INT81723

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Context Info
Confidence 0.32
First Reported 1999
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
blood 2
dura mater 2
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
Enkephalin 6 97.28 Very High Very High Very High
Inflammation 2 74.28 Quite High
cytokine 4 50.00 Quite Low
Migraine 2 50.00 Quite Low
Potency 1 34.80 Quite Low
Inflammatory response 1 28.48 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 74.64 Quite High
Stress 1 73.60 Quite High
Adhesions 5 50.32 Quite High
Epilepsy 2 50.00 Quite Low
Headache 2 50.00 Quite Low
Necrosis 1 45.16 Quite Low
Cancer 1 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Regulation (effect) of Gene_expression (expression) of CD11a in blood associated with opioid
1) Confidence 0.32 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.92
The progressive decrease in sICAM-1 levels during attacks and the down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks.


Regulation (regulation) of Gene_expression (expression) of LFA-1 in dura mater
2) Confidence 0.02 Published 2006 Journal Headache Section Body Doc Link 16492228 Disease Relevance 0.05 Pain Relevance 0

General Comments

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