INT81750

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Context Info
Confidence 0.52
First Reported 1999
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 6.03
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
nerve 2
nociceptors 2
sensory neuron 1
tooth pulp 1
hearts 1
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 44 100.00 Very High Very High Very High
Nerve growth factor 108 99.92 Very High Very High Very High
Kappa opioid receptor 4 99.44 Very High Very High Very High
Hsan 10 99.28 Very High Very High Very High
substance P 4 98.88 Very High Very High Very High
agonist 7 98.56 Very High Very High Very High
Neuropeptide 13 97.72 Very High Very High Very High
pruritus 4 94.36 High High
Congenital analgesia 2 91.64 High High
adenocard 2 91.36 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 11 99.48 Very High Very High Very High
Neuropathic Pain 3 99.48 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 10 99.28 Very High Very High Very High
Diabetes Mellitus 50 98.92 Very High Very High Very High
Targeted Disruption 52 96.64 Very High Very High Very High
Hypohidrosis 1 96.44 Very High Very High Very High
Eczema 5 96.40 Very High Very High Very High
Pruritus 4 94.36 High High
Disease 138 93.60 High High
Spinal Cord Injury 32 92.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A novel point mutation affecting the tyrosine kinase domain of the TRKA gene in a family with congenital insensitivity to pain with anhidrosis.
Regulation (affecting) of TRKA gene associated with hsan
1) Confidence 0.52 Published 1999 Journal J. Invest. Dermatol. Section Title Doc Link 10233776 Disease Relevance 0.34 Pain Relevance 0.23
With regard to Necdin expression, we examined more closely the TrkA, TrkB and TrkC sensory neuron subpopulations.
Spec (examined) Regulation (subpopulations) of TrkA in sensory neuron
2) Confidence 0.41 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.08 Pain Relevance 0
The present study suggests that the development of myelinated nociceptors is dependent on trkA and trkC but not on trkB.
Neg (not) Regulation (dependent) of trkA in nociceptors associated with nociceptor
3) Confidence 0.37 Published 2004 Journal Acta Histochem. Section Abstract Doc Link 15530548 Disease Relevance 0.53 Pain Relevance 0.21
The other population down-regulates TrkA, expresses the Ret tyrosine kinase receptor and requires GDNF for its survival [8].
Regulation (regulates) of TrkA
4) Confidence 0.37 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.24 Pain Relevance 0.67
A few years ago, point mutations affecting both coding and noncoding regions of the neurotrophic tyrosine receptor kinase type 1 (NTRK1)/nerve growth factor receptor gene have been detected in CIPA patients, demonstrating the implication of the nerve growth factor/NTRK1 pathway in the pathogenesis of the disease.
Regulation (affecting) of NTRK1 in nerve associated with nerve growth factor, disease and hsan
5) Confidence 0.36 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11719521 Disease Relevance 0.89 Pain Relevance 0.74
Interestingly, two putative target genes that are repressed by Runx1, trkA and CGRP, were unaffected in the delta446 mice [53].
Neg (unaffected) Regulation (unaffected) of trkA
6) Confidence 0.36 Published 2008 Journal Neural Develop Section Body Doc Link PMC2531103 Disease Relevance 0.65 Pain Relevance 0.15
[Effect of TRK-820, a selective kappa opioid receptor agonist, on scratching behavior in an animal model of atopic dermatitis].
Regulation ([Effect) of TRK-820 associated with agonist, kappa opioid receptor and eczema
7) Confidence 0.29 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Title Doc Link 18516986 Disease Relevance 0.64 Pain Relevance 0.59
trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice.
Regulation (modulation) of trkA in tooth pulp associated with targeted disruption and nociceptor
8) Confidence 0.24 Published 2001 Journal Neuroscience Section Title Doc Link 11516838 Disease Relevance 0.40 Pain Relevance 0.45
These effects may be related to the known redox regulation of TrkA.
Regulation (regulation) of TrkA
9) Confidence 0.22 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.32 Pain Relevance 0.27
Thus Grik1/GluR5 expression seems to coincide with the appearance of the population of nociceptors that down-regulate TrkA and express c-Ret and bind isolectin B4 [8].
Regulation (regulate) of TrkA in nociceptors associated with nociceptor
10) Confidence 0.16 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.35
Therefore, NGF-TRKA signalling might be a potential therapeutic target for sensory neuropathy in diabetic hearts [201, 202].
Spec (might) Regulation (target) of NGF-TRKA in hearts associated with diabetes mellitus and neuropathic pain
11) Confidence 0.15 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 1.10 Pain Relevance 0.04
This suggests that the lack of response to NGF is due to down-regulation of TrkA.
Regulation (regulation) of TrkA associated with nerve growth factor
12) Confidence 0.09 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0.23 Pain Relevance 0.41
Our results also indicate that overall, patients who underwent THR, TKR, APM, and ACL reconstruction surgery showed improvements in the health domains assessed by the SF-36 subscales.
Regulation (underwent) of TKR
13) Confidence 0.04 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2527304 Disease Relevance 0.26 Pain Relevance 0.13
This would affect the kinematics of the TKR.
Regulation (affect) of TKR
14) Confidence 0.02 Published 2010 Journal Acta Orthopaedica Section Abstract Doc Link PMC2917571 Disease Relevance 0 Pain Relevance 0
Additionally the down-regulation of the NGF receptor, Ntrk1 (TrkA) argues against the use of nerve growth factor (NGF) as a potential therapeutic agent.
Regulation (regulation) of TrkA in nerve associated with nerve growth factor
15) Confidence 0.02 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.35 Pain Relevance 0.13

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