INT817

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Context Info
Confidence 0.49
First Reported 1978
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 4.25
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Abp1) oxidoreductase activity (Abp1) extracellular region (Abp1)
plasma membrane (Abp1) biological_process (Abp1)
Anatomy Link Frequency
brain 1
Abp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
monoamine 1 100.00 Very High Very High Very High
alcohol 7 99.72 Very High Very High Very High
Potency 7 99.68 Very High Very High Very High
colic 1 99.52 Very High Very High Very High
Clonidine 6 99.04 Very High Very High Very High
agonist 5 98.80 Very High Very High Very High
headache 41 97.28 Very High Very High Very High
Spinal cord 2 94.40 High High
Bioavailability 1 92.56 High High
carbamazepine 1 91.72 High High
Disease Link Frequency Relevance Heat
Urticaria 4 99.90 Very High Very High Very High
Disease 6 98.84 Very High Very High Very High
Erectile Dysfunction 7 97.92 Very High Very High Very High
Increased Venous Pressure Under Development 13 97.68 Very High Very High Very High
Headache 23 97.28 Very High Very High Very High
Headache Disorders 9 97.24 Very High Very High Very High
Adverse Drug Reaction 7 96.72 Very High Very High Very High
Toxicity 1 93.08 High High
Hypertension 2 92.64 High High
Poisoning 2 91.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recurrent urticaria and reduced diamine oxidase activity.
Negative_regulation (reduced) of diamine oxidase associated with urticaria and colic
1) Confidence 0.49 Published 1990 Journal Clin. Exp. Allergy Section Title Doc Link 2115815 Disease Relevance 0.45 Pain Relevance 0.13
However, infusion of 300 mg of cimetidine inhibited diamine oxidase activity by 27 +/- 7% 15 min after infusion, demonstrating that drugs may inhibit diamine oxidase in vivo.
Spec (may) Negative_regulation (inhibit) of diamine oxidase
2) Confidence 0.43 Published 2001 Journal Urol. Int. Section Body Doc Link 11464118 Disease Relevance 0 Pain Relevance 0
Sildanefil's potency as inhibitor of diamine oxidase was investigated, as side effects may also be induced by histamine itself due to an impaired histamine metabolism.
Negative_regulation (inhibitor) of diamine oxidase associated with potency
3) Confidence 0.43 Published 2001 Journal Urol. Int. Section Abstract Doc Link 11464118 Disease Relevance 0.39 Pain Relevance 0.15
However, infusion of 300 mg of cimetidine inhibited diamine oxidase activity by 27 +/- 7% 15 min after infusion, demonstrating that drugs may inhibit diamine oxidase in vivo.
Negative_regulation (inhibited) of diamine oxidase
4) Confidence 0.43 Published 2001 Journal Urol. Int. Section Body Doc Link 11464118 Disease Relevance 0 Pain Relevance 0
Are adverse effects of sildenafil also caused by inhibition of diamine oxidase?
Negative_regulation (inhibition) of diamine oxidase
5) Confidence 0.43 Published 2001 Journal Urol. Int. Section Title Doc Link 11464118 Disease Relevance 0.39 Pain Relevance 0.14
CONCLUSION: As side effects of sildenafil are not caused due to inhibition of diamine oxidase, sildenafil citrate seems to be harmless for patients suffering from histamine intolerance.


