INT81688

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Context Info
Confidence 0.41
First Reported 1999
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 32
Total Number 33
Disease Relevance 30.13
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Renal artery 2
blood 1
coronary artery 1
blood vessels 1
cornea 1
ras (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 56 100.00 Very High Very High Very High
Chronic pancreatitis 36 100.00 Very High Very High Very High
Eae 8 99.96 Very High Very High Very High
backache 5 99.10 Very High Very High Very High
corticosteroid 7 94.88 High High
depression 6 94.28 High High
dexamethasone 53 93.92 High High
beta blocker 6 87.56 High High
peptic ulcer disease 1 87.56 High High
cytokine 48 87.48 High High
Disease Link Frequency Relevance Heat
Canker Sores 239 100.00 Very High Very High Very High
Nicotine Addiction 238 100.00 Very High Very High Very High
Pancreatitis 39 100.00 Very High Very High Very High
Renal Artery Obstruction 26 100.00 Very High Very High Very High
Post-traumatic Stress Disorder 10 100.00 Very High Very High Very High
Hypertension 160 99.90 Very High Very High Very High
Coronary Artery Disease 133 99.80 Very High Very High Very High
Malignant Neoplastic Disease 7 99.80 Very High Very High Very High
Left Ventricular Hypertrophy 28 99.76 Very High Very High Very High
Vomiting 255 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the results of this study did not entirely exclude a possible negative epidemiological association between smoking and RAS.
RAS Neg (negative) Binding (association) of associated with nicotine addiction and canker sores
1) Confidence 0.41 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.23 Pain Relevance 0.05
Furthermore, the recent release of direct renin inhibitors potentially may add even more information to the association of RAS and coronary atherosclerosis.
RAS Binding (association) of associated with coronary artery disease
2) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.12 Pain Relevance 0.03
Given the potential of the differing medical therapies in these three studies, there has been some interest in further evaluating the interaction of RAS blockade and lipid lowering therapy.
RAS Binding (interaction) of
3) Confidence 0.40 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.37 Pain Relevance 0.04
In addition, increase in incidence of RAS in those who ceased smoking9–13 is not a proof that smoking is responsible since other factors could be involved such as increased stress and depression, which usually affect these subjects when they stop smoking.16
RAS Binding (incidence) of associated with stress, nicotine addiction, depression and canker sores
4) Confidence 0.36 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 2.05 Pain Relevance 0.05
Renal artery stenosis (RAS) has traditionally been under recognized in clinical medicine as a cause of secondary hypertension and as a culprit for progressive ischemic nephropathy.
RAS Binding (recognized) of in Renal artery associated with renal artery obstruction, renal disease and hypertension
5) Confidence 0.35 Published 2005 Journal Minerva Cardioangiol Section Abstract Doc Link 15788982 Disease Relevance 0.86 Pain Relevance 0
Suspected bacteria and viruses may also associate with RAS [6].
RAS Binding (associate) of associated with canker sores
6) Confidence 0.33 Published 2009 Journal Trials Section Body Doc Link PMC2690593 Disease Relevance 1.56 Pain Relevance 0.15
This report summarizes the findings of CFFHHS, which indicate that back pain is common among farmers and most frequently attributed to repeated activities (RAs) (e.g. lifting, pushing, pulling, bending, twisting, and reaching).
RAs Binding (attributed) of associated with backache
7) Confidence 0.31 Published 1999 Journal MMWR Morb. Mortal. Wkly. Rep. Section Abstract Doc Link 10227797 Disease Relevance 0.49 Pain Relevance 0.41
This interaction between the RAS and glucose metabolism has been further supported by analyzing the effects of RAS blockade on enhanced insulin sensitivity.
RAS Binding (interaction) of
8) Confidence 0.31 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 1.00 Pain Relevance 0.03
Our findings contradict previous studies that found a negative epidemiological association between tobacco use and RAS.4–13 Some of these studies were observational studies on three or four patients12,13 or recruited a small number of patients with RAS.6,8 Other studies were conducted in hospitals or university clinics with a possible selection bias.6,7 In addition, other studies that found significant relationships between smoking and RAS used only bivariate analyses.5–7 Several variables found to be significant in bivariate analyses may turn insignificant in multivariate model.
