INT81624

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Context Info
Confidence 0.40
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.30
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefm) cytoskeleton (Nefm)
Anatomy Link Frequency
bladder 2
Nefm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 5 87.12 High High
qutenza 1 86.24 High High
unmyelinated 1 84.56 Quite High
c fibre 1 83.52 Quite High
induced neuropathy 1 38.24 Quite Low
Disease Link Frequency Relevance Heat
Hypertrophy 1 99.76 Very High Very High Very High
Frailty 9 97.88 Very High Very High Very High
Poisoning 1 93.12 High High
Overactive Bladder 3 91.60 High High
Stress Incontinence 1 76.00 Quite High
Abnormal Reflex 2 75.00 Quite High
Neuropathic Pain 1 38.24 Quite Low
Drug Induced Neurotoxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the levels of mRNA expression of NF-H, NF-M, and NF-L genes were elevated consistently in CS(2)-treated groups.
Positive_regulation (elevated) of Gene_expression (expression) of NF-M
1) Confidence 0.40 Published 2006 Journal Neurochem. Res. Section Abstract Doc Link 17120161 Disease Relevance 0.09 Pain Relevance 0.08
Recent electrophysiologic and histologic studies in rats have revealed that chronic SCI induces various phenotypic changes in bladder afferent neurons such as: (1) somal hypertrophy along with increased expression of neurofilament protein; and (2) increased excitability due to the plasticity of Na+ and K+ ion channels.
Positive_regulation (increased) of Gene_expression (expression) of neurofilament protein in bladder associated with hypertrophy and frailty
2) Confidence 0.14 Published 1999 Journal Prog. Neurobiol. Section Abstract Doc Link 10221783 Disease Relevance 1.21 Pain Relevance 0.29

General Comments

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