Negative_regulation (inhibition) of diamine oxidase
6) Confidence 0.43 Published 2001 Journal Urol. Int. Section Body Doc Link 11464118 Disease Relevance 0 Pain Relevance 0
In 9 male volunteers in vivo diamine oxidase inhibition was investigated after taking 100 mg sildenafil (Viagra).
Negative_regulation (inhibition) of diamine oxidase
7) Confidence 0.43 Published 2001 Journal Urol. Int. Section Body Doc Link 11464118 Disease Relevance 0 Pain Relevance 0
However, ith of 5-HT3 receptor agonist 2-Methylserotonin (25, 50, 100 micrograms/10 microliters), decreased mABP markedly without change in HR.
Negative_regulation (decreased) of mABP associated with agonist
8) Confidence 0.37 Published 1991 Journal Sheng Li Xue Bao Section Abstract Doc Link 1796318 Disease Relevance 0.26 Pain Relevance 0.33
RESULTS: Sildenafil citrate did not inhibit placental diamine oxidase either in vitro or in vivo.
Negative_regulation (inhibit) of diamine oxidase
9) Confidence 0.31 Published 2001 Journal Urol. Int. Section Body Doc Link 11464118 Disease Relevance 0 Pain Relevance 0
The episode was speculated to be due to two conditions; eating spoiled raw tuna and at the same time being on a course of INH, a potent histaminase inhibitor.
Negative_regulation (inhibitor) of histaminase
10) Confidence 0.22 Published 1997 Journal Intern. Med. Section Abstract Doc Link 9144013 Disease Relevance 0.43 Pain Relevance 0.09
The anxiolytic-like effect of ethanol was potentiated by pretreatment with imidazoline I(1)/I(2) receptor agonist agmatine (10-20 mg/kg, i.p.), imidazoline I(1) receptor agonists, moxonidine (0.25 mg/kg, i.p.) and clonidine (0.015 mg/kg, i.p.), imidazoline I(2) receptor agonist, 2-BFI (5 mg/kg, i.p.) as well as by the drugs known to increase endogenous agmatine levels in brain viz., L-arginine, an agmatine biosynthetic precursor (100 microg/rat, i.c.v.), ornithine decarboxylase inhibitor, DFMO (125 microg/rat, i.c.v.), diamine oxidase inhibitor, aminoguanidine (65 microg/rat, i.c.v.) and agmatinase inhibitor, arcaine (50 microg/rat, i.c.v.).
Negative_regulation (inhibitor) of diamine oxidase in brain associated with anxiety disorder, agonist and clonidine
11) Confidence 0.22 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20394743 Disease Relevance 0.54 Pain Relevance 0.49
In addition, it is also important to avoid diamine-oxidase-blocking drugs and alcohol which act as inhibitors of diamine oxidase.
Negative_regulation (inhibitors) of diamine oxidase associated with alcohol
12) Confidence 0.20 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645981 Disease Relevance 0.57 Pain Relevance 0.56
Headache can be induced by histamine in wine in patients suffering from histamine intolerance, a disease characterized by impaired histamine degradation based on reduced diamine oxidase activity or a lack of the enzyme.
Negative_regulation (reduced) of diamine oxidase associated with headache and disease
13) Confidence 0.20 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645981 Disease Relevance 0.32 Pain Relevance 0.29
Histamine intolerance, based on reduced diamine oxidase activity or a lack in the enzyme is causative for wine/food-induced chronic headache.
Negative_regulation (reduced) of diamine oxidase associated with headache disorders and headache
14) Confidence 0.20 Published 1996 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 8645981 Disease Relevance 0.75 Pain Relevance 0.77
Inhibition of monoamine oxidase and histaminase by isoniazid can cause significant drug-food interactions.
Negative_regulation (Inhibition) of histaminase associated with monoamine
15) Confidence 0.10 Published 1999 Journal Am. J. Med. Sci. Section Abstract Doc Link 10334118 Disease Relevance 0.16 Pain Relevance 0.22
Inhibition of histamine synthesis by histidine decarboxylase inhibitor, GYKI 11.121, reduces clonidine-induced contraction in this preparation, while diamine oxidase inhibition by aminoguanidine potentiates it.
Negative_regulation (inhibition) of diamine oxidase associated with clonidine
16) Confidence 0.06 Published 1978 Journal Agents Actions Section Abstract Doc Link 102132 Disease Relevance 0 Pain Relevance 0.39

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