RAS Neg (negative) Spec (found) Binding (association) of associated with nicotine addiction and canker sores
9) Confidence 0.31 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2999509 Disease Relevance 1.29 Pain Relevance 0
The potential for renin inhibition as a target for blockade of the RAS has been considered for more than 30 years, as renin is the initial and rate limiting step in the RAS system (Skegg et al 1957).
RAS Binding (target) of
10) Confidence 0.30 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350139 Disease Relevance 0.35 Pain Relevance 0.08
Very similar results were obtained by Kamiya and colleagues14 who compared angiographic and pathologic findings of RAs used as conduits for coronary artery bypass between patients who underwent transradial catheterization and those who did not.
RAs Binding (findings) of in coronary artery
11) Confidence 0.30 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2704894 Disease Relevance 0.59 Pain Relevance 0
In contrast, ras mutations are associated with smoking, one acknowledged risk factor for pancreatic carcinoma.
ras Binding (associated) of associated with nicotine addiction and pancreatic cancer
12) Confidence 0.29 Published 2000 Journal Int. J. Pancreatol. Section Abstract Doc Link 10862508 Disease Relevance 0.76 Pain Relevance 0.16
Given the histological similarities between gastric and oral ulceration, it seemed prudent to investigate a possible association between H. pylori and recurrent aphthous stomatitis (RAS).
RAS Binding (association) of associated with mouth ulcer and canker sores
13) Confidence 0.21 Published 2000 Journal J. Oral Pathol. Med. Section Abstract Doc Link 11048967 Disease Relevance 1.23 Pain Relevance 0.09
Ang II has been known as the effector peptide of RAS that directly binds to blood vessels and induces vasoconstriction.
RAS Binding (binds) of in blood vessels associated with increased venous pressure under development
14) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673691 Disease Relevance 2.31 Pain Relevance 0.12
The effects of dnCaMKIV on mean locomotor activity, ASR, social interaction and emergence test behaviour were evaluated by Student's t-tests.
ASR Binding (interaction) of associated with post-traumatic stress disorder and eae
15) Confidence 0.08 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.44 Pain Relevance 0.08
Part of the reason for this is that vascular surgeons remain cautious about commencing ACE inhibitors in a patient population that has a high perceived risk of RAS.
RAS Binding (risk) of associated with renal artery obstruction
16) Confidence 0.07 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2496985 Disease Relevance 1.30 Pain Relevance 0.07
Moreover, the discoveries that Ang II can be generated by enzymes other than angiotensin-converting enzyme (ACE) and that Ang II and other RAS derived peptides bind to various receptors with different functional consequences have further added to the complexity of this system.
RAS Binding (bind) of
17) Confidence 0.06 Published 2005 Journal Kidney Int. Section Abstract Doc Link 15698420 Disease Relevance 0.36 Pain Relevance 0.03
Palonosetron has proven to be an excellent addition to the armamentarium against CINV, specifically against delayed and overall CINV, which until now has proved difficult to treat with conventional 5-HT3 RAs.
RAs Binding (treat) of associated with vomiting
18) Confidence 0.05 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387285 Disease Relevance 0.83 Pain Relevance 0.09
According to the most recent indication for CINV prevention, 5HT3 RAs are unanimously recognised to be the foundation of antiemetic therapy. 5HT3 RAs should then be given in combination with other antiemetic agents, usually corticosteroids such as dexamethasone and NK1 RAs, in accordance to the evaluation of patient-related and treatment-related risk factors, in particular the chemotherapy emetogenicity (HEC or MEC).
RAs Binding (recognised) of associated with corticosteroid, vomiting and dexamethasone
19) Confidence 0.05 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2387285 Disease Relevance 1.04 Pain Relevance 0.09
The renin-angiotensin system (RAS) is recognized as an important contributor to hypertension [22], and the majority of research concerned with this system has focused on the synthesis of AngII and its interaction with angiotensin receptors [23].
RAS Binding (recognized) of associated with hypertension
20) Confidence 0.05 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005972 Disease Relevance 0.57 Pain Relevance 0.03

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