INT81645

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Context Info
Confidence 0.63
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.78
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ctnnb1) enzyme binding (Ctnnb1) DNA binding (Ctnnb1)
protein complex (Ctnnb1) cytoplasm (Ctnnb1) cell proliferation (Ctnnb1)
Anatomy Link Frequency
colon 2
AGS 2
Ctnnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 92.48 High High
metalloproteinase 1 31.04 Quite Low
cytokine 4 27.80 Quite Low
COX2 2 25.00 Low Low
Inflammation 11 24.64 Low Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alagille Syndrome 22 99.86 Very High Very High Very High
Targeted Disruption 36 99.84 Very High Very High Very High
Colon Cancer 12 99.32 Very High Very High Very High
Intestinal Cancer 14 98.28 Very High Very High Very High
Apoptosis 39 97.92 Very High Very High Very High
Cystic Kidney Diseases 8 96.92 Very High Very High Very High
Adenoma 5 93.04 High High
INFLAMMATION 16 91.92 High High
Familial Adenomatous Polyposis 1 91.28 High High
Cancer 127 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytoplasmic and nuclear beta-catenin are overexpressed in many of these lesions and Bcl-2, which inhibits apoptosis, may also be elevated during the course of intestinal tumorigenesis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of beta-catenin associated with apoptosis
1) Confidence 0.63 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.73 Pain Relevance 0.25
On the other hand, AGS cells possess mutation in CTNNB1 close to the phosphorylation site of GSK3?
Positive_regulation (mutation) of Gene_expression (possess) of CTNNB1 in AGS associated with alagille syndrome
2) Confidence 0.50 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.54 Pain Relevance 0
Intestinal tumors from Min/+ mice were harvested after treatment with sulindac for 2, 4 or 20 days and evaluated for expression of beta-catenin and Bcl-2 using immunohistochemistry.
Positive_regulation (evaluated) of Gene_expression (expression) of beta-catenin associated with intestinal cancer
3) Confidence 0.46 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10223192 Disease Relevance 0.95 Pain Relevance 0.22
Mutations in exon 3 of CTNNB1 result in stabilization of a protein that resists degradation, leading to nuclear accumulation of ?
Positive_regulation (Mutations) of Gene_expression (exon) of CTNNB1
4) Confidence 0.32 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 0.99 Pain Relevance 0
This advantage is well illustrated here because our TERT gene set derived from mouse skin matched Wnt pathway patterns seen with conditional deletion of the beta-catenin regulator Apc in mouse gastrointestinal tract and with overexpression of Apc in human colon cancer cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of beta-catenin in colon associated with colon cancer
5) Confidence 0.11 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
Overexpression of beta-catenin in transgenic animals or inactivation of APC resulted in the development of cystic kidneys [91, 92].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of beta-catenin associated with targeted disruption and cystic kidney diseases
6) Confidence 0.04 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.40 Pain Relevance 0

General Comments

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