INT81622

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Context Info
Confidence 0.49
First Reported 1998
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.94
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CEL) extracellular space (CEL) small molecule metabolic process (CEL)
extracellular region (CEL) lipid metabolic process (CEL) cytoplasm (CEL)
Anatomy Link Frequency
dendrites 2
plasma 2
NKC 2
endothelium 2
CEL (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 3 97.00 Very High Very High Very High
rheumatoid arthritis 8 95.68 Very High Very High Very High
headache 2 84.00 Quite High
ketamine 1 77.44 Quite High
cINOD 1 75.80 Quite High
Inflammation 3 71.36 Quite High
cytokine 1 38.32 Quite Low
anesthesia 1 25.00 Low Low
Inflammatory response 1 22.32 Low Low
Glutamate 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 100.00 Very High Very High Very High
Experimental Autoimmune Encephalomyelitis 1 99.80 Very High Very High Very High
Apoptosis 39 99.20 Very High Very High Very High
Chronic Fatigue Syndrome 3 98.90 Very High Very High Very High
Injury 2 97.78 Very High Very High Very High
Stress 24 97.44 Very High Very High Very High
Depression 3 97.00 Very High Very High Very High
Rheumatoid Arthritis 8 95.68 Very High Very High Very High
Atherosclerosis 5 92.32 High High
Sleep Disorders 1 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This assay has revealed that plasma calcitonin levels in normal rats are much lower than the detection limits of most existing assays, but can increase by 100-fold on activation of the C-cell Ca2+ receptor.
Positive_regulation (increase) of Positive_regulation (activation) of cell in plasma
1) Confidence 0.49 Published 1998 Journal Endocrine Section Abstract Doc Link 10221596 Disease Relevance 0.23 Pain Relevance 0.04
In fact, immune complexes fixing C1q bind to endothelial receptors, thus triggering an upregulation of adhesion molecules, such as E-selectin and intercellular and vascular cell adhesion molecules 1, on the endothelium surface.
Positive_regulation (triggering) of Positive_regulation (upregulation) of cell in endothelium associated with adhesions
2) Confidence 0.49 Published 2002 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12114307 Disease Relevance 1.47 Pain Relevance 0.41
Depression, psychological stress, tissue injuries, malignancies, carcinogenesis, chronic fatigue syndrome, and experimental allergic encephalomyelitis could be induced at very low physiological concentrations by mycotoxin-induced NKC activity.
Positive_regulation (induced) of Positive_regulation (induced) of NKC in NKC associated with stress, chronic fatigue syndrome, depression, injury and experimental autoimmune encephalomyelitis
3) Confidence 0.49 Published 2003 Journal ScientificWorldJournal Section Abstract Doc Link 14625399 Disease Relevance 1.49 Pain Relevance 0.28
Again, tau inhibits the transport of APP into axons and dendrites, causing its accumulation inthe cell and thus initiates apoptosis - also mediated by caspases 8 and 3 [106, 187].
Positive_regulation (causing) of Positive_regulation (accumulation) of cell in dendrites associated with apoptosis
4) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2647152 Disease Relevance 0.75 Pain Relevance 0

General Comments

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