INT81642

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Context Info
Confidence 0.44
First Reported 1999
Last Reported 2010
Negated 8
Speculated 3
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 16.93
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
liver 2
lung 2
small intestine 2
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 9 99.98 Very High Very High Very High
dexamethasone 72 99.84 Very High Very High Very High
Morphine 120 99.60 Very High Very High Very High
cINOD 13 98.64 Very High Very High Very High
cytokine 68 98.08 Very High Very High Very High
withdrawal 12 97.72 Very High Very High Very High
antagonist 8 93.08 High High
agonist 3 91.52 High High
Kinase C 2 83.64 Quite High
palliative 2 77.36 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 198 100.00 Very High Very High Very High
Intestinal Cancer 12 99.84 Very High Very High Very High
Targeted Disruption 86 99.64 Very High Very High Very High
Adenoma 5 99.48 Very High Very High Very High
Apoptosis 585 99.12 Very High Very High Very High
Breast Cancer 88 99.08 Very High Very High Very High
Infection 227 98.92 Very High Very High Very High
Death 75 98.80 Very High Very High Very High
Pancreatic Cancer 41 98.48 Very High Very High Very High
Cancer 290 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colonic tumors expressed higher levels of Bcl-2 than those from the small intestine and did not show any significant changes in either Bcl-2 or beta-catenin expression after treatment.
Neg (not) Regulation (changes) of Gene_expression (expression) of Bcl-2 in small intestine associated with cancer
1) Confidence 0.44 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.68 Pain Relevance 0.16
B regulation of Bcl-2 expression alone does not account for the phenotype of the I?
Regulation (regulation) of Gene_expression (expression) of Bcl-2
2) Confidence 0.41 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.20 Pain Relevance 0
A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo.
Regulation (modulates) of Gene_expression (expression) of BCL-2 in liver associated with paracetamol, apoptosis and death
3) Confidence 0.39 Published 2000 Journal Arch. Toxicol. Section Title Doc Link 10663392 Disease Relevance 0.85 Pain Relevance 0.45
Extending the analysis of latency in Bcl-2 transgenic mice, we observed at later times postinfection that there was a slightly greater defect in latency in Bcl-2 trangenic mice infected with I?
Regulation (latency) of Gene_expression (trangenic) of Bcl-2 associated with targeted disruption
4) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1781481 Disease Relevance 0.18 Pain Relevance 0
PADMA 28 interferes with Bcl-2 function
Regulation (interferes) of Gene_expression (function) of Bcl-2
5) Confidence 0.35 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.32 Pain Relevance 0.03
No differences in Bcl-2 expression between knockout and wild-type mice was seen at 4 h after TBI (Fig. 5).
Neg (No) Regulation (differences) of Gene_expression (expression) of Bcl-2 associated with targeted disruption and brain injury
6) Confidence 0.28 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1540436 Disease Relevance 0.93 Pain Relevance 0.14
Activated Akt induces the alteration of Bcl2 and Bax expression and plays an antiapoptotic role in several different cell types [26].
Regulation (alteration) of Gene_expression (expression) of Bcl2
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 0.74 Pain Relevance 0.65
After determining that the expression of Bcl-2 in the AKR/J spontaneous lymphomas was not altered while Fas expression was markedly decreased in all thymomas tested, the mechanisms underlying apoptosis induced by bacterial Sags in two lymphomas were studied.
Neg (not) Regulation (altered) of Gene_expression (expression) of Bcl-2 associated with lymphatic system cancer, thymoma and apoptosis
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.23 Pain Relevance 0
Exposure to specific bacterial Sags did not induced alterations in Bcl-2 expression or in the level of expression of TNFR1 and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) (data not shown).
Neg (not) Regulation (alterations) of Gene_expression (expression) of Bcl-2 associated with necrosis, cancer and apoptosis
9) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.60 Pain Relevance 0
Furthermore, we studied the effect of Bcl-2 gene transfection on the chemosensitivity of a breast cancer cell line that normally expresses a low basal level of Bcl-2.
Regulation (effect) of Gene_expression (transfection) of Bcl-2 associated with breast cancer
10) Confidence 0.27 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.66 Pain Relevance 0
These findings suggest differential regulation in the expression of Bcl-2 and Bcl-xL protein in breast cancer cells.


Regulation (regulation) of Gene_expression (expression) of Bcl-2 associated with breast cancer
11) Confidence 0.27 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.38 Pain Relevance 0
We examined the effect of AS oligonucleotide treatment on Bcl-2 protein expression.
Spec (examined) Regulation (effect) of Gene_expression (expression) of Bcl-2
12) Confidence 0.27 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410745 Disease Relevance 0.26 Pain Relevance 0
The aim of this study was to determine if NSAID-induced regression of intestinal adenomas might be associated with changes in beta-catenin or Bcl-2 expression.
Regulation (changes) of Gene_expression (expression) of Bcl-2 associated with adenoma and cinod
13) Confidence 0.26 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.96 Pain Relevance 0.24
Bcl-2 expression is controlled, to some extent, by liberation of the Th1-type cytokine IFN-?
Regulation (controlled) of Gene_expression (expression) of Bcl-2 associated with cytokine
14) Confidence 0.21 Published 2005 Journal J Carcinog Section Body Doc Link PMC1232859 Disease Relevance 0.37 Pain Relevance 0.10
However, TM treatment did not alter the Bcl-2 expression (data not shown).
Neg (not) Regulation (alter) of Gene_expression (expression) of Bcl-2
15) Confidence 0.17 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.08 Pain Relevance 0.08
However, morphine with H37Ra did not alter the levels of Bcl-2 (Fig. 4A) and Bax (Fig. 4B) in the lung from TLR9 KO mice.
Neg (not) Regulation (alter) of Gene_expression (levels) of Bcl-2 in lung associated with targeted disruption and morphine
16) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824811 Disease Relevance 1.08 Pain Relevance 0.80
Synthetic hBCL2-BH4 and hBCL2A1-BH4 peptides were both effective in reducing I/R, whereas a peptide from the BH3 domain of Bak, a pro-apoptotic BCL2 family member, was not (Figure 3).


Regulation (effective) of Gene_expression (peptides) of hBCL2-BH4 associated with apoptosis
17) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.62 Pain Relevance 0
Therefore, enhanced expression of MKP-1, SGK-1, X-IAP and Bcl-2 but not of BAG-1 may be involved in DEX-induced therapy resistance of pancreatic carcinomas.


Spec (may) Regulation (involved) of Gene_expression (expression) of Bcl-2 associated with pancreatic cancer and dexamethasone
18) Confidence 0.10 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.86 Pain Relevance 0.24
Bcl-2 restoration did not affect the viability of MDA-MB-435-E1A stable transfectants after a 5-day treatment with 40 ?
Neg (not) Regulation (affect) of Gene_expression (restoration) of Bcl-2
19) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.64 Pain Relevance 0
Bcl-2 suppression does not contribute to celecoxib-induced apoptosis in E1A stable transfectants
Neg (not) Regulation (contribute) of Gene_expression (suppression) of Bcl-2 associated with apoptosis
20) Confidence 0.08 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206712 Disease Relevance 0.40 Pain Relevance 0.06

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