INT81626

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 34
Total Number 36
Disease Relevance 16.75
Pain Relevance 12.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Anatomy Link Frequency
neurons 6
EL4 4
colon 2
CLC 2
apoptotic cell 2
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 69 100.00 Very High Very High Very High
Clonidine 6 100.00 Very High Very High Very High
qutenza 10 99.98 Very High Very High Very High
Dynorphin 23 99.92 Very High Very High Very High
Endogenous opioid 4 99.00 Very High Very High Very High
cINOD 28 98.62 Very High Very High Very High
Neuropeptide 5 98.28 Very High Very High Very High
antagonist 13 97.80 Very High Very High Very High
midbrain 3 97.52 Very High Very High Very High
Opioid 5 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 715 100.00 Very High Very High Very High
Death 232 99.98 Very High Very High Very High
Colon Cancer 9 99.80 Very High Very High Very High
Pancreatic Cancer 62 99.48 Very High Very High Very High
Cancer 567 99.04 Very High Very High Very High
Lymphatic System Cancer 16 98.48 Very High Very High Very High
Targeted Disruption 24 98.36 Very High Very High Very High
Stress 106 98.20 Very High Very High Very High
Middle Cerebral Artery Infarction 33 97.48 Very High Very High Very High
Frailty 7 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By promoting caspase-3 activation, dynorphin peptides likely increase the probability of glial apoptosis after SCI.
Positive_regulation (promoting) of Positive_regulation (activation) of caspase-3 associated with dynorphin, frailty and apoptosis
1) Confidence 0.69 Published 2007 Journal Neuroscience Section Abstract Doc Link 17698296 Disease Relevance 0.81 Pain Relevance 0.31
In conclusion, our findings indicate that estradiol has a facilitating effect on morphine reward while its deficiency increases the threshold dose of morphine to induce CPP.
Positive_regulation (increases) of Positive_regulation (induce) of CPP associated with morphine
2) Confidence 0.60 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19463255 Disease Relevance 0 Pain Relevance 0.51
Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation.
Positive_regulation (receptor-mediated) of Positive_regulation (activation) of caspase-3 in neurons associated with dynorphin and apoptosis
3) Confidence 0.50 Published 2003 Journal Neuroscience Section Title Doc Link 14643768 Disease Relevance 0.47 Pain Relevance 0.77
Cell death (activated caspase-3 counts) was increased after 24 but not 96 h.
Neg (not) Positive_regulation (increased) of Positive_regulation (activated) of caspase-3 associated with death
4) Confidence 0.49 Published 2008 Journal Neuroscience Section Abstract Doc Link 18832014 Disease Relevance 0.36 Pain Relevance 0.87
Treatment with darbufelone also induced apoptosis by activating caspase-3 and caspase-8.
Positive_regulation (induced) of Positive_regulation (activating) of caspase-3
5) Confidence 0.49 Published 2010 Journal Cancer Chemother. Pharmacol. Section Body Doc Link 20352217 Disease Relevance 0.16 Pain Relevance 0
The results show that dynorphin A (1-17) (>or=10 nM) caused concentration-dependent increases in caspase-3 activity that were accompanied by mitochondrial release of cytochrome c and the subsequent death of cultured mouse striatal neurons.
Positive_regulation (caused) of Positive_regulation (increases) of caspase-3 in neurons associated with dynorphin and death
6) Confidence 0.46 Published 2003 Journal Neuroscience Section Abstract Doc Link 14643768 Disease Relevance 0.62 Pain Relevance 0.88
Interestingly, DP thymocyte depletion inside TNCs is dependent on androgens, and the intracellular thymocyte pathway of cell death leads to activation of caspase-3 [28].
Positive_regulation (leads) of Positive_regulation (activation) of caspase-3 in thymocyte associated with death
7) Confidence 0.45 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.00 Pain Relevance 0.04
Treatment of B16-F10 cells with capsaicin caused release of mitochondrial cytochrome c, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase in a dose-dependent manner.
Positive_regulation (caused) of Positive_regulation (activation) of caspase-3 in B16-F10 associated with qutenza
8) Confidence 0.44 Published 2007 Journal Food Chem. Toxicol. Section Abstract Doc Link 17306913 Disease Relevance 0.32 Pain Relevance 0.76
Yohimbine increased, while clonidine and prazosin reversed, morphine-induced CPP.
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine and clonidine
9) Confidence 0.41 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.25
Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
Neg (not) Positive_regulation (change) of Positive_regulation (induced) of CPP associated with morphine
10) Confidence 0.41 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16182480 Disease Relevance 0 Pain Relevance 0.66
The main finding was that all doses of scopolamine enhanced the extinction of morphine-induced CPP in mice treated with morphine for 12 days.
Positive_regulation (enhanced) of Positive_regulation (induced) of CPP associated with morphine
11) Confidence 0.40 Published 2007 Journal Addict Biol Section Abstract Doc Link 17678506 Disease Relevance 0 Pain Relevance 0.87
Furthermore, a high concentration of BPA markedly induced the activation of caspase-3, which is a marker of neuronal apoptotic cell death in mouse midbrain neurone/glia cocultures.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 in apoptotic cell associated with midbrain, apoptosis and death
12) Confidence 0.35 Published 2006 Journal J. Neuroendocrinol. Section Abstract Doc Link 16684133 Disease Relevance 0.20 Pain Relevance 0.32
Significantly elevated activities of caspase-3, caspase-8 and caspase-9 were observed in BJMC3879luc2 cells treated with raloxifene for 24 h (Figure 2B) and 48 h (data not shown), as compared to the respective controls.
Positive_regulation (elevated) of Positive_regulation (activities) of caspase-3
13) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.45 Pain Relevance 0
In contrast, injection of the anti-Fas antibody Jo-2 (positive control) caused a 28-fold increase of caspase-3 activity and severe DNA fragmentation before significant ALT release.
Positive_regulation (caused) of Positive_regulation (increase) of caspase-3
14) Confidence 0.33 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10222310 Disease Relevance 0.82 Pain Relevance 0.85
We observed microglial activation (Figure 1j) and caspase 3 activation (Figure 1k) in the corticospinal tract (CST) contralateral to MCAo, further suggesting the presence of an injury upstream to ventral horn motor neurons.
Positive_regulation (activation) of Positive_regulation (activation) of caspase 3 in horn associated with middle cerebral artery infarction and injury
15) Confidence 0.28 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2474603 Disease Relevance 0.37 Pain Relevance 0.03
Conclusion: The decreased rate of apoptosis in the knockout mice correlated with an almost undetectable and significantly decreased level of activated caspase-3 and significantly increased levels of X-linked inhibitor of apoptosis protein, which also correlated with increased levels of nuclear factor kappa B p52 and decreased levels of c-Jun N-terminal kinase; this provides a possible mechanism for the decrease in apoptosis seen in CXCR2 knockout mice.
Positive_regulation (increased) of Positive_regulation (activated) of caspase-3 associated with targeted disruption and apoptosis
16) Confidence 0.26 Published 2010 Journal Hepatology Section Abstract Doc Link 20683965 Disease Relevance 1.44 Pain Relevance 0.52
Chemotherapy induced dose-dependent caspase-3 activation and PARP-1 cleavage in tumors of EL4 lymphoma-bearing mice (Figure 3).
Positive_regulation (dependent) of Positive_regulation (activation) of caspase-3 in EL4 associated with lymphatic system cancer and cancer
17) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.50 Pain Relevance 0.04
Chemotherapy induced dose-dependent caspase-3 activation and PARP-1 cleavage in tumors of EL4 lymphoma-bearing mice (Figure 3).
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 in EL4 associated with lymphatic system cancer and cancer
18) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.51 Pain Relevance 0.04
In contrast, after application of prazosin or yohimbine, the expression of morphine-induced CPP was increased.
Positive_regulation (increased) of Positive_regulation (induced) of CPP associated with morphine
19) Confidence 0.23 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.43
The MPP+ treatment induced the activation of caspase-3 in TSM1 neurons up to 233.9% as compared to the untreated control of active caspase-3 content of TSM1 cells.
Positive_regulation (induced) of Positive_regulation (activation) of caspase-3 in neurons
20) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0 Pain Relevance 0

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