INT81664

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Context Info
Confidence 0.68
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 12
Total Number 12
Disease Relevance 2.51
Pain Relevance 9.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pnoc)
Anatomy Link Frequency
astrocytes 8
brain 4
heart 4
plasma 2
spinal cord 2
Pnoc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
orphanin 66 100.00 Very High Very High Very High
Morphine 40 100.00 Very High Very High Very High
narcan 12 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Enkephalin 7 100.00 Very High Very High Very High
anesthesia 2 100.00 Very High Very High Very High
Inflammation 7 99.98 Very High Very High Very High
IPN 1 99.78 Very High Very High Very High
vanilloid receptor subtype 1 4 99.04 Very High Very High Very High
Dorsal horn 1 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 6 100.00 Very High Very High Very High
INFLAMMATION 4 99.98 Very High Very High Very High
Hepatocellular Cancer 2 99.84 Very High Very High Very High
Inflammatory Pain 1 99.78 Very High Very High Very High
Nociception 2 94.16 High High
Pain 3 93.44 High High
Cognitive Disorder 1 92.72 High High
Leukemia 2 92.16 High High
Hepatolenticular Degeneration 1 89.16 High High
Urological Neuroanatomy 3 83.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that peripheral inflammation induces the production of nociceptin in a sub-population of VR1-positive primary sensory neurons and support the idea that nociceptin produced there is involved in the regulation of nociceptive processing.
Positive_regulation (induces) of Gene_expression (production) of nociceptin in primary sensory neurons associated with nociception, vanilloid receptor subtype 1, inflammation and orphanin
1) Confidence 0.68 Published 2001 Journal Neurosci. Res. Section Abstract Doc Link 11448514 Disease Relevance 0.49 Pain Relevance 0.75
Chronic inflammatory pain causes an increase in the expression of nociceptin and the ORL1 receptor in the dorsal horn of rat spinal cord, thus indicating an involvement of the endogenous nociceptin/ORL1 system in mechanisms of pathological pain.
Positive_regulation (increase) of Gene_expression (expression) of nociceptin in spinal cord associated with pain, orphanin, ipn, dorsal horn and spinal cord
2) Confidence 0.65 Published 2004 Journal Anaesthesist Section Abstract Doc Link 15127152 Disease Relevance 0.54 Pain Relevance 1.09
Microinjection of nociceptin (Orphanin FQ) into nucleus tractus solitarii elevates blood pressure and heart rate in both anesthetized and conscious rats.
Positive_regulation (elevates) of Gene_expression (Microinjection) of nociceptin in heart associated with anesthesia and orphanin
3) Confidence 0.50 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 10871320 Disease Relevance 0.36 Pain Relevance 0.66
Ir levels of dynorphin A, dynorphin B, Leu-enkephalin-Arg(6), Met-enkephalin-Arg(6)Phe(7) and nociceptin/orphanin FQ were measured in the pituitary gland and in 10 areas of the brain during the diestrus, proestrus and estrus phase.
Positive_regulation (measured) of Gene_expression (levels) of nociceptin in brain associated with dynorphin, orphanin and enkephalin
4) Confidence 0.49 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16540166 Disease Relevance 0 Pain Relevance 0.92
Microinjections of nociceptin, an endogenous ligand for the nociceptin receptor, into the relatively rostral NTS produced dose-related (0.04, 0.2, and 1 nmol) increases in blood pressure and heart rate.
Positive_regulation (increases) of Gene_expression (produced) of nociceptin in heart associated with pressure and volume under development and orphanin
5) Confidence 0.41 Published 2005 Journal Neuroscience Section Abstract Doc Link 15857705 Disease Relevance 0.25 Pain Relevance 0.81
Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats.
Positive_regulation (Accelerated) of Gene_expression (production) of orphanin FQ in brain associated with orphanin and morphine
6) Confidence 0.40 Published 1999 Journal Brain Res. Section Title Doc Link 10224316 Disease Relevance 0.24 Pain Relevance 1.23
Nociceptin mRNA expression was increased by treatment with 20 or 80 ng/ml LIF for 24 h, but choline acetyl transferase, glutamic acid decarboxylase, enkephalin, dynorphin, substance P, somatostatin and galanin mRNA expression were not altered by LIF.
Positive_regulation (increased) of Gene_expression (expression) of Nociceptin mRNA associated with dynorphin, orphanin, somatostatin, enkephalin and substance p
7) Confidence 0.23 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11585557 Disease Relevance 0.17 Pain Relevance 0.46
Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine
8) Confidence 0.05 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82
Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine
9) Confidence 0.04 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82
Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine
10) Confidence 0.04 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82
Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.
Positive_regulation (Morphine-induced) of Gene_expression (overexpression) of prepro-nociceptin/orphanin in astrocytes associated with orphanin and morphine
11) Confidence 0.04 Published 2005 Journal Peptides Section Title Doc Link 15990199 Disease Relevance 0 Pain Relevance 0.82
Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma.
Positive_regulation (Increased) of Gene_expression (levels) of nociceptin in plasma associated with orphanin and hepatocellular cancer
12) Confidence 0.03 Published 2004 Journal World J. Gastroenterol. Section Title Doc Link 14695766 Disease Relevance 0.46 Pain Relevance 0.52

General Comments

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