INT81627

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Context Info
Confidence 0.78
First Reported 1999
Last Reported 2011
Negated 1
Speculated 3
Reported most in Abstract
Documents 120
Total Number 123
Disease Relevance 115.51
Pain Relevance 15.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
T cells 14
brain 11
liver 6
apoptotic cells 4
synovium 4
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 906 100.00 Very High Very High Very High
agonist 64 100.00 Very High Very High Very High
rheumatoid arthritis 755 99.84 Very High Very High Very High
Paracetamol 47 99.70 Very High Very High Very High
Opioid 14 99.22 Very High Very High Very High
palliative 5 99.16 Very High Very High Very High
diclofenac 9 99.12 Very High Very High Very High
withdrawal 38 98.52 Very High Very High Very High
cytokine 651 98.30 Very High Very High Very High
Endogenous opioid 4 98.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 4504 100.00 Very High Very High Very High
Death 1436 100.00 Very High Very High Very High
INFLAMMATION 1045 100.00 Very High Very High Very High
Cancer 874 100.00 Very High Very High Very High
Adhesions 155 100.00 Very High Very High Very High
Necrosis 129 100.00 Very High Very High Very High
Neurodegenerative Disease 246 99.86 Very High Very High Very High
Disease 1255 99.84 Very High Very High Very High
Rheumatoid Arthritis 759 99.84 Very High Very High Very High
Targeted Disruption 295 99.78 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A peak incidence of TUNEL positive cells was found in the injured cortex at 24 hours which remained slightly elevated at 7 days and coincided with maximum Fas expression.
Gene_expression (expression) of Fas in cortex
1) Confidence 0.78 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 1.30 Pain Relevance 0.22
Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: relationship with neuronal cell death and inflammatory mediators.
Gene_expression (expression) of Fas in brain associated with inflammatory mediators and death
2) Confidence 0.78 Published 2007 Journal Histol. Histopathol. Section Title Doc Link 17163398 Disease Relevance 1.32 Pain Relevance 0.22
To do this, we have developed a chemically modified 2'-O-(2-methoxy)ethyl antisense oligonucleotide (ISIS 22023) inhibitor of mouse Fas expression.
Gene_expression (expression) of Fas
3) Confidence 0.77 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.66 Pain Relevance 0
In addition, oligonucleotide-mediated suppression of Fas expression reduced the severity of acetaminophen-mediated fulminant hepatitis, but was without effect on concanavalin A-mediated hepatitis.
Gene_expression (expression) of Fas associated with paracetamol and hepatitis
4) Confidence 0.77 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.72 Pain Relevance 0.10
Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis.
Gene_expression (expression) of Fas in liver associated with hepatitis
5) Confidence 0.77 Published 2000 Journal Nat. Biotechnol. Section Title Doc Link 10932156 Disease Relevance 0.71 Pain Relevance 0
We have explored the possibility that inhibition of Fas expression in mice would reduce the severity of fulminant hepatitis.
Gene_expression (expression) of Fas associated with hepatitis
6) Confidence 0.77 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.64 Pain Relevance 0
Using a pancreatic duct epithelial cell line MRL/S-1 newly established from the MRL/gld mouse that lacks FasL, we showed that treatment with poly I:C significantly induced the expression of Fas on the cultured cells.
Gene_expression (expression) of Fas in poly
7) Confidence 0.75 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.38 Pain Relevance 0.21
Here, we found that BMMSCs are akin to osteoblasts expressing Fas.
Gene_expression (expressing) of Fas in osteoblasts
8) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 1.17 Pain Relevance 0.03
It has been reported that osteoblasts express Fas and the FasL/Fas pathway involved in osteogenic cell apoptosis in response to glucocorticoids [39].
Gene_expression (express) of Fas in osteoblasts associated with apoptosis
9) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 1.18 Pain Relevance 0.03
It has been reported that osteoblasts express Fas and the FasL/Fas pathway involved in osteogenic cell apoptosis in response to glucocorticoids [39].
Gene_expression (express) of Fas in osteoblasts associated with apoptosis
10) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 1.19 Pain Relevance 0.03
The results suggest that mu-receptors tonically stimulate (through endogenous opioid peptides) the activation of native Fas, whereas delta-receptors tonically inhibit the expression of Fas aggregates and that of FADD and phosphorylated FADD (Ser191) in the mouse brain.
Gene_expression (expression) of Fas in brain associated with endogenous opioid
11) Confidence 0.75 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.16 Pain Relevance 0.59
Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: relationship with neuronal cell death and inflammatory mediators.
Gene_expression (expression) of Fas in brain associated with inflammatory mediators and death
12) Confidence 0.67 Published 2007 Journal Histol. Histopathol. Section Title Doc Link 17163398 Disease Relevance 1.32 Pain Relevance 0.22
Immunohistochemical characterization of Fas (CD95) and Fas Ligand (FasL/CD95L) expression in the injured brain: relationship with neuronal cell death and inflammatory mediators.
Gene_expression (expression) of CD95 in brain associated with inflammatory mediators and death
13) Confidence 0.67 Published 2007 Journal Histol. Histopathol. Section Title Doc Link 17163398 Disease Relevance 1.32 Pain Relevance 0.22
Consecutive brain sections were evaluated for Fas and FasL expression, in situ DNA fragmentation (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling; TUNEL), morphologic characteristics of apoptotic cell death and leukocyte infiltration.
Gene_expression (expression) of Fas in apoptotic cell associated with apoptosis and death
14) Confidence 0.67 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 1.45 Pain Relevance 0.23
In Balb/c mice, dosing with ISIS 22023 reduced Fas mRNA and protein expressions in liver by 90%.
Gene_expression (expressions) of Fas in liver
15) Confidence 0.67 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.74 Pain Relevance 0.06
In tissue culture, this oligonucleotide induced a reduction in Fas mRNA expression that was both concentration- and sequence-specific.
Gene_expression (expression) of Fas
16) Confidence 0.67 Published 2000 Journal Nat. Biotechnol. Section Abstract Doc Link 10932156 Disease Relevance 0.65 Pain Relevance 0
For example, because loss of one allele of Bim synergizes with Fas deficiency to cause immunopathology, it is possible that combinations of mutant alleles of Bim and Fas, which by themselves do not cause readily identifiable abnormalities, may underlie certain autoimmune diseases in humans.
Gene_expression (synergizes) of Fas associated with autoimmune disease and congenital anomalies
17) Confidence 0.66 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.85 Pain Relevance 0
Faslpr/lpr and Bcl2l11+/?
Gene_expression (/) of lpr
18) Confidence 0.66 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.53 Pain Relevance 0.04
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Gene_expression (activation) of Fas in T cells associated with death
19) Confidence 0.66 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.32 Pain Relevance 0
Some studies showed that deletion of SEB-activated T cells in mice was in part FasL-Fas dependent (Mogil et al., 1995; Renno et al., 1996), whereas others found that Fas deficiency (in Faslpr/lpr mutant mice) had no impact but that loss of Bim provided profound protection (Hildeman et al., 2002).
Gene_expression (deficiency) of Fas in T cells
20) Confidence 0.66 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.30 Pain Relevance 0

General Comments

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