INT81643

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Context Info
Confidence 0.57
First Reported 1998
Last Reported 1999
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
small intestine 2
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 99.40 Very High Very High Very High
Central nervous system 1 92.44 High High
Neuritis 1 47.52 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 4 97.94 Very High Very High Very High
Adenoma 4 97.84 Very High Very High Very High
Intestinal Cancer 12 91.64 High High
Rheumatoid Arthritis 1 75.00 Quite High
Apoptosis 4 55.00 Quite High
INFLAMMATION 2 43.28 Quite Low
Neuritis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present investigation, it was examined with RT-PCR whether expression of beta-catenin, a downstream gene of Wnt in its signal transduction pathway, is regulated.
Spec (whether) Regulation (regulated) of Spec (whether) Gene_expression (expression) of beta-catenin
1) Confidence 0.57 Published 1998 Journal Sheng Li Xue Bao Section Abstract Doc Link 11367680 Disease Relevance 0.07 Pain Relevance 0.05
Results suggest that modulation of aberrant beta-catenin expression occurs during NSAID-induced regression of intestinal adenomas and that Bcl-2 may confer resistance to these effects.
Regulation (modulation) of Gene_expression (expression) of beta-catenin associated with adenoma and cinod
2) Confidence 0.56 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.75 Pain Relevance 0.17
Colonic tumors expressed higher levels of Bcl-2 than those from the small intestine and did not show any significant changes in either Bcl-2 or beta-catenin expression after treatment.
Neg (not) Regulation (changes) of Gene_expression (expression) of beta-catenin in small intestine associated with cancer
3) Confidence 0.56 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.68 Pain Relevance 0.16

General Comments

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