INT81695

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1999
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 7.29
Pain Relevance 3.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (OSM) extracellular space (OSM) extracellular region (OSM)
Anatomy Link Frequency
MDMs 2
monocyte 1
cartilage 1
articular cartilage 1
mononuclear cells 1
OSM (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 294 100.00 Very High Very High Very High
Inflammation 154 100.00 Very High Very High Very High
metalloproteinase 30 99.68 Very High Very High Very High
Osteoarthritis 242 97.68 Very High Very High Very High
chemokine 24 95.52 Very High Very High Very High
anesthesia 5 90.64 High High
Angina 2 85.24 High High
COX2 2 64.88 Quite High
agonist 5 39.72 Quite Low
Inflammatory mediators 22 38.88 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 183 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 99.34 Very High Very High Very High
Chondrosarcoma 6 98.66 Very High Very High Very High
Osteoarthritis 171 97.68 Very High Very High Very High
Apoptosis 32 97.52 Very High Very High Very High
Congenital Anomalies 7 95.88 Very High Very High Very High
Bacterial Infection 7 95.04 Very High Very High Very High
Increased Venous Pressure Under Development 16 93.68 High High
Disease 40 91.28 High High
Infection 30 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation.
Gene_expression (expression) of oncostatin M in macrophages associated with inflammation
1) Confidence 0.75 Published 2009 Journal Blood Section Title Doc Link 19652200 Disease Relevance 1.13 Pain Relevance 0.41
The ERK1/2 inhibitor PD98059 blocked the effect of thrombin on OSM production in MDMs, whereas the p38 inhibitor SB202190 had no effect.
Gene_expression (production) of OSM in MDMs
2) Confidence 0.75 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 0.93 Pain Relevance 0.29
Not surprisingly, as EGR-1 is known to activate cytokines, such signaling molecules are present in the arsenic biomarker gene set; namely, OSM (oncostatin M), a member of the interleukin-6 (IL-6) family of cytokines known to control cell cycle progression [16], CXL1 (chemokine ligand 1), and SOC (suppressor of cytokine signaling 3).
Gene_expression (present) of OSM associated with chemokine and cytokine
3) Confidence 0.55 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0.23 Pain Relevance 0.31
Not surprisingly, as EGR-1 is known to activate cytokines, such signaling molecules are present in the arsenic biomarker gene set; namely, OSM (oncostatin M), a member of the interleukin-6 (IL-6) family of cytokines known to control cell cycle progression [16], CXL1 (chemokine ligand 1), and SOC (suppressor of cytokine signaling 3).
Gene_expression (present) of oncostatin M associated with chemokine and cytokine
4) Confidence 0.55 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC2082467 Disease Relevance 0.23 Pain Relevance 0.32
Inflammatory cytokines and HIV-1-associated neurodegeneration: oncostatin-M produced by mononuclear cells from HIV-1-infected individuals induces apoptosis of primary neurons.
Gene_expression (produced) of oncostatin-M in mononuclear cells associated with inflammation, acquired immune deficiency syndrome or hiv infection, apoptosis and cytokine
5) Confidence 0.53 Published 1999 Journal J. Immunol. Section Title Doc Link 10229874 Disease Relevance 1.04 Pain Relevance 0.32
The data for all cultures identified as normal cells (Fig. 7A) indicated that low concentrations of OSM (?
Gene_expression (concentrations) of OSM
6) Confidence 0.48 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.30 Pain Relevance 0
In all cell types, OSM reduced in a dose-dependent manner proliferation, with maximal effect at a concentration of 20 to 100 ng/ml.
Gene_expression (reduced) of OSM
7) Confidence 0.48 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.20 Pain Relevance 0.12
The expression of the BMP4 and LIF/OSM receptor in urinary tract SMCs may be a vestige of their developmental origins and suggests the possibility that these cells may retain some of the developmental plasticity of their progenitors.
Gene_expression (expression) of OSM
8) Confidence 0.44 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0 Pain Relevance 0
Also pro-inflammatory cytokines oncostatin-M (OSM) [27] and interferon-gamma (IFN-?)
Gene_expression (pro) of OSM associated with inflammation and cytokine
9) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.79 Pain Relevance 0.53
It is not clear to what extent the increased levels of IL-6, OSM and lower levels of OPG in conditioned serum may have had a pro-inflammatory effect, but as conditioned serum addition did not result in decreased sulphate incorporation after four days of cartilage explant culture, or a lower PG content after 16 days of culture, conditioning of serum is not likely to have any effect on OA cartilage.
Gene_expression (levels) of OSM in cartilage associated with inflammation and osteoarthritis
10) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.46 Pain Relevance 0.33
Also pro-inflammatory cytokines oncostatin-M (OSM) [27] and interferon-gamma (IFN-?)
Gene_expression (pro) of cytokines oncostatin-M associated with inflammation and cytokine
11) Confidence 0.34 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.79 Pain Relevance 0.53
, TRAIL, CXCL10, and OSM) that we found prominently expressed in HMB-PP-stimulated monocyte-??
Gene_expression (expressed) of OSM in monocyte
12) Confidence 0.19 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.62 Pain Relevance 0.03
For pull-down experiments, vectors encoding FLAG-tagged Krit1 and OSM were transfected into HEK293 cells (the American Type Culture Collection (ATCC) Rockville, MA, USA) using lipofectamine.
Gene_expression (transfected) of OSM
13) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
Hence, we conducted proof of concept laboratory studies using DADS in a chondrosarcoma cell line, measuring both cellular acetylation and its ability to repress the IL-1/OSM-induced expression of key matrix-degrading metalloproteinases as a surrogate for the destruction/protection of articular cartilage.
Gene_expression (repress) of OSM in articular cartilage associated with chondrosarcoma and metalloproteinase
14) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3018463 Disease Relevance 0.36 Pain Relevance 0.11
DADS is reported to have HDAC inhibitor activity [28] so we measured both the activity of DADS to induce acetylation of histones, and also its ability to repress the IL-1 or IL-1/OSM-induced expression of key MMPs, MMP-1 and -13 (collagen-degrading enzymes) and MMP-3 (an activator of proMMPs) in a model cell line.
Gene_expression (expression) of OSM associated with metalloproteinase
15) Confidence 0.08 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3018463 Disease Relevance 0.20 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox