INT81644

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.38
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
colon 2
small intestine 1
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 91.12 High High
COX-2 inhibitor 1 80.64 Quite High
agonist 9 61.56 Quite High
COX2 2 25.00 Low Low
Inflammation 66 5.00 Very Low Very Low Very Low
cytokine 23 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 100.00 Very High Very High Very High
Aberrant Crypt Foci 3 99.64 Very High Very High Very High
Microsatellite Instability 47 99.56 Very High Very High Very High
Colon Cancer 18 98.84 Very High Very High Very High
Cancer 114 97.94 Very High Very High Very High
Aneuploidy 3 96.32 Very High Very High Very High
Chromosomal Instability 1 92.08 High High
Intestinal Cancer 8 91.64 High High
Adenoma 5 86.96 High High
Carcinoma 61 81.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colonic tumors expressed higher levels of Bcl-2 than those from the small intestine and did not show any significant changes in either Bcl-2 or beta-catenin expression after treatment.
Neg (not) Regulation (changes) of beta-catenin in small intestine associated with cancer
1) Confidence 0.41 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.68 Pain Relevance 0.16
Importantly, mPGES-1 deletion also blocked the nuclear accumulation of beta-catenin in ACF, confirming that beta-catenin is a critical target of PGE(2) procarcinogenic signaling in the colon.
Regulation (target) of beta-catenin in colon associated with aberrant crypt foci
2) Confidence 0.14 Published 2008 Journal Cancer Res. Section Abstract Doc Link 18451151 Disease Relevance 0.84 Pain Relevance 0.13
-catenin degradation and downregulates its transcriptional activity in colon cancer cells, thus revealing a so-far-unidentified mechanism of beta-catenin regulation [114].
Regulation (regulation) of beta-catenin in colon associated with colon cancer
3) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.22 Pain Relevance 0.09
Furthermore, none of the five main alterations of endometrioid endometrial carcinoma (mutations of PTEN, PIK3CA, KRAS, and CTNNB1 genes and MSI) plays a major role in non-endometrioid endometrial carcinoma.
Regulation (alterations) of CTNNB1 associated with microsatellite instability and endometrial cancer
4) Confidence 0.09 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.57 Pain Relevance 0
However, Myc is already linked to the Wnt pathway by virtue of being an important transcriptional target of beta-catenin [54].
Regulation (target) of beta-catenin
5) Confidence 0.06 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.07 Pain Relevance 0

General Comments

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