INT81629

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Context Info
Confidence 0.70
First Reported 1999
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 58
Total Number 60
Disease Relevance 59.63
Pain Relevance 12.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
T cells 5
brain 3
lymphocyte 2
cortex 2
synovium 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
Demyelination 39 99.92 Very High Very High Very High
Endogenous opioid 6 99.70 Very High Very High Very High
cytokine 397 99.64 Very High Very High Very High
rheumatoid arthritis 617 99.28 Very High Very High Very High
Paracetamol 34 99.28 Very High Very High Very High
opiate 9 99.28 Very High Very High Very High
Inflammation 510 99.16 Very High Very High Very High
diclofenac 9 99.12 Very High Very High Very High
agonist 5 99.00 Very High Very High Very High
tetrodotoxin 1 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 1883 100.00 Very High Very High Very High
Death 724 100.00 Very High Very High Very High
Adhesions 71 100.00 Very High Very High Very High
Demyelinating Disease 56 99.92 Very High Very High Very High
Liver Failure 8 99.92 Very High Very High Very High
Farber Lipogranulomatosis 123 99.88 Very High Very High Very High
Severe Combined Immunodeficiency 263 99.64 Very High Very High Very High
Infection 421 99.60 Very High Very High Very High
Suicidal Behaviour 27 99.60 Very High Very High Very High
Toxicity 82 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, Fas and FasL upregulation seems to be independent of neuroinflammation since no differences were found between cytokine-/- and wild-type mice.
Positive_regulation (upregulation) of Fas associated with cytokine
1) Confidence 0.70 Published 2007 Journal Histol. Histopathol. Section Abstract Doc Link 17163398 Disease Relevance 0.83 Pain Relevance 0.18
MHC class I proteins were induced in electrically silenced murine hippocampal neurons by treatment with the sodium channel blocker tetrodotoxin and recombinant IFN-gamma, conditions which also resulted in the induction of Fas molecules.
Positive_regulation (induction) of Fas in neurons associated with tetrodotoxin and sodium channel
2) Confidence 0.67 Published 2000 Journal Eur. J. Immunol. Section Abstract Doc Link 11169405 Disease Relevance 0.17 Pain Relevance 0.27
These data are in line with the acute opposite modulation of Fas and FADD induced by mu- and delta-opiate agonists, and strongly support the notion of an anti-apoptotic delta-opioid tone that restrains Fas signaling.
Positive_regulation (induced) of Fas associated with agonist, opiate, apoptosis and opioid
3) Confidence 0.67 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.25 Pain Relevance 0.56
These effects were associated with up-regulation of pro-apoptotic proteins such as Fas, FasL and Bad, in the cortex and hippocampus, indicating the activation of both the death receptor and the mitochondrial apoptotic pathways.
Positive_regulation (up-regulation) of Fas in hippocampus associated with hippocampus, apoptosis and death
4) Confidence 0.61 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18201731 Disease Relevance 0.80 Pain Relevance 0.12
-induced CD95 (Fas) upregulation, and diminished cytolytic activity, but to a significant increase in anti-dsDNA antibodies [70].
Positive_regulation (upregulation) of CD95
5) Confidence 0.60 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374473 Disease Relevance 0.77 Pain Relevance 0.12
Because it has been reported that opioids, via a direct interaction, sensitize splenocytes to Fas-mediated apoptosis by upregulating Fas messenger RNA (mRNA) and modulated neutrophil activity, we assumed that opioids may participate in the pathophysiology of hepatitis.
Positive_regulation (upregulating) of Fas in neutrophil associated with apoptosis, opioid and hepatitis
6) Confidence 0.59 Published 2004 Journal Hepatology Section Abstract Doc Link 15389866 Disease Relevance 0.62 Pain Relevance 0.52
FasL and Fas have been implicated because activation-induced cell death (AICD), an in vitro model in which mitogen-activated T cell blasts are killed by TCR restimulation, which causes FasL upregulation, is inhibited by FasL or Fas inactivation (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Positive_regulation (inactivation) of Fas in T cell associated with death
7) Confidence 0.49 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.89 Pain Relevance 0.04
These findings indicate that TLR3 signaling generates the Fas/FasL-mediated cytotoxicity, thereby leading to the development of chronic pancreatitis.
Positive_regulation (mediated) of Fas associated with chronic pancreatitis
8) Confidence 0.49 Published 2009 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 19282652 Disease Relevance 0.29 Pain Relevance 0.26
The results suggest that mu-receptors tonically stimulate (through endogenous opioid peptides) the activation of native Fas, whereas delta-receptors tonically inhibit the expression of Fas aggregates and that of FADD and phosphorylated FADD (Ser191) in the mouse brain.
Positive_regulation (activation) of Fas in brain associated with endogenous opioid
9) Confidence 0.48 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.16 Pain Relevance 0.64
In delta-KO mice, but not in mu- or kappa-KO mice, the basal content of 120 kDa Fas aggregates (complexes of monomers relevant in Fas signaling) was markedly increased in the cortex (93%).
Neg (not) Positive_regulation (increased) of Fas in cortex
10) Confidence 0.48 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17030115 Disease Relevance 0.31 Pain Relevance 0.58
These results demonstrate that Fas activation, which requires repeated TCR stimulation to upregulate FasL in T cells, is not involved in the shutdown of acute immune responses; instead, this death is mediated predominantly by Bim.


