INT81628

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Context Info
Confidence 0.67
First Reported 1999
Last Reported 2011
Negated 1
Speculated 2
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 38.13
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
T cells 12
apoptotic cell 6
brain 4
livers 2
cleavage 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 308 100.00 Very High Very High Very High
Paracetamol 13 99.40 Very High Very High Very High
agonist 6 98.52 Very High Very High Very High
cytokine 338 98.30 Very High Very High Very High
dopaminergic neurodegeneration 1 97.08 Very High Very High Very High
Inflammatory response 36 97.04 Very High Very High Very High
COX-2 inhibitor 3 95.28 Very High Very High Very High
Arthritis 53 94.64 High High
metalloproteinase 8 93.48 High High
Inflammatory mediators 21 88.64 High High
Disease Link Frequency Relevance Heat
Apoptosis 1623 100.00 Very High Very High Very High
INFLAMMATION 377 100.00 Very High Very High Very High
Cancer 189 100.00 Very High Very High Very High
Necrosis 49 100.00 Very High Very High Very High
Adhesions 36 100.00 Very High Very High Very High
Death 508 99.96 Very High Very High Very High
Neurodegenerative Disease 87 99.86 Very High Very High Very High
Spinal Cord Injury 122 99.80 Very High Very High Very High
Disease 476 99.64 Very High Very High Very High
Infection 470 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a pancreatic duct epithelial cell line MRL/S-1 newly established from the MRL/gld mouse that lacks FasL, we showed that treatment with poly I:C significantly induced the expression of Fas on the cultured cells.
Positive_regulation (induced) of Gene_expression (expression) of Fas in poly
1) Confidence 0.67 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.38 Pain Relevance 0.21
Occasionally in vitro exposure of lymphoma cells to non specific bacterial Sags induced a slight but not significant increase in the expression of Fas (Figure 5E).
Neg (not) Positive_regulation (increase) of Gene_expression (expression) of Fas associated with lymphatic system cancer
2) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.15 Pain Relevance 0
Contrarily, a marked increase in the expression of Fas and in the percentage of Fas-L positive neoplastic cells was recorded when cells were cultured with specific Sags (Figure 5B-E).
Positive_regulation (increase) of Gene_expression (expression) of Fas
3) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.52 Pain Relevance 0
Consecutive brain sections were evaluated for Fas and FasL expression, in situ DNA fragmentation (terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling; TUNEL), morphologic characteristics of apoptotic cell death and leukocyte infiltration.
Positive_regulation (evaluated) of Gene_expression (expression) of Fas in apoptotic cell associated with apoptosis and death
4) Confidence 0.50 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 1.46 Pain Relevance 0.24
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (requires) of Gene_expression (activation) of Fas in T cells associated with death
5) Confidence 0.49 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.33 Pain Relevance 0
In contrast, injection of the anti-Fas antibody Jo-2 (positive control) caused a 28-fold increase of caspase-3 activity and severe DNA fragmentation before significant ALT release.
Positive_regulation (caused) of Gene_expression (injection) of Fas
6) Confidence 0.49 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 10222310 Disease Relevance 0.82 Pain Relevance 0.81
These findings suggest, but do not prove, an involvement of the alternative pathway of complement activation in regulating neuronal apoptosis after TBI by suppression of Bcl-2 and induction of Fas receptor expression in the injured brain.
Positive_regulation (induction) of Gene_expression (expression) of Fas in brain associated with neurodegenerative disease and brain injury
7) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 1.03 Pain Relevance 0.06
The expression of Fas, FasL and caspase 3 mRNA was increased in infected livers.
Positive_regulation (increased) of Gene_expression (expression) of Fas in livers
8) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 2.00 Pain Relevance 0.09
Fas expression was increased in the superficial epidermis of active samples whereas, in healing and healthy patients, Fas was not increased.
Positive_regulation (increased) of Gene_expression (expression) of Fas in epidermis
9) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.54 Pain Relevance 0
