INT81640

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Context Info
Confidence 0.69
First Reported 1999
Last Reported 2010
Negated 5
Speculated 0
Reported most in Body
Documents 106
Total Number 109
Disease Relevance 84.58
Pain Relevance 11.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
MDA-MB-453 10
B-cell 8
neuronal 6
cardiac muscle 4
bar 4
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
withdrawal 40 99.84 Very High Very High Very High
Paracetamol 67 99.68 Very High Very High Very High
qutenza 24 99.48 Very High Very High Very High
antagonist 39 99.02 Very High Very High Very High
dexamethasone 240 98.52 Very High Very High Very High
Hippocampus 23 98.28 Very High Very High Very High
cva 41 97.84 Very High Very High Very High
Chronic pancreatitis 4 97.12 Very High Very High Very High
COX-2 inhibitor 121 95.76 Very High Very High Very High
Arthritis 73 95.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 3549 100.00 Very High Very High Very High
Lymphatic System Cancer 392 100.00 Very High Very High Very High
Targeted Disruption 206 100.00 Very High Very High Very High
Disease 777 99.92 Very High Very High Very High
Cancer 1998 99.86 Very High Very High Very High
Mycosis Fungoides 18 99.84 Very High Very High Very High
Hepatotoxicity 27 99.80 Very High Very High Very High
Breast Cancer 478 99.68 Very High Very High Very High
Injury 302 99.64 Very High Very High Very High
Nasopharynx Cancer 12 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transfection of the bcl-2 gene into MDA-MB-453 cells decreased their sensitivity to DOX and MMC but not to taxanes such as TXL and TXT.
Positive_regulation (Transfection) of Gene_expression (Transfection) of bcl-2 in MDA-MB-453
1) Confidence 0.69 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.44 Pain Relevance 0
Bcl-2 expression is regulated by the ER-responsive element of the promoter region of the bcl-2 gene [26], such that overexpression of Bcl-2 might be expected to confer greater drug resistance on ER-positive breast cancer cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with breast cancer
2) Confidence 0.69 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.66 Pain Relevance 0
Several studies indicate that overexpression of Bcl-2 inhibits apoptosis induced by anticancer drugs, radiation, and other DNA-damaging agents [9,10].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with apoptosis
3) Confidence 0.69 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.94 Pain Relevance 0
Because the enforced overexpression of Bcl-2 can act as an antioxidant in response to DNA damage, the decreased chemosensitivity of the Bcl-2-transfected breast cancer cells to DNA-damaging agents, including DOX and MMC, may be explained by this effect.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with breast cancer
4) Confidence 0.69 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.39 Pain Relevance 0
In conclusion, these data suggest for the first time that BAX may be an early determinant of APAP-mediated hepatotoxicity and that BCL-2 overexpression unexpectedly enhances APAP hepatotoxicity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BCL-2 associated with paracetamol and hepatotoxicity
5) Confidence 0.66 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641418 Disease Relevance 0.83 Pain Relevance 0.74
Based on the antiapoptotic characteristics of BCL-2, we further hypothesized that if a BAX component was evident then BCL-2 overexpression may be hepatoprotective.
Positive_regulation (overexpression) of Gene_expression (overexpression) of BCL-2
6) Confidence 0.66 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11641418 Disease Relevance 0.67 Pain Relevance 0.75
Enhanced acetaminophen hepatotoxicity in transgenic mice overexpressing BCL-2.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of BCL-2 associated with targeted disruption, paracetamol and hepatotoxicity
7) Confidence 0.66 Published 2001 Journal Mol. Pharmacol. Section Title Doc Link 11641418 Disease Relevance 0.81 Pain Relevance 0.83
APAP administration upregulated Cox-2 and B-cell lymphoma-2 (Bcl-2) production and had an effect, albeit minor, on Cox-1 and Fas expression in hepatic tissue.
Positive_regulation (upregulated) of Gene_expression (production) of Bcl-2 in B-cell associated with paracetamol and lymphatic system cancer
8) Confidence 0.58 Published 2008 Journal Dig. Dis. Sci. Section Abstract Doc Link 18373199 Disease Relevance 0.54 Pain Relevance 0.84
As shown in Figures 5/6, PADMA 28-mediated induction of apoptosis was diminished (Figure 5, bar 6 and 8) by transient overexpression of Bcl-2 in a CEM cell sub-line in which expression of the corresponding trans-gene was induced by withdrawal of doxocycline (Bujard system, CEM C7H2 Bcl-2 TET off).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 in bar associated with apoptosis and withdrawal
9) Confidence 0.53 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.34 Pain Relevance 0.09
If PADMA 28 triggers apoptosis by interfering with pro-survival Bcl-2 signalling, it should be possible to diminish the pro-apoptotic signal by overexpression of Bcl-2.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with apoptosis
10) Confidence 0.53 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.36 Pain Relevance 0.08
In fact, overexpression of Bcl-2 and Bcl-xL is observed in several cancers, including hematologic malignancies, as well as a range of solid tumors, including nasopharyngeal, colorectal, prostate, and breast cancer [5-7].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with cancer, breast cancer, solid tumor and hematologic neoplasms
11) Confidence 0.50 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.87 Pain Relevance 0
Two other clones transfected with the bcl-2 gene had similar drug sensitivities to those of control cells transfected with vector alone (data not shown).