Positive_regulation (activation) of Fas in T cells associated with death
11) Confidence 0.46 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 1.32 Pain Relevance 0
Although the importance of Fas and Bim in lymphocyte homeostasis is widely accepted, their respective roles in immune response shutdown remain controversial (Hildeman et al., 2002; Krammer, 2000; Sprent and Tough, 2001).
Positive_regulation (importance) of Fas in lymphocyte
12) Confidence 0.46 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.65 Pain Relevance 0.07
Inhibition of Fas receptor (CD95)-induced hepatic caspase activation and apoptosis by acetaminophen in mice.
Positive_regulation (activation) of CD95 associated with paracetamol and apoptosis
13) Confidence 0.45 Published 1999 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 10222310 Disease Relevance 0.71 Pain Relevance 0.61
Six hours after AAP administration to BALB/c mice, a significant loss of hepatic mitochondrial cytochrome c was observed that was similar in extent to the loss observed after in vivo activation of CD95 by antibody treatment.
Positive_regulation (activation) of CD95 associated with paracetamol
14) Confidence 0.43 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12946648 Disease Relevance 0.33 Pain Relevance 0.53
This neurotoxic effect was accompanied by up-regulation of the proapoptotic proteins FasL, Fas, and Bad and the active fragments of caspases-8 and -3 in cortical and hippocampal lysates.
Positive_regulation (up-regulation) of Fas
15) Confidence 0.43 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.50 Pain Relevance 0.59
Macrophage-mediate demyelination is dependent on Fas-ligand (FasL)-mediated Schwann cell death.


Positive_regulation (dependent) of Fas in Schwann cell associated with demyelination and death
16) Confidence 0.42 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2743195 Disease Relevance 1.93 Pain Relevance 0.24
Fas expression was increased in the superficial epidermis of active samples whereas, in healing and healthy patients, Fas was not increased.
Neg (not) Positive_regulation (increased) of Fas in epidermis
17) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.50 Pain Relevance 0
It was demonstrated later that an increase in the level of Fas-FasL regulates the extent of cardiac inflammation, cardiomyocytes destruction and heart failure in Chagas disease patients [19,20].
Positive_regulation (increase) of Fas in heart associated with inflammation, american trypanosomiasis and myocardial infarction
18) Confidence 0.41 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2995786 Disease Relevance 1.94 Pain Relevance 0.13
MRL/lpr mice were generated by the insertion of the early transposable element ETn in the Fas gene, which causes a striking reduction in Fas mRNA expression and is associated clinically with marked acceleration of the lupus-like disease [39].
Positive_regulation (generated) of MRL/lpr associated with disease and systemic lupus erythematosus
19) Confidence 0.38 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2873699 Disease Relevance 1.27 Pain Relevance 0
The resulting F1 offspring were screened for lpr (according to Jackson Laboratory instructions) and Tg+ (as described above) status, and Tg+ lpr heterozygous mice were bred.
Positive_regulation (screened) of lpr associated with targeted disruption
20) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.30 Pain Relevance 0

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