INT81610

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Context Info
Confidence 0.81
First Reported 1999
Last Reported 1999
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 14
Disease Relevance 0.76
Pain Relevance 8.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TACR1) cytoplasm (TACR1) signal transducer activity (TACR1)
Anatomy Link Frequency
ovary 1
TACR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 112 100.00 Very High Very High Very High
agonist 56 100.00 Very High Very High Very High
Kinase C 70 99.92 Very High Very High Very High
Pain 14 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 14 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these data suggest that although activation of PKC by PMA can lead to SPR phosphorylation, PKC does not mediate SP-dependent phosphorylation of SPR.
Phosphorylation (phosphorylation) of SPR associated with kinase c and substance p
1) Confidence 0.81 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0 Pain Relevance 0.57
Immunoprecipitation of SPR from 32Pi-labeled Chinese hamster ovary cells stably expressing human SPR (CHO-hSPR) indicates that substance P (SP) causes a rapid (T1/2 < 1 min), dose-dependent (EC50 = 2 nM), and pronounced (5-fold over basal) phosphorylation of SPR.
Phosphorylation (phosphorylation) of SPR in ovary associated with substance p
2) Confidence 0.81 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.08 Pain Relevance 0.54
Taken together, these data suggest that although activation of PKC by PMA can lead to SPR phosphorylation, PKC does not mediate SP-dependent phosphorylation of SPR.
Phosphorylation (phosphorylation) of SPR associated with kinase c and substance p
3) Confidence 0.81 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0 Pain Relevance 0.56
Because SPR in CHO-hSPR couples to Galphaq, Galphas, and Galphao (), we examined the involvement of various second messenger-activated protein kinases in SPR phosphorylation.
Phosphorylation (phosphorylation) of SPR
4) Confidence 0.81 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.08 Pain Relevance 0.58
Although increases in intracellular cyclic AMP or treatment with the calcium ionophore A23187 do not cause SPR phosphorylation, treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) causes a 2.5-fold increase in SPR phosphorylation with a T1/2 of <1 min.
Phosphorylation (phosphorylation) of SPR associated with kinase c
5) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.06 Pain Relevance 0.68
Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.
Phosphorylation (phosphorylation) of substance P receptor associated with agonist and substance p
6) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Title Doc Link 10220564 Disease Relevance 0.10 Pain Relevance 0.58
Furthermore, although SP treatment phosphorylates SPR on both serine and threonine residues equally, PMA treatment phosphorylates the receptor predominantly on serine residues.
Phosphorylation (phosphorylates) of SPR associated with substance p
7) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.06 Pain Relevance 0.71
Two-dimensional phosphopeptide mapping data indicate that SP-dependent and PMA-dependent phosphorylations of SPR have some unique differences.
Phosphorylation (phosphorylations) of SPR associated with substance p
8) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0 Pain Relevance 0.63
In conclusion, the present study represents the first demonstration and characterization of agonist-dependent and PMA-mediated phosphorylation of SPR in intact cells.
Phosphorylation (phosphorylation) of SPR associated with agonist
9) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0 Pain Relevance 0.48
Characterization of differences between rapid agonist-dependent phosphorylation and phorbol ester-mediated phosphorylation of human substance P receptor in intact cells.
Phosphorylation (phosphorylation) of substance P receptor associated with agonist and substance p
10) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Title Doc Link 10220564 Disease Relevance 0.10 Pain Relevance 0.58
Although increases in intracellular cyclic AMP or treatment with the calcium ionophore A23187 do not cause SPR phosphorylation, treatment with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) causes a 2.5-fold increase in SPR phosphorylation with a T1/2 of <1 min.
Phosphorylation (phosphorylation) of SPR associated with kinase c
11) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.07 Pain Relevance 0.59
However, PKC inhibitor GF109203X has no effect on SP-dependent SPR phosphorylation.
Phosphorylation (phosphorylation) of SPR associated with kinase c and substance p
12) Confidence 0.71 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.06 Pain Relevance 0.71
The present study shows that human SPR undergoes agonist-dependent phosphorylation in intact cells.
Phosphorylation (phosphorylation) of SPR associated with agonist
13) Confidence 0.54 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.09 Pain Relevance 0.45
Furthermore, although SP treatment phosphorylates SPR on both serine and threonine residues equally, PMA treatment phosphorylates the receptor predominantly on serine residues.
Phosphorylation (phosphorylates) of SPR associated with substance p
14) Confidence 0.54 Published 1999 Journal Mol. Pharmacol. Section Abstract Doc Link 10220564 Disease Relevance 0.06 Pain Relevance 0.72

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