Positive_regulation (transfected) of Gene_expression (transfected) of bcl-2
12) Confidence 0.50 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.24 Pain Relevance 0
Given that Bcl-2 and Bcl-xL are capable of inhibiting anticancer drug-induced apoptosis, which is mediated by the voltage-dependent anion channel (VDAC) in the outer mitochondrial membrane, overexpression of Bcl-2 and Bcl-xL might confer resistance to chemotherapy [4].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Bcl-2 associated with apoptosis
13) Confidence 0.50 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.85 Pain Relevance 0
As shown in Fig. 4, MDA-MB-453 cells were resistant to DOX and MMC after transfection with the bcl-2 gene (P < 0.05, Student's t-test), whereas drug sensitivity to taxanes was not changed.
Positive_regulation (transfection) of Gene_expression (transfection) of bcl-2 in MDA-MB-453
14) Confidence 0.50 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.21 Pain Relevance 0
To determine the effect of Bcl-2 on chemosensitivity, cell proliferation was compared between MDA-MB-453/pZipneo and MDA-MB-453/Bcl-2-1 cells, which were transfected with empty plasmid vector or plasmid vector encoding the bcl-2 gene.
Positive_regulation (transfected) of Gene_expression (transfected) of bcl-2 in MDA-MB-453
15) Confidence 0.50 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.19 Pain Relevance 0
Intestinal tumors from Min/+ mice were harvested after treatment with sulindac for 2, 4 or 20 days and evaluated for expression of beta-catenin and Bcl-2 using immunohistochemistry.
Positive_regulation (evaluated) of Gene_expression (expression) of Bcl-2 associated with intestinal cancer
16) Confidence 0.49 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.95 Pain Relevance 0.22
Furthermore, we studied the effect of Bcl-2 gene transfection on the chemosensitivity of a breast cancer cell line that normally expresses a low basal level of Bcl-2.
Positive_regulation (transfection) of Gene_expression (transfection) of Bcl-2 associated with breast cancer
17) Confidence 0.46 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.65 Pain Relevance 0
Transfection of the Bcl-2 gene into MDA-MB-453 cells decreased sensitivity to DOX and MMC.
Positive_regulation (Transfection) of Gene_expression (Transfection) of Bcl-2 in MDA-MB-453
18) Confidence 0.46 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1410745 Disease Relevance 0.35 Pain Relevance 0
These results indicate that downregulation of Bcl-2 by AS Bcl-2 ODNs in breast cancer cells that normally overexpress Bcl-2 enhances their drug sensitivity, especially the sensitivity to DOX and taxanes.


Positive_regulation (overexpress) of Gene_expression (overexpress) of Bcl-2 associated with breast cancer
19) Confidence 0.46 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.10 Pain Relevance 0
Overexpression of Bcl-2 is observed more frequently than overexpression of Bcl-xL (70% versus 40%) in breast cancer tissue, which suggests a more important role for Bcl-2 in conferring drug resistance.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Bcl-2 associated with breast cancer
20) Confidence 0.46 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.47 Pain Relevance 0

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