INT81641

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Context Info
Confidence 0.72
First Reported 1998
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 14.93
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
colon 2
endothelial cells 2
plasma 1
hair follicle 1
small intestine 1
Ctnnb1 (Mus musculus)
Ctnnb1 - S33A (1)
Pain Link Frequency Relevance Heat
COX2 9 99.68 Very High Very High Very High
metalloproteinase 2 99.64 Very High Very High Very High
cINOD 34 99.40 Very High Very High Very High
Spinal cord 40 98.96 Very High Very High Very High
antagonist 4 98.00 Very High Very High Very High
Central nervous system 12 92.44 High High
Inflammation 65 89.92 High High
cytokine 21 74.08 Quite High
Neuritis 1 41.52 Quite Low
COX-2 inhibitor 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 367 100.00 Very High Very High Very High
Adhesions 52 100.00 Very High Very High Very High
Alagille Syndrome 110 99.86 Very High Very High Very High
Targeted Disruption 168 99.84 Very High Very High Very High
Intestinal Cancer 46 99.84 Very High Very High Very High
Chondrosarcoma 4 99.56 Very High Very High Very High
Colon Cancer 42 99.32 Very High Very High Very High
Adenoma 14 99.26 Very High Very High Very High
Chordoma 131 98.52 Very High Very High Very High
Apoptosis 101 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present investigation, it was examined with RT-PCR whether expression of beta-catenin, a downstream gene of Wnt in its signal transduction pathway, is regulated.
Spec (whether) Gene_expression (expression) of beta-catenin
1) Confidence 0.72 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367680 Disease Relevance 0.07 Pain Relevance 0.05
The aim of this study was to determine if NSAID-induced regression of intestinal adenomas might be associated with changes in beta-catenin or Bcl-2 expression.
Gene_expression (expression) of beta-catenin associated with adenoma and cinod
2) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.96 Pain Relevance 0.24
Cytoplasmic and nuclear beta-catenin are overexpressed in many of these lesions and Bcl-2, which inhibits apoptosis, may also be elevated during the course of intestinal tumorigenesis.
Gene_expression (overexpressed) of beta-catenin associated with apoptosis
3) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.73 Pain Relevance 0.25
Intestinal tumors from Min/+ mice were harvested after treatment with sulindac for 2, 4 or 20 days and evaluated for expression of beta-catenin and Bcl-2 using immunohistochemistry.
Gene_expression (expression) of beta-catenin associated with intestinal cancer
4) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.95 Pain Relevance 0.22
Colonic tumors expressed higher levels of Bcl-2 than those from the small intestine and did not show any significant changes in either Bcl-2 or beta-catenin expression after treatment.
Gene_expression (expression) of beta-catenin in small intestine associated with cancer
5) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.67 Pain Relevance 0.16
Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice.
Gene_expression (expression) of beta-catenin associated with intestinal cancer and cox2
6) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Title Doc Link 10223192 Disease Relevance 0.80 Pain Relevance 0.31
Results suggest that modulation of aberrant beta-catenin expression occurs during NSAID-induced regression of intestinal adenomas and that Bcl-2 may confer resistance to these effects.
Gene_expression (expression) of beta-catenin associated with adenoma and cinod
7) Confidence 0.70 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.74 Pain Relevance 0.17
-catenin expressed from retained intact CTNNB1, which contributes to the promotion of the total Wnt/?
Gene_expression (expressed) of CTNNB1
8) Confidence 0.68 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.60 Pain Relevance 0
On the other hand, AGS cells possess mutation in CTNNB1 close to the phosphorylation site of GSK3?
Gene_expression (possess) of CTNNB1 in AGS associated with alagille syndrome
9) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.54 Pain Relevance 0
-catenin gene (CTNNB1) at codon 34 (Caca et al, 1999; Supplementary Figure 2), whereas CTNNB1 is amplified in Kato-III cells (Suriano et al, 2005).
Gene_expression (amplified) of CTNNB1
10) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.98 Pain Relevance 0
-catenin accumulated cells after the transient transfection of mutant CTNNB1 (S33A) expression vector (Figure 3C).
Gene_expression (expression) of CTNNB1 (S33A)
11) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.32 Pain Relevance 0
-catenin gene (CTNNB1) at codon 34 (Caca et al, 1999; Supplementary Figure 2), whereas CTNNB1 is amplified in Kato-III cells (Suriano et al, 2005).
Gene_expression (amplified) of CTNNB1
12) Confidence 0.67 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.02 Pain Relevance 0
Mutations in exon 3 of CTNNB1 result in stabilization of a protein that resists degradation, leading to nuclear accumulation of ?
Gene_expression (exon) of CTNNB1
13) Confidence 0.43 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.99 Pain Relevance 0
It has been shown that microvascular endothelial cells, isolated from murine spinal cord, morphologically similar to BBB endothelial cells, express reduced amounts of several prominent BBB proteins such as tight junction-associated proteins ZO-1 and occluding, adherens junction-associated proteins beta-catenin and VE-cadherin, and the efflux transporter P-glycoprotein [50].
Gene_expression (express) of beta-catenin in endothelial cells associated with spinal cord
14) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.27 Pain Relevance 0.12
Myc causes depletion of BrdU from LRCs in the IFE, but unlike conditional expression of either TERT or beta-catenin, Myc has not been reported to initiate a new anagen cycle [53].
Gene_expression (expression) of beta-catenin
15) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.11 Pain Relevance 0
Expression of a more active beta-catenin variant in skin also promoted anagen, but in addition caused the formation of new hair follicles and ultimately hair follicle tumors [46,47].
Gene_expression (Expression) of beta-catenin in hair follicle associated with cancer
16) Confidence 0.17 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.
Gene_expression (deletion) of beta-catenin in colon associated with colon cancer
17) Confidence 0.14 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.16 Pain Relevance 0
This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.
Gene_expression (overexpression) of beta-catenin in colon associated with colon cancer
18) Confidence 0.14 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
The striking similarities between their gene expression programs and the fact that TERT expression phenocopies beta-catenin in skin suggest the possibility that TERT impinges upon the Wnt pathway (see Text S1 and Table S10 for additional details).
Gene_expression (expression) of beta-catenin in skin
19) Confidence 0.13 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.09 Pain Relevance 0
ligands omega-6 fatty acids and ciglitazone down-regulated

(1-2-fold) beta-catenin and c-myc expression and the selective PPAR?

Gene_expression (expression) of beta-catenin
20) Confidence 0.11 Published 2008 Journal PPAR Research Section Body Doc Link PMC2443425 Disease Relevance 0.43 Pain Relevance 0.15

General Comments

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