1)
Anatomy Link Frequency
ovary 7
neurons 1
Col11a1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 92 100.00 Very High Very High Very High
mu opioid receptor 24 100.00 Very High Very High Very High
substance P 8 99.32 Very High Very High Very High
addiction 22 98.40 Very High Very High Very High
Morphine 43 98.18 Very High Very High Very High
Opioid 32 97.72 Very High Very High Very High
orphanin 6 97.62 Very High Very High Very High
narcan 32 96.52 Very High Very High Very High
agonist 40 95.04 Very High Very High Very High
Thalamus 3 93.76 High High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 2 99.50 Very High Very High Very High
Targeted Disruption 22 98.74 Very High Very High Very High
Morphine Dependence 12 98.40 Very High Very High Very High
Opiate Addiction 9 98.16 Very High Very High Very High
Pain 17 88.96 High High
Bordatella Infection 8 75.00 Quite High
Hyperalgesia 1 55.92 Quite High
Nociception 5 37.16 Quite Low
Neurodegenerative Disease 48 5.00 Very Low Very Low Very Low
Anxiety Disorder 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using the ligand-stimulated [(35)S]guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) assay, we have found that 10 microM SR141716 slightly but significantly decreases the basal [(35)S]GTPgammaS binding in membranes of the wild-type and CB(1) receptor knockout mouse cortex, parental Chinese hamster ovary (CHO) cells, and CHO cells stably transfected with micro-opioid receptors, MOR-CHO.
Gene_expression (transfected) of MOR-CHO in CHO associated with targeted disruption and opioid receptor
1) Confidence 0.15 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19448142 Disease Relevance 0.17 Pain Relevance 0.42
Using the ligand-stimulated [(35)S]guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) assay, we have found that 10 microM SR141716 slightly but significantly decreases the basal [(35)S]GTPgammaS binding in membranes of the wild-type and CB(1) receptor knockout mouse cortex, parental Chinese hamster ovary (CHO) cells, and CHO cells stably transfected with micro-opioid receptors, MOR-CHO.
Gene_expression (transfected) of CHO in CHO associated with targeted disruption and opioid receptor
2) Confidence 0.15 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19448142 Disease Relevance 0.17 Pain Relevance 0.42
Therefore, IRAS, in the co-transfected CHO-mu/IRAS cell line, appears necessary for low concentrations of agmatine to cause attenuation of cellular morphine dependence.
Gene_expression (transfected) of CHO-mu associated with addiction and morphine
3) Confidence 0.15 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16112088 Disease Relevance 0.35 Pain Relevance 1.30
To investigate the role of imidazoline receptor antisera-selected protein (IRAS), a strong candidate for I1R, in morphine dependence, two CHO cell lines were created, in which mu opioid receptor (MOR) was stably expressed alone (CHO-mu) or MOR and IRAS were stably co-expressed (CHO-mu/IRAS).
Gene_expression (expressed) of CHO-mu associated with addiction, mu opioid receptor and morphine
4) Confidence 0.15 Published 2005 Journal Biochem. Pharmacol. Section Abstract Doc Link 16112088 Disease Relevance 0.35 Pain Relevance 0.95
In vitro, J-113397 inhibited nociceptin/orphanin FQ-stimulated [35S]guanosine 5'-O-(gamma-thio)triphosphate (GTP gamma S) binding to Chinese Hamster Ovary (CHO) cells expressing ORL1 (CHO-ORL1) with an IC(50) value of 5.3 nM but had no effect on [35S]GTP gamma S binding by itself.
Gene_expression (expressing) of CHO-ORL1 in CHO associated with orphanin
5) Confidence 0.02 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10940356 Disease Relevance 0.06 Pain Relevance 0.48
For in vitro transfection, we used a CHO-K1 Tet-On (#C3021-1, Clontech, USA) cell line which was stably transfected with the reverse tetracycline-controlled transactivator (rtTA) driven by the cytomegalovirus promoter. 24 hours post-transfection of the pBI-EYFPBax-TetO-ECFPBax vector, CHO-K1 Tet-On cells (Clontech, USA) grown on PolyLysine (Sigma)-coated coverslips were treated with doxycycline (Dox, 2 µg/ml; #D9891, Sigma, USA), a tetracycline analogue, for 6 hours.
Gene_expression (transfection) of CHO-K1 associated with cytomegalovirus infection
6) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.10 Pain Relevance 0
Here we compared the mu opioid receptor (MOR)-lipid rafts relationship in the rat brain, where neurons have non-caveolae rafts, and in CHO cells stably transfected with HA-rat MOR (CHO-HA-rMOR), which are enriched in caveolae.
Gene_expression (transfected) of CHO-HA-rMOR in neurons associated with mu opioid receptor
7) Confidence 0.01 Published 2007 Journal Brain Res. Section Abstract Doc Link 17980352 Disease Relevance 0 Pain Relevance 0.39
Total RNAs from wild type CHO-K1 cells and the CHO-K1 clone expressing MYC-tagged DOR were isolated with RNAwiz protocol (Ambion).
Gene_expression (expressing) of CHO-K1 associated with opioid receptor
8) Confidence 0.01 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1079869 Disease Relevance 0 Pain Relevance 0.08
The interaction between NaV1.8 and Pdzd2 in the myc-Pdzd2 transfected CHO-SNS22 cells was confirmed by co-immunoprecipitation (Fig. 3C).


Gene_expression (transfected) of CHO-SNS22
9) Confidence 0.01 Published 2009 Journal Mol Cell Neurosci Section Body Doc Link PMC2764382 Disease Relevance 0 Pain Relevance 0.13
Two cell lines, Chinese hamster ovary cells expressing mu opioid receptor alone (CHO-mu) and expressing mu opioid receptor and IRAS together (CHO-mu/IRAS), were used.
Gene_expression (expressing) of CHO-mu in ovary associated with mu opioid receptor
10) Confidence 0.00 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.10 Pain Relevance 0.74
Two cell lines, Chinese hamster ovary cells expressing mu opioid receptor alone (CHO-mu) and expressing mu opioid receptor and IRAS together (CHO-mu/IRAS), were used.
Gene_expression (expressing) of CHO-mu in ovary associated with mu opioid receptor
11) Confidence 0.00 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.10 Pain Relevance 0.76
Two cell lines, Chinese hamster ovary cells expressing mu opioid receptor alone (CHO-mu) and expressing mu opioid receptor and IRAS together (CHO-mu/IRAS), were used.
Gene_expression (expressing) of CHO-mu in ovary associated with mu opioid receptor
12) Confidence 0.00 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16962578 Disease Relevance 0.10 Pain Relevance 0.74
Immunoprecipitation of SPR from 32Pi-labeled Chinese hamster ovary cells stably expressing human SPR (CHO-hSPR) indicates that substance P (SP) causes a rapid (T1/2 < 1 min), dose-dependent (EC50 = 2 nM), and pronounced (5-fold over basal) phosphorylation of SPR.
Gene_expression (expressing) of CHO-hSPR in ovary associated with substance p
13) Confidence 0.00 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.09 Pain Relevance 0.46

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