INT81733

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Context Info
Confidence 0.50
First Reported 1999
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.27
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
arcuate nucleus 2
Plasma 1
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 1 99.98 Very High Very High Very High
Opioid 2 92.16 High High
Dynorphin 2 91.44 High High
GABAergic 3 86.88 High High
gABA 2 85.20 High High
diabetic neuropathy 47 84.96 Quite High
antagonist 2 81.36 Quite High
dexamethasone 5 75.52 Quite High
Neuropeptide 4 75.00 Quite High
agonist 1 72.88 Quite High
Disease Link Frequency Relevance Heat
Stress 28 100.00 Very High Very High Very High
Hyperinsulinism 5 100.00 Very High Very High Very High
Diabetes Mellitus 209 99.90 Very High Very High Very High
Aids-related Complex 14 99.36 Very High Very High Very High
Weight Gain 9 98.90 Very High Very High Very High
Hyperphagia 2 96.88 Very High Very High Very High
Body Weight 38 94.80 High High
Nociception 17 94.64 High High
Congenital Anomalies 16 93.60 High High
Insulin Resistance 21 92.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Insulin replacement therapy was initiated 6 weeks after the induction of diabetes for one-half of the diabetic group (1.5-2.5 IU/12 h/rat) and was continued throughout the duration of the study (up to 14 weeks).
Transcription (initiated) of Insulin associated with diabetes mellitus
1) Confidence 0.50 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12376147 Disease Relevance 0.91 Pain Relevance 0
Insulin had no significant effect upon calpain 10 mRNA levels 36.
Transcription (levels) of Insulin
2) Confidence 0.35 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2536707 Disease Relevance 0.76 Pain Relevance 0
Experiments in vivo also demonstrated that increases in GAD65 mRNA expression in the arcuate nucleus preceded decreases in the NPY mRNA expression in a fasting-refeeding paradigm and that intracerebroventricular injection of insulin increased GAD65 mRNA expression in the arcuate nucleus in fasted rats.
Transcription (injection) of insulin in arcuate nucleus associated with hyperinsulinism and intracerebroventricular
3) Confidence 0.33 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16177033 Disease Relevance 0.10 Pain Relevance 0.73
Prodynorphin (proDyn) mRNA increased in diabetes and normalized in the pituitary after insulin but not in the Arc.
Transcription (normalized) of insulin in Arc associated with aids-related complex and diabetes mellitus
4) Confidence 0.33 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233022 Disease Relevance 1.36 Pain Relevance 0.16
Weight gain, tissue weight, glucose infusion rate and glucose and insulin levels, stress and sex hormones, and mRNA levels were analyzed by two-tailed t test.
Transcription (levels) of insulin associated with stress and weight gain
5) Confidence 0.30 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236959 Disease Relevance 0.38 Pain Relevance 0.06
Insulin levels were found to be much lower (1.6 ?
Transcription (found) of Insulin
6) Confidence 0.30 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2048984 Disease Relevance 0.59 Pain Relevance 0
Interestingly, the insulin receptor, which is
Transcription (receptor) of insulin
7) Confidence 0.27 Published 2008 Journal Experimental Diabetes Research Section Body Doc Link PMC2323445 Disease Relevance 0.78 Pain Relevance 0.21
In the third group, insulin treatment (7.0 IU/kg x 1 day for 3 wk) was initiated 1 wk after STZ injection.
Transcription (initiated) of insulin
8) Confidence 0.26 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233022 Disease Relevance 0.97 Pain Relevance 0.12
Plasma insulin levels were analyzed with a rat insulin radioimmunoassay kit (Linco Research Inc, St.
Spec (analyzed) Transcription (kit) of insulin in Plasma
9) Confidence 0.04 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693588 Disease Relevance 0.41 Pain Relevance 0.13

General Comments

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