Fas and FasL expression was increased in the eyes of infected wild-type mice compared to non infected mice [47].
Positive_regulation (increased) of Gene_expression (expression) of Fas in eyes
10) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.77 Pain Relevance 0.15
Increased expression of the gene encoding the pro-apoptosis receptor Fas and genes downstream of Fas signalling, as well as genes linked to the TNF receptor pathways, were detected.
Positive_regulation (Increased) of Gene_expression (expression) of Fas associated with apoptosis
11) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.75 Pain Relevance 0.03
Expression of Fas/FasL was enhanced in the brain, 28 days after inoculation of wild-type mice with Toxoplasma gondii.
Positive_regulation (enhanced) of Gene_expression (Expression) of Fas in brain
12) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.75 Pain Relevance 0.05
These results show that bacterial Sags upregulate the expression of Fas and Fas-L on lymphoma T cells expressing the appropriate TCR V?
Positive_regulation (upregulate) of Gene_expression (expression) of Fas in T cells associated with lymphatic system cancer
13) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.91 Pain Relevance 0
In order to study whether Sags were able to induce increases in Fas and Fas-L expression in vivo, CFSE-stained T5 and T8 lymphoma cells were intraperitoneally inoculated and 1 hour later mice received SEE, SEI, SEB or PBS.
Positive_regulation (increases) of Gene_expression (expression) of Fas associated with lymphatic system cancer
14) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.08 Pain Relevance 0
One to three days later, cognate lymphoma cells exhibited significantly higher expression levels of Fas; the percentage of Fas-L positive cells was also significantly increased.
Positive_regulation (increased) of Gene_expression (expression) of Fas associated with lymphatic system cancer
15) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 0.90 Pain Relevance 0
SCI leads to increased expression of Fas and FasL, which results in the continued activation of microglia and the inflammatory response, inducing a cascade of apoptotic cell death and extension of the initial damage [67].
Positive_regulation (increased) of Gene_expression (expression) of Fas in apoptotic cell associated with inflammatory response, spinal cord injury, apoptosis and death
16) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 1.90 Pain Relevance 0.17
Histopathological examination showed centrilobular hepatic necrosis with leukocyte infiltration and a large number of apoptotic hepatocytes 10 and 24 h after APAP challenge. mRNA expression of intercellular adhesion molecule 1, vascular cell adhesion molecule 1, interleukin (IL) 1alpha, IL-1beta, IL-6, tumor necrosis factor alpha, monocyte chemoattractant protein 1, macrophage inflammatory protein (MIP) 1alpha, MIP-2, KC, IP-10, Mig, Fas, and inducible nitric oxide synthase was enhanced in the liver of wild-type mice injected with APAP.
Positive_regulation (enhanced) of Gene_expression (expression) of Fas in monocyte associated with necrosis, inflammation, cancer, apoptosis and adhesions
17) Confidence 0.32 Published 2002 Journal FASEB J. Section Abstract Doc Link 12153990 Disease Relevance 0.98 Pain Relevance 0.21
Sham-operated control mice (n = 6 per gene and time-point) showed a non-significant increase in the expression of Bcl-2, C1-Inh, and Fas at each time point assessed („sham“ group, n = 6 per gene and time-point, Fig. 7).
Positive_regulation (increase) of Gene_expression (expression) of Fas associated with apoptosis
18) Confidence 0.30 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC1867808 Disease Relevance 0.90 Pain Relevance 0
Apoptosis is induced by Fas and FasL protein expression, leading to caspase activation and cleavage of structural target proteins.
Positive_regulation (induced) of Gene_expression (expression) of Fas in cleavage associated with apoptosis
19) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.42 Pain Relevance 0.08
Increased expression of the gene encoding the pro-apoptosis receptor Fas and genes downstream of Fas signalling, as well as genes linked to the TNF receptor pathways, were detected.
Positive_regulation (Increased) of Gene_expression (expression) of Fas associated with apoptosis
20) Confidence 0.29 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.69 Pain Relevance 0.03

General Comments

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